{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T14:25:10Z","timestamp":1775917510181,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,8,3]],"date-time":"2011-08-03T00:00:00Z","timestamp":1312329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Primary lens luxation (PLL) is a well\u2010recognized, painful and potentially blinding inherited ocular condition in dogs. We screened PLL\u2010affected dogs of 30 different breeds, to identify those which carried a previously described c.1473+1 G&gt;A mutation in <jats:italic>ADAMTS17<\/jats:italic> that is associated with PLL in Miniature Bull terriers, Lancashire Heelers, and Jack Russell terriers. This <jats:italic>ADAMTS17<\/jats:italic> mutation was identified in PLL\u2010affected dogs from 14 additional breeds. PLL\u2010affected dogs from some breeds (most notably the Shar pei and the Brittany spaniel) did not carry the G1473+1A <jats:italic>ADAMTS17<\/jats:italic> mutation, indicating they must suffer from a genetically distinct form of the condition. We also estimated the frequency of this <jats:italic>ADAMTS17<\/jats:italic> mutation in some of the breeds. Our findings indicate the mutation segregates in a large number of different breeds of dog, many of which are terriers or breeds with terrier co\u2010ancestry, but some of which have more diverse origins. Our results also indicate that the mutation is present at high frequency within most of the breeds in which it segregates. In the miniature bull terrier breed estimates of mutation frequency ranged from 0.27 to 0.39, corresponding to 7.3\u201315.2% PLL\u2010affected dogs in this breed. We also identified an increased risk of PLL associated with heterozygosity at <jats:italic>ADAMTS17<\/jats:italic>, suggesting that carriers carry a low risk of developing PLL.<\/jats:p>","DOI":"10.1111\/j.1463-5224.2011.00892.x","type":"journal-article","created":{"date-parts":[[2011,8,3]],"date-time":"2011-08-03T13:00:44Z","timestamp":1312376444000},"page":"378-384","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["<i>ADAMTS17<\/i> mutation associated with primary lens luxation is widespread among breeds"],"prefix":"10.1111","volume":"14","author":[{"given":"David","family":"Gould","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"Pettitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryan","family":"McLaughlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nigel","family":"Holmes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Forman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saija","family":"Ahonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannes","family":"Lohi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"O\u2019Leary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Sargan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cathryn","family":"Mellersh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,8,3]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"1","article-title":"Some medical and surgical conditions in the dog and cat","volume":"12","author":"Gray H","year":"1932","journal-title":"Veterinary Record"},{"key":"e_1_2_6_3_2","first-page":"859","volume-title":"Veterinary Ophthalmology","author":"Davidson MG","year":"2007"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1980.tb05958.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.112.11.238"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.104.18.409"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-5142"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(90)50061-3"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.6772807"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08837"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2006.05.013"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2006.07.007"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/jhered\/esm029"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2009.09.011"}],"container-title":["Veterinary Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1463-5224.2011.00892.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1463-5224.2011.00892.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T23:51:23Z","timestamp":1698709883000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1463-5224.2011.00892.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8,3]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["10.1111\/j.1463-5224.2011.00892.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1463-5224.2011.00892.x","archive":["Portico"],"relation":{},"ISSN":["1463-5216","1463-5224"],"issn-type":[{"value":"1463-5216","type":"print"},{"value":"1463-5224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8,3]]},"assertion":[{"value":"2011-08-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}