{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:56:43Z","timestamp":1790557003463,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100019065","name":"Tianjin Municipal Science and Technology Program","doi-asserted-by":"publisher","award":["25ZXWZSY00080"],"award-info":[{"award-number":["25ZXWZSY00080"]}],"id":[{"id":"10.13039\/501100019065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sarcopenia, driven by inflammation and lipid dysregulation, lacks inexpensive screening tools. The white blood cell to HDL\u2010C ratio (WHR) integrates these pathways, but its utility for sarcopenia screening remains unvalidated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study evaluated the WHR\u2010sarcopenia association in dual cohorts, validated it using machine learning, and explored potential effect modification of hepatitis B virus (HBV) status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed 10\u2009131 NHANES (2011\u20132018) and 7872 KNHANES (2010\u20132011) adults. Sarcopenia was defined via DXA using FNIH\/AWGS criteria. Weighted logistic regression, restricted cubic splines, and machine learning (LASSO, XGBoost) were applied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Higher ln(WHR) was independently associated with sarcopenia in NHANES (adjusted OR\u2009=\u20092.50; 95% CI: 2.01\u20133.10) and consistently validated in KNHANES (OR\u2009=\u20091.85; 95% CI: 1.49\u20132.29). WHR ranked among the top predictive features across machine learning models. Exploratory stratified analysis suggests that the association between ln(WHR) and sarcopenia appears to be stronger in the HBV\u2010exposed subgroup. However, although the formal interaction test was not significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.270), these findings are hypothesis\u2010generating results.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>WHR, a cost\u2010free routine metric, is robustly linked to sarcopenia. Integrating it into geriatric assessments could facilitate early high\u2010risk identification for timely interventions, while exploratory findings suggesting a possible modifying role of HBV history require prospective validation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ggi.70858","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:50:31Z","timestamp":1790556631000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["White Blood Cell to\n                    <scp>HDL<\/scp>\n                    \u2010C Ratio and Sarcopenia: A Dual\u2010Cohort Analysis Including Exploratory Insights on Hepatitis B History"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4248-7737","authenticated-orcid":false,"given":"Wenshuo","family":"Cheng","sequence":"first","affiliation":[{"name":"The Third Central Clinical College of Tianjin Medical University, Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Institute of Hepatobiliary Disease, Tianjin University Central Hospital (Tianjin Third Central Hospital)  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3678-4225","authenticated-orcid":false,"given":"Huiling","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Tianjin University Central Hospital (Tianjin Third Central Hospital), Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Institute of Hepatobiliary Disease  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,27]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afq034"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2019.12.012"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.5582\/bst.2023.01246"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12051293"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00366.2001"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/rr67"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.70995"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001575"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.2196\/64456"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2025.2553786"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v15.i5.649"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyt228"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.13867"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu18091333"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889\u2010026\u201027510\u20101"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2016.03.028"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.2147\/dmso.S446894"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1317049110"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1264205"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840050206"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aohep.2024.101585"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2025.1527304"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1121778"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.122268"}],"container-title":["Geriatrics &amp; 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