{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T14:56:58Z","timestamp":1786460218233,"version":"build-2736575974"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The objective of this review is to evaluate the effectiveness of non-synthetic local drug-delivery agents vs synthetic local drug-delivery agents on periodontal parameters when used as an adjunct to scaling and root planing in adult patients with periodontitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Local delivery of synthetic drugs subgingivally along with conventional scaling and root planing is beneficial to control periodontitis. Over the years, various naturally derived local drug-delivery agents have also been studied for their effect on periodontal parameters when delivered subgingivally in patients with periodontitis. There is growing interest in biocompatible, potentially safer, and more cost-effective alternatives to synthetic agents, but there is also a lack of systematic comparisons between natural and synthetic formulations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Eligibility criteria:<\/jats:title>\n                    <jats:p>Randomized controlled trials, quasi-experimental studies, and non-randomized controlled trials that involve adults (\u226518 years) diagnosed with periodontitis, treated with scaling and root planing and adjunctive local drug-delivery agent will be eligible for inclusion. Eligible studies must compare non-synthetic vs synthetic drug-delivery agents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Searches will be conducted via MEDLINE (EBSCOhost), CINAHL (EBSCOhost), Cochrane CENTRAL, Scopus, Dentistry and Oral Sciences Source, Web of Science Core Collection, and gray literature sources. Articles in any language from database inception onward will be considered. Two reviewers will independently screen the titles and abstracts, and select full texts for inclusion. Critical appraisal of included studies will be done by 2 reviewers independently using standardized JBI checklists. If sufficient data are present, studies will be pooled using meta-analysis, and the results will be discussed narratively. The Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach will be used to assess certainty in the findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Review registration:<\/jats:title>\n                    <jats:p>PROSPERO CRD42023469354<\/jats:p>\n                  <\/jats:sec>","DOI":"10.11124\/jbies-25-00126","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T10:00:30Z","timestamp":1766484030000},"page":"560-570","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Non-synthetic vs synthetic local drug delivery agents for the treatment of periodontitis in adults: a systematic review and meta-analysis protocol"],"prefix":"10.11124","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7516-0066","authenticated-orcid":false,"given":"Pallavi","family":"Menon","sequence":"first","affiliation":[{"name":"Department of Periodontics, Amrita School of Dentistry, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5358-4391","authenticated-orcid":false,"given":"Vineetha","family":"Karuveettil","sequence":"additional","affiliation":[{"name":"Department of Public Health Dentistry, Amrita School of Dentistry, Kochi, Kerala, India"},{"name":"JBI Amrita Centre for Evidence-Based Oral Health, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5194-1818","authenticated-orcid":false,"given":"Shilpa","family":"Ramachandran","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Amrita School of Dentistry, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,3,6]]},"reference":[{"issue":"S20","key":"R1-20260317","doi-asserted-by":"crossref","first-page":"S162","DOI":"10.1111\/jcpe.12946","article-title":"Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions","volume":"45","author":"Papapanou","year":"2018","journal-title":"J Clin Periodontol"},{"issue":"2","key":"R2-20260317","doi-asserted-by":"crossref","first-page":"138-49","DOI":"10.1111\/jcpe.12808","article-title":"Scientific evidence on the links between periodontal diseases and diabetes: Consensus report and guidelines of the joint workshop on periodontal diseases and diabetes by the International Diabetes Federation and the European Federation of Periodontology","volume":"45","author":"Sanz","year":"2018","journal-title":"J Clin Periodontol"},{"issue":"3","key":"R3-20260317","doi-asserted-by":"crossref","first-page":"268-88","DOI":"10.1111\/jcpe.13189","article-title":"Periodontitis and cardiovascular diseases: Consensus report","volume":"47","author":"Sanz","year":"2020","journal-title":"J Clin Periodontol"},{"issue":"s14","key":"R4-20260317","doi-asserted-by":"crossref","first-page":"S164","DOI":"10.1111\/jcpe.12083","article-title":"Working group 3 of the joint EFP\/AAP workshop. 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