{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T14:56:43Z","timestamp":1786460203656,"version":"build-2736575974"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This systematic review will aim to summarize and evaluate the literature describing the evidence regarding adverse events from the administration of nitrates during right ventricular myocardial infarction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>\n                      Withholding nitrates in the setting of right ventricular myocardial infarction is currently recommended by the American Heart Association, European Society of Cardiology, and in the\n                      <jats:italic toggle=\"yes\">Australian Journal of General Practice<\/jats:italic>\n                      , due to the risk that decreasing preload in the setting of already compromised right ventricular ejection fraction may reduce cardiac output and precipitate hypotension or exacerbate cardiogenic shock. The original evidence from 1989 underpinning these recommendations displays methodological weaknesses including low sample size and confounding interventions. More recent and comprehensive research from 2014, 2016, 2018, and 2019 conflicts with the conclusions from the 1989 study, suggesting instead that nitrate administration during right ventricular myocardial infarction results in no significant difference in the rate of adverse events. The combination of recommended practice based on 30-year-old evidence and the emergence of recent challenging evidence suggest that this topic merits systematic review.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Inclusion criteria:<\/jats:title>\n                    <jats:p>The study will include both experimental and observational (descriptive and analytical) study designs that discuss the occurrence of adverse events from the administration of nitrates during a known right ventricular myocardial infarction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Six databases will be systematically searched: the Cochrane CENTRAL Register, PubMed, Embase, MEDLINE Complete, CINAHL, and Google Scholar. Identified studies will be independently assessed for inclusion by two investigators using JBI critical appraisal tools. Data will be extracted for narrative and tabular synthesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Systematic review registration number:<\/jats:title>\n                    <jats:p>PROSPERO CRD42020172839<\/jats:p>\n                  <\/jats:sec>","DOI":"10.11124\/jbies-20-00183","type":"journal-article","created":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T20:23:50Z","timestamp":1616185430000},"page":"2415-2422","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Adverse events from nitrate administration during right ventricular myocardial infarction: a systematic review protocol"],"prefix":"10.11124","volume":"19","author":[{"given":"Matt","family":"Wilkinson-Stokes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Colbeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,9]]},"reference":[{"issue":"(10065)","key":"R1-20250613","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0140-6736(16)30677-8","article-title":"Acute myocardial infarction","volume":"389","author":"Reed","year":"2017","journal-title":"Lancet"},{"issue":"(1)","key":"R2-20250613","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1253\/circj.CJ-11-1133","article-title":"Nitroglycerin use in myocardial infarction patients","volume":"76","author":"Ferreira","year":"2012","journal-title":"Circ J"},{"issue":"(8951)","key":"R4-20250613","first-page":"669","article-title":"ISIS-4: A randomised factorial trial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulphate in 58 050 patients with suspected acute myocardial infarction","volume":"345","year":"1995","journal-title":"Lancet"},{"issue":"(2)","key":"R5-20250613","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0735-1097(95)00498-X","article-title":"Six-month effects of early treatment with lisinopril and transdermal glyceryl trinitrate singly and together withdrawn six weeks atter acute myocardial infarction: The GISSI-3 trial","volume":"27","author":"Miocardico","year":"1996","journal-title":"J Am Coll Cardiol"},{"issue":"(5)","key":"R6-20250613","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1517\/14740338.5.5.667","article-title":"Side effects of using nitrates to treat angina","volume":"5","author":"Thadani","year":"2006","journal-title":"Expert Opin Drug Saf"},{"issue":"(9)","key":"R7-20250613","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.hlc.2016.06.789","article-title":"National Heart Foundation of Australia; Cardiac Society of Australia and New Zealand: Australian Clinical guidelines for the management of acute coronary syndromes 2016","volume":"25","author":"Chew","year":"2016","journal-title":"Hear Lung Circ"},{"issue":"(2)","key":"R8-20250613","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/eurheartj\/ehx393","article-title":"2017 ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation","volume":"39","author":"Ibanez","year":"2018","journal-title":"Eur Heart J"},{"issue":"(1)","key":"R10-20250613","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1001\/archinte.1932.00150140138008","article-title":"Myocardial infarction or gross necrosis: analysis of one hundred necropsies","volume":"50","author":"Lisa","year":"1932","journal-title":"Arch Intern Med"},{"issue":"(2)","key":"R11-20250613","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0002-9149(74)90276-8","article-title":"Right ventricular infarction: clinical and hemodynamic features","volume":"33","author":"Cohn","year":"1974","journal-title":"Am J Cardiol"},{"issue":"(9)","key":"R12-20250613","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1136\/hrt.36.9.941","article-title":"Right ventricular infarction: a haemodynamic diagnosis","volume":"36","author":"Rotman","year":"1974","journal-title":"Heart"},{"issue":"(3)","key":"R13-20250613","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/0002-9149(79)90001-8","article-title":"Right ventricular infarction. Clinical diagnosis and differentiation from cardiac tamponade and pericardial constriction","volume":"43","author":"Lorell","year":"1979","journal-title":"Am J Cardiol"},{"issue":"(6)","key":"R14-20250613","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/0002-9149(81)90314-3","article-title":"Hemodynamic spectrum of \u201cdominant\u201d right ventricular infarction in 19 patients","volume":"48","author":"Lloyd","year":"1981","journal-title":"Am J Cardiol"},{"issue":"(7)","key":"R15-20250613","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1080\/14779072.2018.1489234","article-title":"Acute right ventricular myocardial infarction","volume":"16","author":"Albulushi","year":"2018","journal-title":"Expert Rev Cardiovasc Ther"},{"issue":"(18)","key":"R16-20250613","first-page":"S501","article-title":"Part 10: Special circumstances of resuscitation: 2015 American Heart Association guidelines update for cardiopulmonary resuscitation and emergency cardiovascular care","volume":"132","author":"Lavonas","year":"2015","journal-title":"Circulation"},{"issue":"(5)","key":"R17-20250613","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0002-9149(89)90525-0","article-title":"Significance of nitroglycerin-induced hypotension with inferior wall acute myocardial infarction","volume":"64","author":"Ferguson","year":"1989","journal-title":"Am J Cardiol"},{"key":"R18-20250613","first-page":"bcr2014204494","article-title":"Isolated RV myocardial infarction presenting with systemic hypertension minimally responsive to nitroglycerin","volume":"2014","author":"Parekh","year":"2014","journal-title":"Case Reports"},{"issue":"(1)","key":"R19-20250613","doi-asserted-by":"crossref","first-page":"76","DOI":"10.3109\/10903127.2015.1037480","article-title":"Prehospital nitroglycerin safety in inferior ST elevation myocardial infarction","volume":"20","author":"Robichaud","year":"2016","journal-title":"Prehospital Emerg Care"},{"issue":"(S1)","key":"R20-20250613","doi-asserted-by":"crossref","first-page":"S39","DOI":"10.1017\/cem.2017.95","article-title":"LO33: Prehospital adverse events associated with nitroglycerin use in STEMI patients with right ventricle infarction","volume":"19","author":"McConnell","year":"2017","journal-title":"CJEM"},{"issue":"(5)","key":"R21-20250613","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1080\/10903127.2018.1558318","article-title":"Safety and Effectiveness of field nitroglycerin in patients with suspected ST elevation myocardial infarction","volume":"23","author":"Bosson","year":"2019","journal-title":"Prehospital Emerg Care"},{"issue":"(6)","key":"R25-20250613","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1136\/ip.2008.019430","article-title":"What is lost when searching only one literature database for articles relevant to injury prevention and safety promotion?","volume":"14","author":"Lawrence","year":"2008","journal-title":"Inj Prev"},{"issue":"(6)","key":"R26-20250613","first-page":"848","article-title":"EMBASE versus MEDLINE for family medicine searches: can MEDLINE searches find the forest or a tree?","volume":"51","author":"Wilkins","year":"2005","journal-title":"Can Fam Physician"},{"key":"R27-20250613","doi-asserted-by":"crossref","DOI":"10.1038\/npre.2011.2101.3","article-title":"In search of the right literature search engine(s)","author":"Bajpai","year":"2011","journal-title":"Nat Preced"},{"key":"R28-20250613","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1472-6947-13-7","article-title":"Is the coverage of Google Scholar enough to be used alone for systematic reviews","volume":"13","author":"Jean-Fran\u00e7ois","year":"2013","journal-title":"BMC Med Inform Decis Mak"},{"issue":"(10)","key":"R29-20250613","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.jclinepi.2009.06.005","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"62","author":"Moher","year":"2009","journal-title":"J Clin Epidemiol"},{"issue":"(1)","key":"R30-20250613","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1471-2288-7-4","article-title":"Worked examples of alternative methods for the synthesis of qualitative and quantitative research in systematic reviews","volume":"7","author":"Lucas","year":"2007","journal-title":"BMC Med Res Methodol"},{"issue":"(1)","key":"R31-20250613","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/jebm.12018","article-title":"Understanding GRADE: an introduction","volume":"6","author":"Goldet","year":"2013","journal-title":"J Evid Based Med"}],"container-title":["JBI Evidence Synthesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.11124\/JBIES-20-00183","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T12:35:19Z","timestamp":1786451719000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.11124\/JBIES-20-00183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,17]]},"references-count":26,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.11124\/jbies-20-00183","relation":{},"ISSN":["2689-8381"],"issn-type":[{"value":"2689-8381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,17]]}}}