{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T11:30:16Z","timestamp":1780399816369,"version":"3.54.1"},"reference-count":36,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2016,1,25]],"date-time":"2016-01-25T00:00:00Z","timestamp":1453680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Beiersdorf AG"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>More than 50% of adults report to suffer from sensitive skin. This common condition is characterized by subjective sensations such as prickling, burning, skin tightness or pruritus, and is often accompanied by objective symptoms like inflammation and erythema.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study was to develop an active ingredient concept for the treatment of sensitive skin. We tested compounds regarding their potential to (i) decrease the release of proinflammatory mediators, which among others induce erythema and (ii) counteract the hyperresponsiveness of nerve fibres and, thus, exert effects on cutaneous neurosensory dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>4\u2010t\u2010butylcyclohexanol, licochalcone A and acetyl dipeptide\u20101 cetyl ester were analysed <jats:italic>in\u00a0vitro<\/jats:italic> regarding their potential to (i) decrease the release of <jats:styled-content style=\"fixed-case\">PGE<\/jats:styled-content><jats:sub>2<\/jats:sub> and activation of <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u03baB and to (ii) inhibit TRPV1 activation or the release of neuronal CGRP. To assess subjective and objective symptoms of skin sensitivity <jats:italic>in\u00a0vivo<\/jats:italic>, two controlled, single\u2010blind, randomized studies were conducted with 4\u2010t\u2010butylcyclohexanol and the combination with licochalcone A.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>In vitro<\/jats:italic>, 4\u2010t\u2010butylcyclohexanol significantly reduced <jats:styled-content style=\"fixed-case\">TRPV<\/jats:styled-content>1 activation, while acetyl dipeptide\u20101 cetyl ester had no effect on receptor activation. Licochalcone A significantly decreased <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u03baB signalling and <jats:styled-content style=\"fixed-case\">PGE<\/jats:styled-content><jats:sub>2<\/jats:sub> secretion, at lower concentrations than acetyl dipeptide\u20101 cetyl ester. A formulation containing 4\u2010t\u2010butylcyclohexanol showed a significant immediate anti\u2010stinging\/anti\u2010burning effect <jats:italic>in\u00a0vivo<\/jats:italic>, and a cream base containing a combination of 4\u2010t\u2010butylcyclohexanol and a licochalcone A\u2010rich licorice extract reduced shaving\u2010induced erythema.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic>In vitro<\/jats:italic> and <jats:italic>in\u00a0vivo<\/jats:italic> data indicate that the combination of the <jats:styled-content style=\"fixed-case\">TRPV<\/jats:styled-content>1 antagonist 4\u2010t\u2010butylcyclohexanol and the potent anti\u2010inflammatory licochalcone A provide an effective active ingredient concept for the treatment of sensitive skin, as the topical application resulted in an immediate relief from symptoms such as erythema and stinging.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.13529","type":"journal-article","created":{"date-parts":[[2016,1,25]],"date-time":"2016-01-25T12:20:34Z","timestamp":1453724434000},"page":"9-17","source":"Crossref","is-referenced-by-count":59,"title":["Effective treatment for sensitive skin: 4\u2010t\u2010butylcyclohexanol and licochalcone A"],"prefix":"10.1111","volume":"30","author":[{"given":"M.","family":"Sulzberger","sequence":"first","affiliation":[{"name":"Research &amp; 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