{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T02:07:21Z","timestamp":1773022041672,"version":"3.50.1"},"reference-count":52,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["B. Fernandes; 2021\u20102025"],"award-info":[{"award-number":["B. 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While \u2018emollient\n                      <jats:italic>plus<\/jats:italic>\n                      \u2019 formulations are widely used in human atopic dermatitis (hAD), their role in cAD remains underexplored.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>\n                      To evaluate the clinical efficacy and owner\u2010perceived value of a novel emollient\n                      <jats:italic>plus<\/jats:italic>\n                      formulation as a co\u2010adjuvant treatment for cAD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Twenty\u2010one client\u2010owned dogs with controlled, nonseasonal cAD completed the study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      A proof\u2010of\u2010concept, bench\u2010to\u2010bedside study was conducted over 30\u2009days. Dogs received a once\u2010daily application of a novel emollient\n                      <jats:italic>plus<\/jats:italic>\n                      formulation developed in\u2010house. Clinical outcomes were assessed using pruritus Visual Analog Scale (pVAS)10 and Canine Atopic Dermatitis Extent and Severity Index (CADESI)\u201004 scores, alongside skin barrier function parameters (trans epidermal water loss [TEWL] and pH) at the pinnae and inguinal areas. Owners evaluated therapeutic efficacy via the Owner Global Assessment of Treatment Efficacy (OGATE) questionnaire and sensorial acceptability through a survey.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Significant reductions were observed in pVAS10 (4.25\u2009\u00b1\u20091.85 to 3.38\u2009\u00b1\u20091.79;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.016) and CADESI\u201004 (24.62\u2009\u00b1\u200918.48 to 13.43\u2009\u00b1\u20097.44;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02) scores. TEWL (18.63\u2009\u00b1\u200917.33 to 9.56\u2009\u00b1\u200910.75;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.049) and pH (6.07\u2009\u00b1\u20090.97 to 5.41\u2009\u00b1\u20090.71;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01) only had significant reductions at the pinnae. Owner satisfaction was exceptionally high, with 90.47% rating treatment efficacy as \u2018good to excellent\u2019. The sensorial properties of the formulation also received consistently positive ratings.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Relevance<\/jats:title>\n                    <jats:p>This cAD\u2010targeted emollient product demonstrated promising efficacy in reducing pruritus and skin lesions while possibly improving skin barrier function. Its favourable safety profile and high owner satisfaction suggest strong potential for routine clinical use in the management of cAD. Further controlled studies are warranted to confirm efficacy and optimised treatment protocols.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vde.70035","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T08:06:20Z","timestamp":1762416380000},"page":"293-305","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Novel Topical Emollient\n                    <scp>\n                      <i>Plus<\/i>\n                    <\/scp>\n                    for Canine Atopic Dermatitis: A Clinical Trial Assessing Efficacy and User Acceptance"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5398-673X","authenticated-orcid":false,"given":"Beatriz","family":"Fernandes","sequence":"first","affiliation":[{"name":"Faculty of Veterinary Medicine Centre for Interdisciplinary Research in Animal Health (CIISA), Universidade de Lisboa \u2010 Av. Universidade T\u00e9cnica  Lisboa Portugal"},{"name":"Associate Laboratory for Animal and Veterinary Sciences (AL4AnimalS)  Portugal"}]},{"given":"Ant\u00f3nio Caldeira","family":"Mendes","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine Centre for Interdisciplinary Research in Animal Health (CIISA), Universidade de Lisboa \u2010 Av. Universidade T\u00e9cnica  Lisboa Portugal"},{"name":"Associate Laboratory for Animal and Veterinary Sciences (AL4AnimalS)  Portugal"}]},{"given":"Susana Paula","family":"Alves","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine Centre for Interdisciplinary Research in Animal Health (CIISA), Universidade de Lisboa \u2010 Av. Universidade T\u00e9cnica  Lisboa Portugal"},{"name":"Associate Laboratory for Animal and Veterinary Sciences (AL4AnimalS)  Portugal"}]},{"given":"Vanessa","family":"Schmidt","sequence":"additional","affiliation":[{"name":"The University of Liverpool School of Veterinary Science  Neston UK"}]},{"given":"Ana Filipa","family":"Bizarro","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine Centre for Interdisciplinary Research in Animal Health (CIISA), Universidade de Lisboa \u2010 Av. Universidade T\u00e9cnica  Lisboa Portugal"},{"name":"Associate Laboratory for Animal and Veterinary Sciences (AL4AnimalS)  Portugal"}]},{"given":"Marta","family":"Pinto","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine Centre for Interdisciplinary Research in Animal Health (CIISA), Universidade de Lisboa \u2010 Av. Universidade T\u00e9cnica  Lisboa Portugal"},{"name":"Associate Laboratory for Animal and Veterinary Sciences (AL4AnimalS)  Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8005-2043","authenticated-orcid":false,"given":"Hugo","family":"Pereira","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine Centre for Interdisciplinary Research in Animal Health (CIISA), Universidade de Lisboa \u2010 Av. Universidade T\u00e9cnica  Lisboa Portugal"},{"name":"Associate Laboratory for Animal and Veterinary Sciences (AL4AnimalS)  Portugal"}]},{"given":"Joana","family":"Marto","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Prof. Gama Pinto Research Institute for Medicines (iMed.ULisboa), Universidade de Lisboa, Av.  Lisboa Portugal"}]},{"given":"Ana Mafalda","family":"Louren\u00e7o","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine Centre for Interdisciplinary Research in Animal Health (CIISA), Universidade de Lisboa \u2010 Av. 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