{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T03:30:14Z","timestamp":1772595014699,"version":"3.50.1"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":3016,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Spanish Ministry of Economy and Competitiveness","doi-asserted-by":"publisher","award":["IJCI-2014-19428"],"award-info":[{"award-number":["IJCI-2014-19428"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Oral administration of glucocorticoid alters serum cystatin C (sCysC) concentration in humans.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine if oral administration of prednisone alters sCysC in dogs without pre-existing renal disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Forty six dogs were included: 10 dogs diagnosed with steroid responsive meningitis arteritis (SRMA; group A), 20 dogs diagnosed of pituitary-dependent hyperadrenocorticism (PDH; group B), and 16 healthy control dogs (group C).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective observational study. SRMA diagnosed dogs were administered prednisone 4 mg\/kg\/24 h PO 7 days, reducing the dose to 2 mg\/kg\/24 h 7 days before medication withdrawal. In group A, sampling was performed at days 0, 7, 14 and a final control at day 21. Blood and urine samples were collected in the 3 groups, and in group A, sampling was performed at all time points (days 1, 7, 14, and 21).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In group A, sCysC was significantly higher at day 7 compared to the control group (0.4 \u00b1 0.04 mg\/L vs. 0.18 \u00b1 0.03 mg\/L mean \u00b1 SEM respectively P &amp;lt; 0.01); sCysC values decreased to basal at day 14 when the dose was decreased and after 1 week of withdrawal of prednisone (0.27 \u00b1 0.03 mg\/L for group A at day 14 and 0.15 \u00b1 0.02 mg\/L at day 21; P &amp;gt; 0.05). Dogs with PDH included in group B did not have significant differences in sCysC (0.22 \u00b1 0.03 mg\/L) compared to control (P &amp;gt; 0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Oral administration of prednisone unlike altered endogenous glucocorticoid production, increases sCysC in dogs in a dose-dependent fashion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.14820","type":"journal-article","created":{"date-parts":[[2017,9,18]],"date-time":"2017-09-18T10:52:06Z","timestamp":1505731926000},"page":"1765-1770","source":"Crossref","is-referenced-by-count":12,"title":["Effects of Oral Prednisone Administration on Serum Cystatin C in Dogs"],"prefix":"10.1093","volume":"31","author":[{"given":"J.","family":"Mu\u00f1oz","sequence":"first","affiliation":[{"name":"Faculty of Veterinary Sciences, University of Extremadura Animal Medicine Department, , C\u00e1ceres,","place":["Spain"]}]},{"given":"P.","family":"Soblechero","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Sciences, University of Extremadura Animal Medicine Department, , C\u00e1ceres,","place":["Spain"]}]},{"given":"F.J.","family":"Duque","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Sciences, University of Extremadura Animal Medicine Department, , C\u00e1ceres,","place":["Spain"]}]},{"given":"B.","family":"Mac\u00edas-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Assisted Reproduction Unit, Minimally Invasive Surgery Centre Jes\u00fasUs\u00f3n , C\u00e1ceres,","place":["Spain"]}]},{"given":"P.","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Sciences, University of Extremadura Animal Medicine Department, , C\u00e1ceres,","place":["Spain"]}]},{"given":"C.","family":"Zaragoza","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary 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