{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T15:33:17Z","timestamp":1781710397471,"version":"3.54.5"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,3,4]],"date-time":"2019-03-04T00:00:00Z","timestamp":1551657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Sao Paulo"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The combination of oral supplementation and topical formulations to the improvement of skin conditions has been proposed as an innovative approach to obtain effective treatments. However, studies comparing the effectiveness of each type of treatments are still in lack. This way, the objective of this work was to evaluate the clinical efficacy of a dermocosmetic formulation with di\u2010 and tripeptides, as well the effects of an oral supplementation based on hydrolyzed collagen through biophysical and skin imaging techniques.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty healthy female subjects, aged between 40 and 50\u00a0years, were enrolled, being separated in 3 groups: topical formulation, oral supplementation, and oral placebo. The stratum corneum water content, skin viscoelasticity, dermis echogenicity, and skin pores parameters were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The group with the topical formulation showed a significant increase in the stratum corneum water content and skin elasticity after 28\u2010day period and also acted in the dermis echogenicity after 90\u00a0days with the formulation with peptides. The oral supplementation acted on skin elasticity and presented a more pronounced effect on dermis echogenicity, reducing skin pores after 90\u2010day period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The obtained results with oral supplementation and topical application of hydrolyzed proteins were considered complementary in the improvement of general skin conditions, acting in different mechanisms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12893","type":"journal-article","created":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T05:26:33Z","timestamp":1551763593000},"page":"1693-1699","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Topical application and oral supplementation of peptides in the improvement of skin viscoelasticity and density"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6678-1207","authenticated-orcid":false,"given":"Patricia M. B. G.","family":"Maia Campos","sequence":"first","affiliation":[{"name":"Faculty of Pharmaceutical Sciences of Ribeir\u00e3o Preto University of S\u00e3o Paulo Ribeir\u00e3o Preto Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maisa Oliveira","family":"Melo","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences of Ribeir\u00e3o Preto University of S\u00e3o Paulo Ribeir\u00e3o Preto Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francine Celise","family":"Siqueira C\u00e9sar","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences of Ribeir\u00e3o Preto University of S\u00e3o Paulo Ribeir\u00e3o Preto Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000351376"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/ciia.2006.1.2.115"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtv.2016.03.002"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2003.16"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12174"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.18311\/jnr\/2016\/7220"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1363755"},{"key":"e_1_2_8_9_1","first-page":"291","volume-title":"Skin Aging Handbook: An Integrated Approach to Biochemistry and Product Development","author":"Cernasov D","year":"2008"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14280"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules191118268"},{"key":"e_1_2_8_12_1","first-page":"361","article-title":"Skin moisturizing effects of panthenol\u2010based formulations","volume":"62","author":"Camargo FB","year":"2011","journal-title":"J Cosmet Sci"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0846.2000.006004239.x"},{"key":"e_1_2_8_14_1","first-page":"329","volume-title":"Handbook of Non\u2010Invasive Methods and the Skin","author":"Gniadecka M","year":"1998"},{"key":"e_1_2_8_15_1","article-title":"Stability and clinical efficacy of cosmetic formulations containing different peptides","author":"Anconi GL","year":"2008","journal-title":"IFSCC Congress \u2013 Barcelona"},{"issue":"6","key":"e_1_2_8_16_1","first-page":"30","article-title":"Comprehensive Treatment of Periorbital Region with Hyaluronic Acid","volume":"8","author":"Bravo B","year":"2015","journal-title":"J Clin Aesthet Dermatol"},{"issue":"9","key":"e_1_2_8_17_1","first-page":"39","article-title":"The tricky tear trough: a review of topical cosmeceuticals for periorbital skin rejuvenation","volume":"8","author":"Pilkington SJ","year":"2015","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.2310\/6350.2005.31245"},{"key":"e_1_2_8_19_1","first-page":"1747","article-title":"Daily consumption of the collagen supplement Pure Gold Collagen\u00ae reduces visible signs of aging","volume":"9","author":"Borumand M","year":"2014","journal-title":"Clin Interv Aging"},{"key":"e_1_2_8_20_1","first-page":"1","article-title":"Evaluation of the in vivo cosmetic efficacy of the MF3 blue cell serum gel. 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