{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T06:37:54Z","timestamp":1773383874683,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"1-2","license":[{"start":{"date-parts":[[2007,2,12]],"date-time":"2007-02-12T00:00:00Z","timestamp":1171238400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:p><jats:bold>Objectives:\u2002<\/jats:bold> The European Mania in Bipolar Longitudinal Evaluation of Medication (EMBLEM) is a large\u2010scale prospective observational multicentre study to evaluate the longitudinal course of bipolar disorder and its associations with pharmacological treatment following an acute manic or mixed episode. We present an overview of the study design and patient characteristics at baseline while focusing on factors influencing work performance in the year prior to enrolment.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> A total of 530 investigators across 14 European countries enrolled 3,681 patients with acute mania between December 2002 and June 2004. Longitudinal observations are ongoing until July 2006. Socio\u2010demographic variables, psychiatric history, clinical status and information on pharmacological treatment for bipolar disorder were recorded. Items from the SLICE of LIFE were applied, including a measure of work impairment during the previous year. The distribution of the baseline characteristics was analysed with descriptive statistics. Eighteen variables were investigated as hypothesized risk factors for work impairment applying logistic regression models.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> In the previous year, 28 and 68% of patients were classified as having \u2018low\u2019 and \u2018high\u2019 work impairment, respectively. Clinical Global Impression \u2013 Bipolar Disorder (CGI\u2010BP) overall, CGI\u2010BP depression at baseline, rapid cycling during the previous 12\u2003months, age between 35 and 64\u2003years, substance abuse other than alcohol and cannabis and living without a partner or as dependent household member were significantly associated with work impairment during the previous year.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> EMBLEM is to our knowledge the largest prospective observational study assessing patients during and after an acute episode of mania. 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