{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:17:04Z","timestamp":1765545424508},"reference-count":8,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,12,17]],"date-time":"2006-12-17T00:00:00Z","timestamp":1166313600000},"content-version":"vor","delay-in-days":4855,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[1993,9]]},"abstract":"<jats:p>The Alzheimer amyloid precursor protein (APP) is a phosphoprotein, and the phosphorylation state of APP at Ser<jats:sup>655<\/jats:sup> can be regulated by protein kinase C, calcium\/calmodulin\u2010dependent protein kinase II, and okadaic acid\u2010sensitive protein phosphatases. Other enzymes may also play a role at Ser<jats:sup>655<\/jats:sup> of APP and, perhaps, at other residues.<\/jats:p><jats:p>Signal transduction via protein phosphorylation regulates APP metabolism. In particular, APP processing via the nonamyloidogenic secretory cleavage pathway is increased following the activation of protein kinase C or the inactivation of okadaic acid\u2010sensitive protein phosphatases.<\/jats:p><jats:p>The mechanism(s) by which protein phosphorylation regulates APP secretory cleavage include (among others): substrate activation, substrate redistribution, protease activation and\/or protease redistribution. Current experimental evidence will be discussed, addressing the relative importance of each of these possibilities and the implications for these events in the modulation of \u03b2\/A4\u2010amyloidogenesis.<\/jats:p>","DOI":"10.1111\/j.1749-6632.1993.tb23038.x","type":"journal-article","created":{"date-parts":[[2006,12,17]],"date-time":"2006-12-17T18:46:52Z","timestamp":1166381212000},"page":"117-121","source":"Crossref","is-referenced-by-count":29,"title":["Protein Phosphorylation Regulates Relative Utilization of Processing Pathways for Alzheimer \u03b2\/A4 Amyloid Precursor Protein<sup>a<\/sup>"],"prefix":"10.1111","volume":"695","author":[{"given":"SAMUEL E.","family":"GANDY","sequence":"first","affiliation":[]},{"given":"GREGG L.","family":"CAPORASO","sequence":"additional","affiliation":[]},{"given":"JOSEPH D.","family":"BUXBAUM","sequence":"additional","affiliation":[]},{"given":"ODETE DA CRUZ E","family":"SILVA","sequence":"additional","affiliation":[]},{"given":"KERSTIN","family":"IVERFELDT","sequence":"additional","affiliation":[]},{"given":"CHRISTER","family":"NORDSTEDT","sequence":"additional","affiliation":[]},{"given":"TOSHI","family":"SUZUKI","sequence":"additional","affiliation":[]},{"given":"ANDREW J.","family":"CZERNIK","sequence":"additional","affiliation":[]},{"given":"ANGUS C.","family":"NAIRN","sequence":"additional","affiliation":[]},{"given":"PAUL","family":"GREENGARD","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2006,12,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.16.6218"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(92)90264-3"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"4492","DOI":"10.1016\/S0021-9258(19)39590-0","article-title":"The Alzheimer amyloid precursor protein: Identification of a stable intermediate in the biosynthetic\/degradative pathway","volume":"265","author":"Oltersdorf T. 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