{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T14:57:02Z","timestamp":1786460222963,"version":"build-2736575974"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The objective of this systematic review will be to evaluate the effectiveness of the bilayered dermal substitute, Biodegradable Temporising Matrix (BTM), compared with other wound management options in improving clinical outcomes for adults with wounds requiring surgical intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Dermal substitutes provide physiological wound cover for major burns, traumatic wounds, necrotizing fasciitis, diabetes, oncological resections, and previously non-graftable wound beds. Bilayered dermal substitutes such as BTM are designed to provide immediate coverage to an area of skin loss, with subsequent skin grafting to restore structure and function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Eligibility criteria:<\/jats:title>\n                    <jats:p>This review will consider studies on adult patients (18 years or older) with wounds of any etiology or severity requiring surgical intervention. Studies will be considered if they evaluate surgical treatment for wounds using BTM, with or without negative pressure wound therapy, compared with any other surgical technique.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This review will adhere to the JBI methodology for systematic reviews of effectiveness. The following databases will be searched for published studies: PubMed, Embase (Ovid), and CINAHL Ultimate (EBSCOhost). Unpublished studies, gray literature, conference presentations, and posters will also be considered. The searches will be conducted from database inception till the present, with no language limitations. Two reviewers will independently screen titles and abstracts against the eligibility criteria, followed by full-text screening. Eligible studies will be critically appraised at the outcome\/result level for methodological quality using JBI\u2019s standardized critical appraisal instruments. Data will be extracted and pooled in statistical meta-analysis. The results will be reported in tables, visual format, and narrative format.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Review registration:<\/jats:title>\n                    <jats:p>PROSPERO CRD42024595778<\/jats:p>\n                  <\/jats:sec>","DOI":"10.11124\/jbies-24-00464","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T12:01:04Z","timestamp":1763553664000},"page":"150-157","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness of bilayered dermal substitutes for wound healing in adults: a systematic review protocol"],"prefix":"10.11124","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9121-161X","authenticated-orcid":false,"given":"Lauren","family":"Middleton","sequence":"first","affiliation":[{"name":"JBI, School of Public Health, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3805-4752","authenticated-orcid":false,"given":"Elias","family":"Awwad","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1624-4371","authenticated-orcid":false,"given":"Elizabeth","family":"Concannon","sequence":"additional","affiliation":[{"name":"Burns Unit, Royal Adelaide Hospital, Adelaide, SA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7238-5833","authenticated-orcid":false,"given":"Edoardo","family":"Aromataris","sequence":"additional","affiliation":[{"name":"JBI, School of Public Health, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, 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