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Thus, this study provides a comprehensive epidemiological analysis comparing MT in Portuguese dogs, cats and humans. Data were obtained from the Portuguese National Cancer Registry (RON) (2011\u20132021) and Vet\u2010OncoNet (2020\u20132023), utilising standardised oncological classification systems (ICD\u2010O\u20103.2 and Vet\u2010ICD\u2010O\u2010canine\u20101). The results indicate that Melanoma was the most frequently diagnosed MT across all three species, while melanocytomas were common in dogs but rare in cats and humans. A higher incidence rate (IR) for MT was observed in dogs (IR\u2009=\u200916.1) compared to humans (IR\u2009=\u20098.1) and cats (IR\u2009=\u20096.3), and neutered dogs (10.8\u2009years) were diagnosed at significantly older ages than intact ones (9.9\u2009years). Shar\u2010Peis (RR\u2009=\u200914.2,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) had the highest RR compared to mixed\u2010breed dogs, followed closely by Rhodesian Ridgebacks (RR\u2009=\u200912.2,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and Golden Retrievers (RR\u2009=\u20096.4,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Spatial analysis revealed significant clustering of MT cases in humans and dogs, with a strong geographical overlap (BLISA\u2009=\u20090.345,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) in urban regions. This study provides the first epidemiological comparison of MT in these three species in Portugal, underscoring the sentinel role of companion animals in human oncology and the relevance of comparative oncology in translational cancer research.\n                  <\/jats:p>","DOI":"10.1111\/vco.70031","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T06:41:51Z","timestamp":1765435311000},"page":"105-120","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Comparative Study of Melanocytic Tumours: Linking Portuguese Dogs and Cats to Human Cases"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1465-7666","authenticated-orcid":false,"given":"Catarina","family":"Alves Pinto","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinics, ICBAS\u2013School of Medicine and Biomedical Sciences University of Porto  Porto Portugal"},{"name":"Experimental Pathology and Therapeutics Research Group of the Research Center of IPO\u2010Porto  Porto Portugal"}]},{"given":"Ana Isabel","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Departamento de Geografia Faculdade de Letras da Universidade do Porto, Centro de Estudos em Geografia e Ordenamento do Territ\u00f3rio (CEGOT)  Porto Portugal"},{"name":"EPIUnit ITR, Institute of Public Health of the University Porto University of Porto (ISPUP)  Porto Portugal"}]},{"given":"Jo\u00e3o","family":"Niza\u2010Ribeiro","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Para a Investiga\u00e7\u00e3o Integrativa e Translacional em Sa\u00fade Populacional (ITR)  Porto Portugal"},{"name":"Vet\u2010OncoNet, Population Studies Department, ICBAS\u2013School of Medicine and Biomedical Sciences University of Porto  Porto Portugal"}]},{"given":"Carlos Alberto","family":"Palmeira de Sousa","sequence":"additional","affiliation":[{"name":"Experimental Pathology and Therapeutics Research Group of the Research Center of IPO\u2010Porto  Porto Portugal"},{"name":"Clinical Pathology Service (Immunology Department) of the IPO\u2010Porto  Porto Portugal"},{"name":"I3ID and Health School of University Fernando Pessoa  Porto Portugal"}]},{"given":"Katia","family":"Pinello","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Para a Investiga\u00e7\u00e3o Integrativa e Translacional em Sa\u00fade Populacional (ITR)  Porto Portugal"},{"name":"Vet\u2010OncoNet, Population Studies Department, ICBAS\u2013School of Medicine and Biomedical Sciences University of Porto  Porto Portugal"}]},{"given":"Andreia Alexandra","family":"Ferreira Santos","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinics, ICBAS\u2013School of Medicine and Biomedical Sciences University of Porto  Porto Portugal"},{"name":"Animal Science and Study Centre, Food and Agrarian Sciences and Technologies Institute (CECA\u2010ICETA) University 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