{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T11:44:31Z","timestamp":1776080671991,"version":"3.50.1"},"reference-count":5,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>SPINK5\u2010syndromic epidermal differentiation disorder (sEDD) (formerly known as Netherton syndrome) is a rare genodermatosis characterized by ichthyosis linearis circumflexa, atopic diathesis, and trichorrhexis invaginata. We report an 11\u2010year\u2010old girl with SPINK5\u2010sEDD who experienced marked improvement in hair density, texture, and pruritus following dupilumab. The early and sustained hair response suggests that IL\u20104\/IL\u201013 blockade may modulate the perifollicular inflammatory environment and enhance follicular function. This observation supports emerging evidence that dupilumab may confer hair benefits in SPINK5\u2010sEDD and underscores the need for systematic evaluation of this effect.<\/jats:p>","DOI":"10.1111\/pde.70194","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T10:46:21Z","timestamp":1776077181000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hair Improvement in\n                    <scp>SPINK5<\/scp>\n                    \u2010\n                    <scp>sEDD<\/scp>\n                    (Netherton Syndrome) With Dupilumab"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2413-3556","authenticated-orcid":false,"given":"Manuel Bernardo","family":"Costa","sequence":"first","affiliation":[{"name":"Servi\u00e7o de Dermatologia e Venereologia Unidade Local de Sa\u00fade S\u00e3o Jo\u00e3o  Porto Portugal"}]},{"given":"Rafael Baptista","family":"Santos","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Dermatologia e Venereologia Unidade Local de Sa\u00fade S\u00e3o Jo\u00e3o  Porto Portugal"}]},{"given":"B\u00e1rbara Vieira","family":"Granja","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Dermatologia e Venereologia Unidade Local de Sa\u00fade S\u00e3o Jo\u00e3o  Porto Portugal"},{"name":"Departamento de Medicina, Faculdade de Medicina Universidade do Porto  Porto Portugal"}]},{"given":"Maria Jo\u00e3o","family":"Cruz","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Dermatologia e Venereologia Unidade Local de Sa\u00fade S\u00e3o Jo\u00e3o  Porto Portugal"},{"name":"Departamento de Medicina, Faculdade de Medicina Universidade do Porto  Porto Portugal"}]},{"given":"Ana","family":"Pedrosa","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Dermatologia e Venereologia Unidade Local de Sa\u00fade S\u00e3o Jo\u00e3o  Porto Portugal"},{"name":"Departamento de Medicina, Faculdade de Medicina Universidade do Porto  Porto Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2467-4926","authenticated-orcid":false,"given":"Alberto","family":"Mota","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Dermatologia e Venereologia Unidade Local de Sa\u00fade S\u00e3o Jo\u00e3o  Porto Portugal"},{"name":"Departamento de Medicina, Faculdade de Medicina Universidade do Porto  Porto Portugal"},{"name":"RISE\u2010Health, Faculdade de Medicina Universidade do Porto  Porto Portugal"}]}],"member":"311","published-online":{"date-parts":[[2026,4,13]]},"reference":[{"key":"e_1_2_1_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacig.2025.100508"},{"key":"e_1_2_1_7_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2025.2576575"},{"key":"e_1_2_1_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.14197"},{"key":"e_1_2_1_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14664"},{"key":"e_1_2_1_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.70113"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.70194","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pde.70194","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.70194","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T10:46:22Z","timestamp":1776077182000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.70194"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,13]]},"references-count":5,"alternative-id":["10.1111\/pde.70194"],"URL":"https:\/\/doi.org\/10.1111\/pde.70194","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,13]]},"assertion":[{"value":"2025-12-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"pde.70194"}}