{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:29:09Z","timestamp":1747186149923,"version":"3.40.5"},"reference-count":53,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T00:00:00Z","timestamp":1658361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Fish Diseases"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Nephrocalcinosis is a common disorder in farmed Atlantic salmon, but the consequences for the fish physiology are not well understood. We performed a transcriptome study in kidneys of Atlantic salmon (<jats:italic>Salmo salar<\/jats:italic>) smolts without and with severe chronic nephrocalcinosis (NC). The study revealed that numerous genes are differentially expressed in fish with NC compared with healthy salmon. The most evident changes in gene expression patterns in the NC group were a massive downregulation of metabolism and energy production, upregulation of signalling pathways important for tissue repair and function maintenance and upregulation of inflammatory responses. Overall, the extensive tissue damage and the gene regulation responses that affect salmon with severe nephrocalcinosis are highly likely to have dramatic consequences on fish survival.<\/jats:p>","DOI":"10.1111\/jfd.13687","type":"journal-article","created":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T15:55:20Z","timestamp":1658418920000},"page":"1645-1658","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Gene expression patterns in Atlantic salmon (<i>Salmo salar<\/i>) with severe nephrocalcinosis"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2796-4064","authenticated-orcid":false,"given":"Christine","family":"Klykken","sequence":"first","affiliation":[{"name":"Aqua Kompetanse AS  Flatanger Norway"},{"name":"Department of Biology, Faculty of Science and Technology Norwegian University of Science and Technology  Trondheim Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauris","family":"Boissonnot","sequence":"additional","affiliation":[{"name":"Aqua Kompetanse AS  Flatanger Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Katrine","family":"Reed","sequence":"additional","affiliation":[{"name":"Pharmaq Analytiq AS  Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Whatmore","sequence":"additional","affiliation":[{"name":"eResearch Department Queensland Univesity of Technology  Brisbane QLD Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kari","family":"Attramadal","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Food Science Faculty of Science and Technology Norwegian University of Science and Technology  Trondheim Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf Erik","family":"Olsen","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science and Technology Norwegian University of Science and Technology  Trondheim Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,21]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Akvakulturdriftsforskriften(2008).Forskrift om drift av akvakulturanlegg for\u20102008\u201006\u201017\u2010822."},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/01652176.2015.1123823"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3354\/dao03477"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.2741\/Beyenbach"},{"key":"e_1_2_10_7_1","unstructured":"Bjerknes V. Lydersen E. Golmen L. Hob\u00e6k A. andHoltet L.(1994).Nefrokalsinose hos regnbueaure i oppdrettsanlegg ved trengereid. NIVA\u2010RAPPORT. ISBN\u201082\u2010577\u20102487\u20104 22p."},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1040638718809407"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2005.04.004"},{"key":"e_1_2_10_10_1","first-page":"1","article-title":"Nephrocalcinosis","volume":"16","author":"Bruno D. W.","year":"1996","journal-title":"Aquaculture Information Series"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2020.736212"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/raq.12298"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-05594-9.00002-7"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00045.2005"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-017-3945-6"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1139\/f79-100"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2761.1979.tb00134.x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2761.1984.tb01202.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3317"},{"key":"e_1_2_10_20_1","first-page":"138","article-title":"Nephrocalcinosis and kidney stones in Rachycentron canadum","volume":"35","author":"Klosterhoff M.","year":"2015","journal-title":"Bulletin of the European Association of Fish Pathologists"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2022.738104"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-029X.125211"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfd.12013"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2017.11.041"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2010.12.024"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt656"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2021.736653"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dci.2016.03.014"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dci.2017.02.024"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1201\/b10994-12"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2007.05.011"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2613.2000.00163.x"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02872"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjaceaccp\/mkl018"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.18805\/ag.R-1549"},{"key":"e_1_2_10_37_1","first-page":"62","article-title":"The pathophysiology and systematic pathology of teleosts","volume":"3","author":"Roberts R.","year":"2012","journal-title":"Fisheries Pathology"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00157809"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxr088"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbd.2015.04.001"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2016.03.048"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20040048"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jctube.2017.02.001"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2015.76"},{"key":"e_1_2_10_45_1","first-page":"21","article-title":"Insecticidies and ionic regulation in teleosts: A review","volume":"47","author":"Singh N.","year":"2002","journal-title":"Zoologica Poloniae"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2761.1979.tb00170.x"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19010245"},{"volume-title":"Bancroft's Theory and Practice of Histological Techniques","year":"2019","author":"Suvarna K. S.","key":"e_1_2_10_48_1"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.664588"},{"key":"e_1_2_10_50_1","first-page":"779","article-title":"Otolith calcification in Atlantic salmon parr","volume":"40","author":"Talbot C.","year":"1992","journal-title":"Blood"},{"volume-title":"R: A language and environment for statistical computing","year":"2017","author":"Team, R. C","key":"e_1_2_10_51_1"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1139\/f04-050"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1080\/15592294.2018.1554520"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2018.03.046"}],"container-title":["Journal of Fish Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jfd.13687","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jfd.13687","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jfd.13687","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T11:40:23Z","timestamp":1692704423000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jfd.13687"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,21]]},"references-count":53,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1111\/jfd.13687"],"URL":"https:\/\/doi.org\/10.1111\/jfd.13687","archive":["Portico"],"relation":{},"ISSN":["0140-7775","1365-2761"],"issn-type":[{"type":"print","value":"0140-7775"},{"type":"electronic","value":"1365-2761"}],"subject":[],"published":{"date-parts":[[2022,7,21]]},"assertion":[{"value":"2022-04-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}