{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T08:49:22Z","timestamp":1791449362755,"version":"4.3.3"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004694","name":"Kaohsiung Medical University","doi-asserted-by":"publisher","award":["NSTC 113\u20102314\u2010B\u2010110\u2010005\u2010MY3"],"award-info":[{"award-number":["NSTC 113\u20102314\u2010B\u2010110\u2010005\u2010MY3"]}],"id":[{"id":"10.13039\/501100004694","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004694","name":"Kaohsiung Medical University","doi-asserted-by":"publisher","award":["NSYSU\u2010KMU\u2010114\u2010P32"],"award-info":[{"award-number":["NSYSU\u2010KMU\u2010114\u2010P32"]}],"id":[{"id":"10.13039\/501100004694","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004694","name":"Kaohsiung Medical University","doi-asserted-by":"publisher","award":["NSTC 113\u20102314\u2010B\u2010037\u2010061"],"award-info":[{"award-number":["NSTC 113\u20102314\u2010B\u2010037\u2010061"]}],"id":[{"id":"10.13039\/501100004694","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004694","name":"Kaohsiung Medical University","doi-asserted-by":"publisher","award":["NSTC 114\u20102314\u2010B\u2010037\u2010102\u2010MY2"],"award-info":[{"award-number":["NSTC 114\u20102314\u2010B\u2010037\u2010102\u2010MY2"]}],"id":[{"id":"10.13039\/501100004694","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011645","name":"Kaohsiung Medical University Chung-Ho Memorial Hospital","doi-asserted-by":"publisher","award":["KMUH111\u20101R03"],"award-info":[{"award-number":["KMUH111\u20101R03"]}],"id":[{"id":"10.13039\/501100011645","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011645","name":"Kaohsiung Medical University Chung-Ho Memorial Hospital","doi-asserted-by":"publisher","award":["KMUH112\u20102R08"],"award-info":[{"award-number":["KMUH112\u20102R08"]}],"id":[{"id":"10.13039\/501100011645","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["MOHW114\u2010TDU\u2010B\u2010221\u2010144007"],"award-info":[{"award-number":["MOHW114\u2010TDU\u2010B\u2010221\u2010144007"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>A residual risk of hepatocellular carcinoma (HCC) persists despite the use of nucleos(t)ide analogs (NA) in chronic hepatitis B (CHB) patients. We aimed to assess the utility of baseline serum laminin gamma 2 monomer (LG2m) by integrating PAGE\u2010B score to predict HCC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>NA\u2010treated CHB patients whose baseline serum LG2m, alpha\u2010fetoprotein (AFP) and PAGE\u2010B score were measured. We evaluated the predictive value of LG2m in subgroups stratified by cirrhosis status and PAGE\u2010B score and proposed a HCC surveillance algorithm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      HCC developed in 56 of 1016 patients over a follow\u2010up of 3651 person\u2010years (annual incidence: 1.53%). None of the low PAGE\u2010B patients developed HCC over 5\u2009years. LG2m did not significantly stratify risk in high PAGE\u2010B patients. Conversely, LG2m was significantly predictive of HCC in nonhigh PAGE\u2010B patients (5\u2010year incidence: 5.5% vs. 1.0% for high vs. low LG2m,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004). Integrating LG2m, AFP, and high PAGE\u2010B achieved a sensitivity of 98.2% for HCC detection. Among patients with a nonhigh PAGE\u2010B score, elevated LG2m was associated with a higher risk of HCC (adjusted HR, 4.40; 95% CI, 1.26\u201315.44), whereas AFP did not significantly stratify HCC risk in a separate analysis. Intermediate PAGE\u2010B patients with high LG2m should receive closer HCC surveillance (annual incidence: 1.4%) as with high PAGE\u2010B patients did (annual incidence: 1.9%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Serum LG2m level was predictive of HCC specifically among patients with intermediate PAGE\u2010B score. Integration of LG2m into a PAGE\u2010B\u2010oriented algorithm provides a biomarker\u2010driven tool for individualized surveillance, which is vital for improving early\u2010stage HCC detection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70792","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:52:30Z","timestamp":1791445950000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Clinical Utility of Adding Laminin Gamma 2 Monomer to the PAGE\u2010B Score for Hepatocellular Carcinoma Surveillance in Chronic Hepatitis B"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3367-068X","authenticated-orcid":false,"given":"Chung\u2010Feng","family":"Huang","sequence":"first","affiliation":[{"name":"Hepatobiliary Division, Department of Internal Medicine Kaohsiung Medical University Hospital; College of Medicine and Center for Liquid Biopsy and Cohort Research, Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Faculty of Internal Medicine and Hepatitis Research Center, School of Medicine, College of Medicine Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Ph.D. Program in Translational Medicine, College of Medicine Kaohsiung Medical University, Kaohsiung, and Academia Sinica  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9189-6604","authenticated-orcid":false,"given":"Po\u2010Cheng","family":"Liang","sequence":"additional","affiliation":[{"name":"Hepatobiliary Division, Department of Internal Medicine Kaohsiung Medical University Hospital; College of Medicine and Center for Liquid Biopsy and Cohort Research, Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao\u2010Kuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Hepatobiliary Division, Department of Internal Medicine Kaohsiung Medical University Hospital; College of Medicine and Center for Liquid Biopsy and Cohort Research, Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Department of Internal Medicine Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Stec","sequence":"additional","affiliation":[{"name":"Abbott Laboratories Discovery Research  Abbott Park Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Anderson","sequence":"additional","affiliation":[{"name":"Abbott Laboratories Discovery Research  Abbott Park Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin","family":"Cloherty","sequence":"additional","affiliation":[{"name":"Abbott Laboratories Discovery Research  Abbott Park Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5044-6727","authenticated-orcid":false,"given":"Pei\u2010Chien","family":"Tsai","sequence":"additional","affiliation":[{"name":"Hepatobiliary Division, Department of Internal Medicine Kaohsiung Medical University Hospital; College of Medicine and Center for Liquid Biopsy and Cohort Research, Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu\u2010Chun","family":"Lin","sequence":"additional","affiliation":[{"name":"Hepatobiliary Division, Department of Internal Medicine Kaohsiung Medical University Hospital; College of Medicine and Center for Liquid Biopsy and Cohort Research, Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Min","family":"Ko","sequence":"additional","affiliation":[{"name":"Hepatobiliary Division, Department of Internal Medicine Kaohsiung Medical University Hospital; College of Medicine and Center for Liquid Biopsy and Cohort Research, Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5251-1318","authenticated-orcid":false,"given":"Yi\u2010Shan","family":"Tsai","sequence":"additional","affiliation":[{"name":"Hepatobiliary Division, Department of Internal Medicine Kaohsiung Medical University Hospital; College of Medicine and Center for Liquid Biopsy and Cohort Research, Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9350-2699","authenticated-orcid":false,"given":"Kuan\u2010Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Hepatobiliary Division, Department of Internal Medicine Kaohsiung Medical University Hospital; College of Medicine and Center for Liquid Biopsy and Cohort Research, Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching\u2010Chih","family":"Lin","sequence":"additional","affiliation":[{"name":"Hepatobiliary Division, Department of Internal Medicine Kaohsiung Medical University Hospital; College of Medicine and Center for Liquid Biopsy and Cohort Research, Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2961-130X","authenticated-orcid":false,"given":"Tyng\u2010Yuan","family":"Jang","sequence":"additional","affiliation":[{"name":"Hepatobiliary Division, Department of Internal Medicine Kaohsiung Medical University Hospital; College of Medicine and Center for Liquid Biopsy and Cohort Research, Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Faculty of Internal Medicine and Hepatitis Research Center, School of Medicine, College of Medicine Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4720-599X","authenticated-orcid":false,"given":"Chih\u2010Wen","family":"Wang","sequence":"additional","affiliation":[{"name":"Hepatobiliary Division, Department of Internal Medicine Kaohsiung Medical University Hospital; College of Medicine and Center for Liquid Biopsy and Cohort Research, Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Faculty of Internal Medicine and Hepatitis Research Center, School of Medicine, College of Medicine Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1266-7796","authenticated-orcid":false,"given":"Yu\u2010Ju","family":"Wei","sequence":"additional","affiliation":[{"name":"Hepatobiliary Division, Department of Internal Medicine Kaohsiung Medical University Hospital; College of Medicine and Center for Liquid Biopsy and Cohort Research, Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Faculty of Internal Medicine and Hepatitis Research Center, School of Medicine, College of Medicine Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Hung","family":"Lin","sequence":"additional","affiliation":[{"name":"Hepatobiliary Division, Department of Internal Medicine Kaohsiung Medical University Hospital; College of Medicine and Center for Liquid Biopsy and Cohort Research, Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Department of Internal Medicine Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Yen","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Hepatobiliary Division, Department of Internal Medicine Kaohsiung Medical University Hospital; College of Medicine and Center for Liquid Biopsy and Cohort Research, Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Department of Internal Medicine Kaohsiung Municipal Gangshan Hospital, Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8489-7147","authenticated-orcid":false,"given":"Zu\u2010Yau","family":"Lin","sequence":"additional","affiliation":[{"name":"Hepatobiliary Division, Department of Internal Medicine Kaohsiung Medical University Hospital; College of Medicine and Center for Liquid Biopsy and Cohort Research, Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Faculty of Internal Medicine and Hepatitis Research Center, School of Medicine, College of Medicine Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3728-7618","authenticated-orcid":false,"given":"Ming\u2010Lun","family":"Yeh","sequence":"additional","affiliation":[{"name":"Hepatobiliary Division, Department of Internal Medicine Kaohsiung Medical University Hospital; College of Medicine and Center for Liquid Biopsy and Cohort Research, Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Faculty of Internal Medicine and Hepatitis Research Center, School of Medicine, College of Medicine Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"School of Medicine, College of Medicine and Center of Excellence for Metabolic Associated Fatty Liver Disease National Sun Yat\u2010sen University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2752-7051","authenticated-orcid":false,"given":"Jee\u2010Fu","family":"Huang","sequence":"additional","affiliation":[{"name":"Hepatobiliary Division, Department of Internal Medicine Kaohsiung Medical University Hospital; College of Medicine and Center for Liquid Biopsy and Cohort Research, Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Faculty of Internal Medicine and Hepatitis Research Center, School of Medicine, College of Medicine Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia\u2010Yen","family":"Dai","sequence":"additional","affiliation":[{"name":"Hepatobiliary Division, Department of Internal Medicine Kaohsiung Medical University Hospital; College of Medicine and Center for Liquid Biopsy and Cohort Research, Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Faculty of Internal Medicine and Hepatitis Research Center, School of Medicine, College of Medicine Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2376-421X","authenticated-orcid":false,"given":"Wan\u2010Long","family":"Chuang","sequence":"additional","affiliation":[{"name":"Hepatobiliary Division, Department of Internal Medicine Kaohsiung Medical University Hospital; College of Medicine and Center for Liquid Biopsy and Cohort Research, Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Faculty of Internal Medicine and Hepatitis Research Center, School of Medicine, College of Medicine Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8145-1900","authenticated-orcid":false,"given":"Ming\u2010Lung","family":"Yu","sequence":"additional","affiliation":[{"name":"Hepatobiliary Division, Department of Internal Medicine Kaohsiung Medical University Hospital; College of Medicine and Center for Liquid Biopsy and Cohort Research, Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Faculty of Internal Medicine and Hepatitis Research Center, School of Medicine, College of Medicine Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,8]]},"reference":[{"issue":"17","key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1001\/jama.2018.3795","article-title":"Chronic Hepatitis B Infection: A Review","volume":"319","author":"Tang L. S. Y.","year":"2018","journal-title":"JAMA"},{"issue":"12","key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1056\/NEJMra1001683","article-title":"Hepatocellular Carcinoma","volume":"365","author":"El\u2010Serag H. B.","year":"2011","journal-title":"New England Journal of Medicine"},{"issue":"2","key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.jhep.2025.03.018","article-title":"EASL Clinical Practice Guidelines on the Management of Hepatitis B Virus Infection","volume":"83","year":"2025","journal-title":"Journal of Hepatology"},{"issue":"5","key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1097\/HEP.0000000000000459","article-title":"Antiviral Therapy Substantially Reduces HCC Risk in Patients With Chronic Hepatitis B Infection in the Indeterminate Phase","volume":"78","author":"Huang D. Q.","year":"2023","journal-title":"Hepatology (Baltimore, md)"},{"issue":"4","key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S2468-1253(24)00431-X","article-title":"Early Antiviral Treatment With Tenofovir Alafenamide to Prevent Serious Clinical Adverse Events in Adults With Chronic Hepatitis B and Moderate or High Viraemia (ATTENTION): Interim Results From a Randomised Controlled Trial","volume":"10","author":"Lim Y. S.","year":"2025","journal-title":"Lancet Gastroenterology & Hepatology"},{"issue":"4","key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.jhep.2015.01.002","article-title":"Risk of Hepatocellular Carcinoma in Chronic Hepatitis B: Assessment and Modification With Current Antiviral Therapy","volume":"62","author":"Papatheodoridis G. V.","year":"2015","journal-title":"Journal of Hepatology"},{"issue":"8","key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1111\/apt.13774","article-title":"Reduction of Chronic Hepatitis B\u2010Related Hepatocellular Carcinoma With Anti\u2010Viral Therapy, Including Low Risk Patients","volume":"44","author":"Lin D.","year":"2016","journal-title":"Alimentary Pharmacology & Therapeutics"},{"issue":"1","key":"e_1_2_9_9_1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/liv.15085","article-title":"On\u2010Treatment Gamma\u2010Glutamyl Transferase Predicts the Development of Hepatocellular Carcinoma in Chronic Hepatitis B Patients","volume":"42","author":"Huang C. F.","year":"2022","journal-title":"Liver International: Official Journal of the International Association for the Study of the Liver"},{"issue":"9","key":"e_1_2_9_10_1","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.14309\/ajg.0000000000001865","article-title":"Comparative Performance of 14 HCC Prediction Models in CHB: A Dynamic Validation at Serial On\u2010Treatment Timepoints","volume":"117","author":"Wu S.","year":"2022","journal-title":"American Journal of Gastroenterology"},{"key":"e_1_2_9_11_1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.reth.2021.03.002","article-title":"Liver Cancer Stem Cells: Recent Progress in Basic and Clinical Research","volume":"17","author":"Yamashita T.","year":"2021","journal-title":"Regenerative Therapy"},{"issue":"2","key":"e_1_2_9_12_1","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1002\/hep.31758","article-title":"Serum Laminin \u03b32 Monomer as a Diagnostic and Predictive Biomarker for Hepatocellular Carcinoma","volume":"74","author":"Yamashita T.","year":"2021","journal-title":"Hepatology (Baltimore, md)"},{"issue":"1","key":"e_1_2_9_13_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-77068-4","article-title":"Serum Laminin \u03b32 Monomer as a Predictive Biomarker for Hepatocellular Carcinoma in Patients With Chronic Hepatitis B Virus Infection: A Retrospective Cohort Study","volume":"14","author":"Nio K.","year":"2024","journal-title":"Scientific Reports"},{"issue":"1","key":"e_1_2_9_14_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-16059-5","article-title":"Combining Serologic Biomarkers With the PAGE B Score Improves Risk Stratification for Hepatocellular Carcinoma Development Among Chronic Hepatitis B Patients","volume":"15","author":"Stec M.","year":"2025","journal-title":"Scientific Reports"},{"issue":"9","key":"e_1_2_9_15_1","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1111\/jgh.70021","article-title":"Steatotic Liver Disease\u2010Related Polygenetic Risk Score Prediction of Hepatocellular Carcinoma in Nucleotide\/Nucleoside Analog\u2010Treated Chronic Hepatitis B","volume":"40","author":"Jang T. Y.","year":"2025","journal-title":"Journal of Gastroenterology and Hepatology"},{"key":"e_1_2_9_16_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jfma.2018.11.008","article-title":"Taiwan Consensus Statement on the Management of Chronic Hepatitis B","volume":"118","author":"Chien R. N.","year":"2019","journal-title":"Journal of the Formosan Medical Association = Taiwan Yi Zhi"},{"issue":"8","key":"e_1_2_9_17_1","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1080\/00365540902875073","article-title":"Performance Characteristics of Two Real\u2010Time PCR Assays for Quantification of Hepatitis B Virus DNA","volume":"41","author":"Lin Y. Y.","year":"2009","journal-title":"Scandinavian Journal of Infectious Diseases"},{"issue":"2","key":"e_1_2_9_18_1","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1053\/j.gastro.2004.11.018","article-title":"Prospective Comparison of Transient Elastography, Fibrotest, APRI, and Liver Biopsy for the Assessment of Fibrosis in Chronic Hepatitis C","volume":"128","author":"Castera L.","year":"2005","journal-title":"Gastroenterology"},{"issue":"4","key":"e_1_2_9_19_1","doi-asserted-by":"crossref","first-page":"883","DOI":"10.3350\/cmh.2024.0414","article-title":"Dynamic Change of Metabolic Dysfunction\u2010Associated Steatotic Liver Disease in Chronic Hepatitis C Patients After Viral Eradication: A Nationwide Registry Study in Taiwan","volume":"30","author":"Huang C. F.","year":"2024","journal-title":"Clinical and Molecular Hepatology"},{"issue":"4","key":"e_1_2_9_20_1","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s12072-017-9799-9","article-title":"Asia\u2010Pacific Clinical Practice Guidelines on the Management of Hepatocellular Carcinoma: A 2017 Update","volume":"11","author":"Omata M.","year":"2017","journal-title":"Hepatology International"},{"issue":"6","key":"e_1_2_9_21_1","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1097\/HEP.0000000000000466","article-title":"AASLD Practice Guidance on Prevention, Diagnosis, and Treatment of Hepatocellular Carcinoma","volume":"78","author":"Singal A. G.","year":"2023","journal-title":"Hepatology (Baltimore, md)"},{"issue":"2","key":"e_1_2_9_22_1","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.jhep.2024.08.028","article-title":"EASL Clinical Practice Guidelines on the Management of Hepatocellular Carcinoma","volume":"82","year":"2025","journal-title":"Journal of Hepatology"},{"issue":"5","key":"e_1_2_9_23_1","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.jhep.2019.12.005","article-title":"Reassessing the Accuracy of PAGE\u2010B\u2010Related Scores to Predict Hepatocellular Carcinoma Development in Patients With Chronic Hepatitis B","volume":"72","author":"Yip T. C.","year":"2020","journal-title":"Journal of Hepatology"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.70792","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jgh.70792","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.70792","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:52:34Z","timestamp":1791445954000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.70792"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,8]]},"references-count":22,"alternative-id":["10.1111\/jgh.70792"],"URL":"https:\/\/doi.org\/10.1111\/jgh.70792","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,8]]},"assertion":[{"value":"2026-08-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"jgh.70792"}}