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Still, it entails numerous challenges, including balancing the dietary essential amino acids, as alternative ingredients, such as plant proteins, insect meals, single\u2010cell proteins, or animal by\u2010products, are usually deficient in some amino acids, particularly methionine (Met). Besides being required for protein synthesis and maintenance purposes, Met serves as a methyl donor. It plays an important role in the antioxidant system through its downstream metabolites, for example, glutathione and taurine. In practical diets, the requirements of animals are fulfilled from three primary sources: L\u2010Met (the natural form of Met), DL\u2010Met, and DL\u2010hydroxy\u2010Met (OH\u2010Met). Dispersed literature data are available on the efficiency of using these dietary Met sources in aquaculture finfish species. This review intends to compare the efficacy of the different dietary Met sources in finfish growth and their potential role in the antioxidant defense system.<\/jats:p>","DOI":"10.1111\/raq.70049","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T04:35:10Z","timestamp":1750221310000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparing Methionine Synthetic Sources: Supplementation of Aquafeeds, Bioefficacy, and Effects on Finfish Oxidative Status"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3072-8364","authenticated-orcid":false,"given":"In\u00eas","family":"Guerreiro","sequence":"first","affiliation":[{"name":"CIIMAR\/CIMAR LA, Interdisciplinary Centre of Marine and Environmental Research University of Porto, Terminal de Cruzeiros do Porto de Leix\u00f5es  Matosinhos Portugal"},{"name":"FCUP \u2010 Department of Biology, Faculty of Sciences University of Porto  Porto Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7662-3437","authenticated-orcid":false,"given":"Tahir","family":"Mahmood","sequence":"additional","affiliation":[{"name":"Adisseo France SAS, CERN  Malicorne France"}]},{"given":"Yves","family":"Mercier","sequence":"additional","affiliation":[{"name":"Adisseo France SAS, CERN  Malicorne France"}]},{"given":"Waldo G.","family":"Nuez\u2010Ortin","sequence":"additional","affiliation":[{"name":"Adisseo Belgium  Dendermonde Belgium"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5730-836X","authenticated-orcid":false,"given":"Aires","family":"Oliva\u2010Teles","sequence":"additional","affiliation":[{"name":"CIIMAR\/CIMAR LA, Interdisciplinary Centre of Marine and Environmental Research University of Porto, Terminal de Cruzeiros do Porto de Leix\u00f5es  Matosinhos Portugal"},{"name":"FCUP \u2010 Department of Biology, Faculty of Sciences University of Porto  Porto Portugal"}]}],"member":"311","published-online":{"date-parts":[[2025,6,17]]},"reference":[{"volume-title":"The State of World Fisheries and Aquaculture 2024. 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