{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T14:55:33Z","timestamp":1786460133709,"version":"build-2736575974"},"reference-count":57,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The aim of this umbrella review was to assess the effectiveness of oral appliance therapy compared to continuous positive airway pressure (CPAP), surgery, inactive appliances\/controls, exercise, or other conservative techniques in mitigating symptoms among adults diagnosed with obstructive sleep apnea.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Sleep-disordered breathing encompasses a spectrum of recurrent episodes of upper airway narrowing during sleep, marked by symptoms such as snoring, heightened upper airway resistance, or obstructive sleep apnea. The management of obstructive sleep apnea involves a range of conservative and surgical approaches. Among conservative methods, oral appliances are the preferred treatment for primary snoring, mild to moderate cases, and severe cases in patients who are intolerant to CPAP. While several systematic reviews have explored the effectiveness of oral appliance therapy for obstructive sleep apnea, there has been no comprehensive evaluation or synthesis of these reviews.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Inclusion criteria:<\/jats:title>\n                    <jats:p>Systematic reviews, with or without meta-analysis, were examined to assess the effectiveness of various forms of oral appliances in treating obstructive sleep apnea. Polysomnography was employed as the method for evaluating the effectiveness of the appliance. The primary outcome of interest was the effectiveness of oral appliance therapy in reducing the apnea-hypopnea index. Secondary outcomes included the mean change in the respiratory arousal index, Epworth Sleepiness Scale scores, minimum oxygen saturation, sleep efficiency, rapid eye movement sleep, blood pressure, quality of life, patient preference, and adverse effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A comprehensive search was conducted up to October 2023 in MEDLINE (Ovid), CINAHL (EBSCOhost), Scopus, Web of Science Core Collection, Epistemonikos, ProQuest Dissertations and Theses, Shodhganga, and the Cochrane Database of Systematic Reviews. Supplementary searches were manually performed using Google Scholar. The critical appraisal and data extraction processes were carried out independently by 2 reviewers. The extracted data were summarized using a tabular format accompanied by supporting text. The quality of evidence was evaluated utilizing the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>This umbrella review incorporated 27 systematic reviews published between 2004 and 2022. The primary studies in these systematic reviews were published between 1996 and 2021. Of the 68 primary studies, 50 were published between 1996 and 2014 and 18 were published between 2015 and 2021. The corrected covered area index was 15.04%, indicating very high overlap between the primary studies included in the systematic reviews. All systematic reviews that compared oral appliances with CPAP consistently reported that CPAP was more efficacious, evidenced by a decrease in the apnea-hypopnea index, respiratory arousal index, and improved minimum oxygen saturation levels. However, patient preference favored oral appliances over CPAP. Additionally, oral appliances demonstrated improvements in subjective sleepiness scores and indices including the apnea-hypopnea index and respiratory arousal index when compared with inactive appliances\/controls. The overall quality of evidence using GRADE ranged from very low to moderate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>CPAP demonstrated greater efficacy than oral appliances in reducing the apnea-hypopnea index and respiratory arousal index while increasing minimum oxygen saturation levels, indicating significant improvements in obstructive sleep apnea and contributing to enhanced sleep quality and overall health. Despite these advantages, patient preference often leans toward oral appliances over CPAP. Compared with inactive appliances\/controls, surgery, and other conservative management approaches, oral appliances have also shown efficacy in improving obstructive sleep apnea. This umbrella review reinforces CPAP as the gold standard for obstructive sleep apnea treatment, although oral appliances represent a viable alternative, particularly for patients who experience difficulties in accessing or tolerating CPAP. The majority of included systematic reviews were published over a decade ago, highlighting a research gap in this area; therefore, future studies should focus on comparing newer treatment options for obstructive sleep apnea.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.11124\/jbies-23-00539","type":"journal-article","created":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T04:46:42Z","timestamp":1743396402000},"page":"876-919","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Oral appliance therapy for the management of obstructive sleep apnea in adults: an umbrella review"],"prefix":"10.11124","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4801-4594","authenticated-orcid":false,"given":"Parvathy","family":"Ghosh","sequence":"first","affiliation":[{"name":"Department of Orthodontics and Dentofacial Orthopedics, Amrita School of Dentistry, Amrita Vishwa Vidyapeetham University, Kochi, Kerala, India"},{"name":"Amrita Centre for Evidence Based Oral Health: A JBI Centre of Excellence, Ernakulam, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1907-8708","authenticated-orcid":false,"given":"Chandrashekar","family":"Janakiram","sequence":"additional","affiliation":[{"name":"Amrita Centre for Evidence Based Oral Health: A JBI Centre of Excellence, Ernakulam, Kerala, India"},{"name":"Department of Public Health Dentistry, Amrita School of Dentistry, Amrita Vishwa Vidyapeetham University, Kochi, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9644-1123","authenticated-orcid":false,"given":"Sapna Varma","family":"NK","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Dentofacial Orthopedics, Amrita School of Dentistry, Amrita Vishwa Vidyapeetham University, Kochi, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4171-8129","authenticated-orcid":false,"given":"Sarika","family":"K","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Dentofacial Orthopedics, Amrita School of Dentistry, Amrita Vishwa Vidyapeetham University, Kochi, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajith","family":"VV","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Dentofacial Orthopedics, Amrita School of Dentistry, Amrita Vishwa Vidyapeetham University, Kochi, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,3,31]]},"reference":[{"issue":"9","key":"R1-20260406","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1093\/aje\/kws342","article-title":"Increased prevalence of sleep-disordered breathing in adults","volume":"177","author":"Peppard","year":"2013","journal-title":"Am J Epidemiol"},{"issue":"5","key":"R2-20260406","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.acvd.2020.01.003","article-title":"Obstructive sleep apnoea and cardiovascular consequences: Pathophysiological mechanisms","volume":"113","author":"Arnaud","year":"2020","journal-title":"Arch Cardiovasc Dis"},{"issue":"8","key":"R3-20260406","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S2213-2600(19)30198-5","article-title":"Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis","volume":"7","author":"Benjafield","year":"2019","journal-title":"Lancet Respir Med"},{"issue":"5","key":"R4-20260406","doi-asserted-by":"crossref","first-page":"784","DOI":"10.4103\/ijdr.IJDR_224_19","article-title":"Epidemiological study on prevalent risk factors and craniofacial skeletal patterns in obstructive sleep apnea among South Indian population","volume":"31","author":"Ghosh","year":"2020","journal-title":"Indian J Dent Res"},{"key":"R5-20260406","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.sleep.2015.01.015","article-title":"Disparities and genetic risk factors in obstructive sleep apnea","volume":"18","author":"Dudley","year":"2016","journal-title":"Sleep Med"},{"key":"R6-20260406","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.smrv.2018.01.003","article-title":"The impact of ethnicity on the prevalence and severity of obstructive sleep apnea","volume":"41","author":"Hnin","year":"2018","journal-title":"Sleep Med Rev"},{"issue":"2","key":"R7-20260406","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1513\/pats.200707-114MG","article-title":"Pathophysiology of adult obstructive sleep apnea","volume":"5","author":"Eckert","year":"2008","journal-title":"Proc Am Thorac Soc"},{"issue":"3","key":"R8-20260406","doi-asserted-by":"crossref","first-page":"479","DOI":"10.5664\/jcsm.6506","article-title":"Clinical practice guideline for diagnostic testing for adult obstructive sleep apnea: an American Academy of Sleep Medicine Clinical Practice Guideline","volume":"13","author":"Kapur","year":"2017","journal-title":"J Clin Sleep Med"},{"key":"R9-20260406","doi-asserted-by":"crossref","first-page":"21","DOI":"10.2147\/NSS.S124657","article-title":"Obstructive sleep apnea: current perspectives","volume":"23","author":"Osman","year":"2018","journal-title":"Nat Sci Sleep"},{"issue":"7","key":"R10-20260406","doi-asserted-by":"crossref","first-page":"773","DOI":"10.5664\/jcsm.4858","article-title":"Clinical practice guideline for the treatment of obstructive sleep apnea and snoring with oral appliance therapy: an update for 2015","volume":"11","author":"Ramar","year":"2015","journal-title":"J Clin Sleep Med"},{"issue":"14","key":"R11-20260406","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1001\/jama.2020.3514","article-title":"Diagnosis and management of obstructive sleep apnea: a review","volume":"323","author":"Gottlieb","year":"2020","journal-title":"JAMA"},{"issue":"2","key":"R12-20260406","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s11325-012-0721-3","article-title":"Treatment of obstructive sleep apnea using a custom-made titratable duobloc oral appliance: a prospective clinical study","volume":"17","author":"Dieltjens","year":"2013","journal-title":"Sleep Breath"},{"issue":"1","key":"R13-20260406","first-page":"CD004435","article-title":"Oral appliances for obstructive sleep apnoea","author":"Lim","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"issue":"12","key":"R14-20260406","first-page":"200","article-title":"Oral Interventions for Obstructive Sleep Apnea","volume":"115","author":"Koretsi","year":"2018","journal-title":"Dtsch Arztebl Int"},{"issue":"4","key":"R15-20260406","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.chest.2017.01.020","article-title":"Effects of CPAP and mandibular advancement devices on health-related quality of life in OSA: a systematic review and meta-analysis","volume":"151","author":"Kuhn","year":"2017","journal-title":"Chest"},{"issue":"4","key":"R16-20260406","first-page":"e417","article-title":"Mandibular advancement devices vs nasal-continuous positive airway pressure in the treatment of obstructive sleep apnoea. Systematic review and meta-analysis","volume":"22","author":"Cammaroto","year":"2017","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"R17-20260406","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.sleep.2016.06.001","article-title":"Comparative efficacy of CPAP, MADs, exercise-training and dietary weight loss for sleep apnea: a network meta-analysis","volume":"30","author":"Iftikhar","year":"2017","journal-title":"Sleep Med"},{"issue":"3","key":"R18-20260406","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s11325-017-1590-6","article-title":"Effects of CPAP and mandibular advancement device treatment in obstructive sleep apnea patients: a systematic review and meta-analysis","volume":"22","author":"Schwartz","year":"2018","journal-title":"Sleep Breath"},{"key":"R19-20260406","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.sleep.2020.03.015","article-title":"Continuous positive airway pressure versus mandibular advancement device in the treatment of obstructive sleep apnea: a systematic review and meta-analysis","volume":"72","author":"Li","year":"2020","journal-title":"Sleep Med"},{"issue":"6","key":"R20-20260406","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1080\/08869634.2018.1475278","article-title":"Effectiveness of oral appliances versus continuous positive airway pressure in treatment of OSA patients: an updated meta-analysis","volume":"37","author":"Zhang","year":"2019","journal-title":"Cranio"},{"key":"R21-20260406","doi-asserted-by":"crossref","first-page":"6676158","DOI":"10.1155\/2021\/6676158","article-title":"Clinical evidence in the treatment of obstructive sleep apnoea with oral appliances: a systematic review","volume":"2021","author":"Rossi","year":"2021","journal-title":"Int J Dent"},{"issue":"8","key":"R23-20260406","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.11124\/JBIES-22-00220","article-title":"Oral appliance therapy for the management of obstructive sleep apnea in adults: an umbrella review protocol","volume":"21","author":"Ghosh","year":"2023","journal-title":"JBI Evid Synth"},{"key":"R24-20260406","first-page":"372:n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"R25-20260406","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/2047-2382-4-2","article-title":"What are \u2018integrated landscape approaches\u2019 and how effectively have they been implemented in the tropics: a systematic map protocol","volume":"4","author":"Reed","year":"2015","journal-title":"Environ Evid"},{"issue":"4","key":"R26-20260406","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.jclinepi.2013.11.007","article-title":"Systematic review finds overlapping reviews were not mentioned in every other overview","volume":"67","author":"Pieper","year":"2014","journal-title":"J Clin Epidemiol"},{"issue":"3","key":"R27-20260406","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/jrsm.1557","article-title":"Graphical representation of overlap for overviews: GROOVE tool","volume":"13","author":"Bracchiglione","year":"2022","journal-title":"Res Synth Methods"},{"issue":"3","key":"R28-20260406","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1097\/XEB.0000000000000055","article-title":"Summarizing systematic reviews: methodological development, conduct and reporting of an umbrella review approach","volume":"13","author":"Aromataris","year":"2015","journal-title":"Int J Evid Based Healthc"},{"issue":"9","key":"R29-20260406","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1007\/s10654-019-00531-4","article-title":"A critical reflection on the grading of the certainty of evidence in umbrella reviews","volume":"34","author":"Schlesinger","year":"2019","journal-title":"Eur J Epidemiol"},{"issue":"5","key":"R30-20260406","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.ajodo.2010.01.030","article-title":"Subjective efficacy of oral appliance design features in the management of obstructive sleep apnea: a systematic review","volume":"138","author":"Ahrens","year":"2010","journal-title":"Am J Orthod Dentofacial Orthop"},{"issue":"11","key":"R31-20260406","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/S2213-2600(15)00416-6","article-title":"Comparison of the effects of continuous positive airway pressure and mandibular advancement devices on sleepiness in patients with obstructive sleep apnoea: a network meta-analysis","volume":"3","author":"Bratton","year":"2015","journal-title":"Lancet Respir Med"},{"issue":"4","key":"R32-20260406","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.jfma.2018.02.008","article-title":"Short-term efficacy of minimally invasive treatments for adult obstructive sleep apnea: a systematic review and network meta-analysis of randomized controlled trials","volume":"118","author":"Gao","year":"2019","journal-title":"J Formos Med Assoc"},{"issue":"3","key":"R33-20260406","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1177\/154411130401500303","article-title":"Efficacy and co-morbidity of oral appliances in the treatment of obstructive sleep apnea-hypopnea: a systematic review","volume":"15","author":"Hoekema","year":"2004","journal-title":"Crit Rev Oral Biol Med"},{"issue":"7","key":"R34-20260406","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.4187\/respcare.02245","article-title":"The comparison of CPAP and oral appliances in treatment of patients with OSA: a systematic review and meta-analysis","volume":"58","author":"Li","year":"2013","journal-title":"Respir Care"},{"issue":"7","key":"R35-20260406","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1111\/joor.12162","article-title":"The effect of oral appliances that advanced the mandible forward and limited mouth opening in patients with obstructive sleep apnea: a systematic review and meta-analysis of randomised controlled trials","volume":"41","author":"Okuno","year":"2014","journal-title":"J Oral Rehabil"},{"issue":"12","key":"R36-20260406","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1016\/j.jdent.2015.10.008","article-title":"The effectiveness of oral appliances for obstructive sleep apnea syndrome: a meta-analysis","volume":"43","author":"Zhu","year":"2015","journal-title":"J Dent"},{"issue":"3","key":"R37-20260406","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1093\/ejo\/cjq079","article-title":"A systematic review of the efficacy of oral appliance design in the management of obstructive sleep apnoea","volume":"33","author":"Ahrens","year":"2011","journal-title":"Eur J Orthod"},{"issue":"7","key":"R38-20260406","doi-asserted-by":"crossref","first-page":"zsab015","DOI":"10.1093\/sleep\/zsab015","article-title":"Health outcomes of continuous positive airway pressure versus mandibular advancement device for the treatment of severe obstructive sleep apnea: an individual participant data meta-analysis","volume":"44","author":"Trzepizur","year":"2021","journal-title":"Sleep"},{"key":"R39-20260406","doi-asserted-by":"crossref","first-page":"289","DOI":"10.3389\/fneur.2017.00289","article-title":"Verifying the relative efficacy between continuous positive airway pressure therapy and its alternatives for obstructive sleep Apnea: a network meta-analysis","volume":"8","author":"Liu","year":"2017","journal-title":"Front Neurol"},{"issue":"1","key":"R40-20260406","first-page":"e21759","article-title":"Continuous positive airway pressure vs mandibular advancement devices in the treatment of obstructive sleep apnea: an updated systematic review and meta-analysis","volume":"14","author":"Pattipati","year":"2022","journal-title":"Cureus"},{"issue":"5","key":"R41-20260406","doi-asserted-by":"crossref","first-page":"1901945","DOI":"10.1183\/13993003.01945-2019","article-title":"Obstructive sleep apnoea treatment and blood pressure: which phenotypes predict a response? A systematic review and meta-analysis","volume":"55","author":"Pengo","year":"2020","journal-title":"Eur Respir J"},{"issue":"21","key":"R42-20260406","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1001\/jama.2015.16303","article-title":"CPAP vs mandibular advancement devices and blood pressure in patients with obstructive sleep apnea a systematic review and meta-analysis","volume":"314","author":"Bratton","year":"2015","journal-title":"JAMA"},{"key":"R43-20260406","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.smrv.2017.10.004","article-title":"Cardiovascular effects of oral appliance therapy in obstructive sleep apnea: a systematic review and meta-analysis","volume":"40","author":"de Vries","year":"2018","journal-title":"Sleep Med Rev"},{"key":"R44-20260406","first-page":"CD001106","article-title":"Continuous positive airways pressure for obstructive sleep apnoea in adults","volume":"1","author":"Giles","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"R45-20260406","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.smrv.2015.05.003","article-title":"Meta-analysis of randomised controlled trials of oral mandibular advancement devices and continuous positive airway pressure for obstructive sleep apnoea-hypopnoea","volume":"27","author":"Sharples","year":"2016","journal-title":"Sleep Med Rev"},{"issue":"7","key":"R46-20260406","first-page":"621","article-title":"Continuous positive airway pressure and oral appliances on treatment of obstructive sleep apnea hypopnea syndrome: a meta-analysis","volume":"43","author":"Zhang","year":"2018","journal-title":"Med J Chinese Peoples Liberation Army"},{"issue":"6","key":"R47-20260406","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.smrv.2009.02.004","article-title":"A systematic review of continuous positive airway pressure for obstructive sleep apnoea-hypopnoea syndrome","volume":"13","author":"McDaid","year":"2009","journal-title":"Sleep Med Rev"},{"issue":"4","key":"R48-20260406","doi-asserted-by":"crossref","first-page":"314","DOI":"10.4103\/jips.jips_261_22","article-title":"To compare different non-surgical treatment modalities on treatment of obstructive sleep apnea: a systematic review and meta-analysis","volume":"22","author":"Vimal","year":"2022","journal-title":"J Indian Prosthodont Soc"},{"issue":"2","key":"R49-20260406","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1007\/s11883-011-0161-8","article-title":"Obstructive sleep apnea and the risk for cardiovascular disease","volume":"13","author":"Kohli","year":"2011","journal-title":"Curr Atheroscler Rep"},{"issue":"2","key":"R50-20260406","doi-asserted-by":"crossref","first-page":"215","DOI":"10.5664\/jcsm.3460","article-title":"Oral appliance treatment for obstructive sleep apnea: an update","volume":"10","author":"Sutherland","year":"2014","journal-title":"J Clin Sleep Med"},{"issue":"3","key":"R51-20260406","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.jsmc.2014.06.002","article-title":"Advances in positive airway pressure treatment modalities for hypoventilation syndromes","volume":"9","author":"Combs","year":"2014","journal-title":"Sleep Med Clin"},{"issue":"2","key":"R52-20260406","first-page":"CD001106","article-title":"Continuous positive airways pressure for obstructive sleep apnoea","author":"White","year":"2001","journal-title":"Cochrane Database Syst Rev"},{"issue":"1","key":"R53-20260406","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1038\/ctg.2013.13","article-title":"A primer on effectiveness and efficacy trials","volume":"5","author":"Singal","year":"2014","journal-title":"Clin Transl Gastroenterol"},{"issue":"3","key":"R54-20260406","doi-asserted-by":"crossref","first-page":"271","DOI":"10.5664\/jcsm.2500","article-title":"Obstructive sleep apnea and oxygen therapy: a systematic review of the literature and meta-analysis","volume":"9","author":"Mehta","year":"2013","journal-title":"J Clin Sleep Med"},{"issue":"3","key":"R55-20260406","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.jsmc.2021.05.001","article-title":"Sleep and cardiovascular risk","volume":"16","author":"Korostovtseva","year":"2021","journal-title":"Sleep Med Clin"},{"issue":"3","key":"R56-20260406","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1001\/archotol.1997.01900030025003","article-title":"Long-term follow-up of patients with obstructive sleep apnea treated with uvulopalatopharyngoplasty","volume":"123","author":"Janson","year":"1997","journal-title":"Arch Otolaryngol Head Neck Surg"},{"issue":"6","key":"R57-20260406","doi-asserted-by":"crossref","first-page":"426","DOI":"10.14639\/0392-100X-959","article-title":"Drug-induced sleep endoscopy as a selection tool for mandibular advancement therapy by oral device in patients with mild to moderate obstructive sleep apnoea","volume":"35","author":"De Corso","year":"2015","journal-title":"Acta Otorhinolaryngol Ital"},{"issue":"6","key":"R58-20260406","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1590\/s1806-37562016000000156","article-title":"The role of physical exercise in obstructive sleep apnea","volume":"42","author":"de Andrade","year":"2016","journal-title":"J Bras Pneumol"}],"container-title":["JBI Evidence Synthesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.11124\/JBIES-23-00539","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T12:32:51Z","timestamp":1786451571000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.11124\/JBIES-23-00539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,31]]},"references-count":57,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.11124\/jbies-23-00539","relation":{},"ISSN":["2689-8381"],"issn-type":[{"value":"2689-8381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,31]]}}}