{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T14:56:43Z","timestamp":1786460203868,"version":"build-2736575974"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The objective of this review is to evaluate the effectiveness of technology-based interventions in relieving procedural pain in hospitalized neonates compared with other non-pharmacological interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Neonates requiring hospital care often experience acute pain during medical procedures. The current best practice for relieving pain in neonates is the use of non-pharmacological interventions, such as oral solutions or intervention-based human touch. Technological solutions (such as games, eHealth applications, and mechanical vibrators) have become more commonplace in pediatric pain management over recent years. However, there is a knowledge gap about how effective technology-based interventions are at relieving pain in neonates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Inclusion criteria:<\/jats:title>\n                    <jats:p>This review will consider experimental trials that include technology-based non-pharmacological interventions for relieving procedural pain in hospitalized neonates. Primary outcomes of interest include pain response to a procedure measured by a validated pain assessment scale for neonates, behavioral indicators, and\/or changes in physiological indicators.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>MEDLINE (Ovid), CINAHL (EBSCO), Scopus (Elsevier), Cochrane Central Register of Controlled Trials, and the MEDIC databases will be searched for studies published in English, Finnish, and Swedish. Critical appraisal and data extraction will be conducted by two independent researchers following JBI methodology. Quantitative data will be pooled in statistical meta-analyses. If statistical analysis is not possible, the findings will be reported narratively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Systematic review registration:<\/jats:title>\n                    <jats:p>PROSPERO CRD42021254218<\/jats:p>\n                  <\/jats:sec>","DOI":"10.11124\/jbies-21-00010","type":"journal-article","created":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T13:04:53Z","timestamp":1627304693000},"page":"2770-2776","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Effectiveness of technology-based interventions compared with other non-pharmacological interventions for relieving procedural pain in hospitalized neonates: a systematic review protocol"],"prefix":"10.11124","volume":"19","author":[{"given":"Anna-Kaija","family":"Palomaa","sequence":"first","affiliation":[{"name":"Research Unit of Nursing Science and Health Management, University of Oulu, Oulu, Finland"},{"name":"Finnish Centre for Evidence-Based Health Care: A JBI Centre of Excellence, Helsinki, Finland"},{"name":"Oulu University Hospital, Oulu, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna-Maria","family":"Tuomikoski","sequence":"additional","affiliation":[{"name":"Finnish Centre for Evidence-Based Health Care: A JBI Centre of Excellence, Helsinki, Finland"},{"name":"Oulu University of Applied Sciences, Oulu, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saija","family":"Huhtala","sequence":"additional","affiliation":[{"name":"Research Unit of Nursing Science and Health Management, University of Oulu, Oulu, Finland"},{"name":"Finnish Centre for Evidence-Based Health Care: A JBI Centre of Excellence, Helsinki, Finland"},{"name":"Oulu University Hospital, Oulu, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarja","family":"P\u00f6lkki","sequence":"additional","affiliation":[{"name":"Research Unit of Nursing Science and Health Management, University of Oulu, Oulu, Finland"},{"name":"Finnish Centre for Evidence-Based Health Care: A JBI Centre of Excellence, Helsinki, Finland"},{"name":"Oulu University Hospital, Oulu, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,10]]},"reference":[{"key":"R1-20250613","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3389\/fped.2020.00030","article-title":"Early neonatal pain: a review of clinical and experimental implications on painful conditions later in life","volume":"8","author":"Williams","year":"2020","journal-title":"Front Pediatr"},{"issue":"(5)","key":"R2-20250613","first-page":"260","article-title":"Variation in NICU admission rates without identifiable cause","volume":"6","author":"Ziegler","year":"2016","journal-title":"Hosp Pediatr"},{"issue":"(1)","key":"R3-20250613","first-page":"e46","article-title":"Global, regional, and national estimates of levels of preterm birth in 2014: a systematic review and modelling analysis","volume":"7","author":"Chawanpaiboon","year":"2019","journal-title":"Lancet Glob Health"},{"issue":"(4)","key":"R4-20250613","first-page":"498","article-title":"Epidemiology of painful procedures performed in neonates: a systematic review of observational studies","volume":"20","author":"Cruz","year":"2016","journal-title":"Eur J Pain"},{"issue":"(3)","key":"R5-20250613","first-page":"226","article-title":"Eight years later, are we still hurting newborn infants?","volume":"105","author":"Roofthooft","year":"2014","journal-title":"Neonatology"},{"issue":"(6)","key":"R6-20250613","first-page":"1277","article-title":"Quantification of neonatal procedural pain severity: a platform for estimating total pain burden in individual infants","volume":"161","author":"Laudiano-Dray","year":"2020","journal-title":"Pain"},{"issue":"(2)","key":"R7-20250613","first-page":"e20154271","article-title":"Committee on Fetus and Newborn and Section on Anesthesiology and Pain Medicine. 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