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The superior spermatic nerve runs from the superior mesenteric ganglion alongside the testicular artery, whereas the inferior spermatic nerve originates in inferior mesenteric ganglion, accompanies the vas deferens and penetrates the inferior pole of the testis. The aim of this work was to evaluate androgen release after the addition of noradrenaline or adrenoreceptor antagonists (propranolol or phentolamine) to the ganglionic compartment. An ex vivo system used in a previous work was incubated in two separate containers, one for the testis and the other for the ganglion. Both organs remain interconnected (as in vivo) by the respective spermatic nerve. When noradrenaline was added to the inferior mesenteric ganglion, testosterone release in the gonad container underwent a progressive and significant increment. Propranolol diminishes and phentolamine increases the androgen release. When using the superior mesenteric ganglion, no changes were observed. These results indicate that the ganglionic stimulation of the autonomic system clearly participates in testosterone release from the testis. This effect depends on the ganglion involved. These results make it evident that not only the classical and well\u2010known hypothalamus\u2013hypophysial axis, but also the peripheral nervous system, via the autonomic ganglia, are directly involved in the endocrine control of the testis.<\/jats:p>","DOI":"10.1111\/j.1365-2605.2008.00927.x","type":"journal-article","created":{"date-parts":[[2009,7,3]],"date-time":"2009-07-03T19:50:38Z","timestamp":1246650638000},"page":"391-398","source":"Crossref","is-referenced-by-count":11,"title":["Administration of noradrenaline in the autonomic ganglia modifies the testosterone release from the testis using an ex vivo system"],"prefix":"10.1111","volume":"32","author":[{"given":"Zulema Y.","family":"Sosa","sequence":"first","affiliation":[]},{"given":"Miguel N.","family":"Palmada","sequence":"additional","affiliation":[]},{"given":"Mabel R.","family":"F\u00f3scolo","sequence":"additional","affiliation":[]},{"given":"Francisco","family":"Capani","sequence":"additional","affiliation":[]},{"given":"Alberto","family":"Conill","sequence":"additional","affiliation":[]},{"given":"Juan Carlos","family":"Cavicchia","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2009,7,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.10232"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-110-4-1124"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod33.4.815"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0031-6997(25)06932-7","article-title":"Autonomic nervous control of reproduction: circulatory and other factors","volume":"24","author":"Bell C.","year":"1972","journal-title":"Pharmacological Review"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0320253"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.6.3.1346768"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0272.1990.tb01974.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000126359"},{"key":"e_1_2_6_10_1","first-page":"205","article-title":"The sympathetic superior cervical ganglia as little neuroendocrine brains","volume":"33","author":"Cardinali D. 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