{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T15:00:28Z","timestamp":1786460428219,"version":"build-2736575974"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The aim of the scoping review is to elucidate challenges in mass drug administration programs with ivermectin to control or eliminate onchocerciasis in endemic countries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>\n                      The filarial nematode\n                      <jats:italic toggle=\"yes\">Onchocerca volvulus<\/jats:italic>\n                      causes onchocerciasis, a neglected tropical disease that can lead to blindness. Although ivermectin, a potent antifilarial drug, was introduced in 1991 and has been used successfully in mass drug administration programs, complex challenges have prevented the elimination of onchocerciasis, a goal set by the World Health Organization in 2009. A comprehensive understanding of these challenges could help program managers and policymakers better target their efforts to control and eliminate onchocerciasis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Eligibility criteria:<\/jats:title>\n                    <jats:p>This review will consider literature that includes individuals affected by onchocerciasis who are living in endemic countries. Literature describing the challenges of implementing mass drug administration programs with ivermectin to control or eliminate onchocerciasis will be considered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The review will be conducted according to the JBI methodology for scoping reviews and reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR). MEDLINE (Ovid), Web of Science Core Collection, CINAHL (EBSCOhost), Cochrane Central Register of Controlled Trials (CENTRAL), Emcare (Ovid), Embase (Ovid), Scopus, and SciELO will be searched. Primary and gray literature in any language from January 1991 onward will be included. Additional studies will be identified by screening the reference lists of included articles. Study selection and data extraction will be done independently by 2 reviewers. Data will be analyzed descriptively and presented in tables, graphs, and narrative format.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Review registration:<\/jats:title>\n                    <jats:p>OSF https:\/\/osf.io\/e2q49<\/jats:p>\n                  <\/jats:sec>","DOI":"10.11124\/jbies-24-00543","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T08:00:11Z","timestamp":1762848011000},"page":"176-183","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Challenges in the implementation of mass drug administration programs with ivermectin for the control and elimination of onchocerciasis: a scoping review protocol"],"prefix":"10.11124","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2631-084X","authenticated-orcid":false,"given":"Kenny","family":"Geomor","sequence":"first","affiliation":[{"name":"Center for Public Health and Healthcare Research, Master Programme Public Health, Paracelsus Medical University, Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0828-655X","authenticated-orcid":false,"given":"Kathrin","family":"Bogensberger","sequence":"additional","affiliation":[{"name":"Ludwig Boltzmann Institute for Arthritis and Rehabilitation, Vienna, Austria"},{"name":"Center for Physiology, Pathophysiology and Biophysics, Institute for Physiology and Pathophysiology, Paracelsus Medical University, Salzburg, Austria"},{"name":"Gastein Research Institute, Paracelsus Medical University, Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7167-7524","authenticated-orcid":false,"given":"Antje","family":"van der Zee-Neuen","sequence":"additional","affiliation":[{"name":"Ludwig Boltzmann Institute for Arthritis and Rehabilitation, Vienna, Austria"},{"name":"Center for Physiology, Pathophysiology and Biophysics, Institute for Physiology and Pathophysiology, Paracelsus Medical University, Salzburg, Austria"},{"name":"Gastein Research Institute, Paracelsus Medical University, Salzburg, Austria"},{"name":"Center for Public Health and Healthcare Research, Paracelsus Medical University, Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,12,23]]},"reference":[{"issue":"1","key":"R1-20260114","doi-asserted-by":"crossref","first-page":"1-48","DOI":"10.1080\/00034983.1926.11684476","article-title":"The development of onchocerca volvulus in simulium damnosum","volume":"20","author":"Blacklock","year":"1926","journal-title":"Ann Trop Med Parasitol"},{"issue":"41","key":"R3-20260114","first-page":"577-90","article-title":"Elimination of human onchocerciasis: progress report, 2023\u20132024","volume":"99","year":"2024","journal-title":"Wkly Epidemiol Rec"},{"issue":"10159","key":"R4-20260114","first-page":"1789-858","article-title":"GBD 2017 Disease and Injury Incidence and Prevalence Collaborators. 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