{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T15:02:54Z","timestamp":1786460574069,"version":"build-2736575974"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec>\n                    <jats:title>Review question<\/jats:title>\n                    <jats:p>The question of this review is: what is the effectiveness of droxidopa compared to midodrine on standing blood pressure and orthostatic intolerance symptoms in adults with neurogenic orthostatic hypotension?<\/jats:p>\n                  <\/jats:sec>","DOI":"10.11124\/jbisrir-2016-003306","type":"journal-article","created":{"date-parts":[[2017,9,11]],"date-time":"2017-09-11T15:24:25Z","timestamp":1505143465000},"page":"2287-2294","source":"Crossref","is-referenced-by-count":1,"title":["Effectiveness of droxidopa compared to midodrine in standing blood pressure and orthostatic tolerance in adults with neurogenic orthostatic hypotension: a systematic review protocol"],"prefix":"10.11124","volume":"15","author":[{"given":"Kelli","family":"Patrick","sequence":"first","affiliation":[{"name":"School of Nursing, University of Mississippi Medical Center, Jackson, USA"},{"name":"UMMC School of Nursing Evidence Based Practice and Research Team: a Joanna Briggs Institute Affiliated Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Martin","sequence":"additional","affiliation":[{"name":"School of Nursing, University of Mississippi Medical Center, Jackson, USA"},{"name":"UMMC School of Nursing Evidence Based Practice and Research Team: a Joanna Briggs Institute Affiliated Group"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"13","key":"R1-20230825","first-page":"S248","article-title":"Neurogenic Orthostatic Hypotension: Pathophysiology and Diagnosis","volume":"21","author":"Low","year":"2015","journal-title":"Am J Manag Care"},{"issue":"9","key":"R2-20230825","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1007\/s00415-012-6736-7","article-title":"Neurogenic orthostatic hypotension: Pathophysiology, evaluation, and management","volume":"260","author":"Metzler","year":"2013","journal-title":"J Neurol"},{"issue":"7","key":"R3-20230825","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1080\/00325481.2015.1050340","article-title":"Diagnosing and treating neurogenic orthostatic hypotension in primary care","volume":"127","author":"Kuritzky","year":"2015","journal-title":"Postgrad Med"},{"issue":"11","key":"R4-20230825","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11886-014-0542-z","article-title":"New Developments in the Management of Neurogenic Orthostatic Hypotension","volume":"16","author":"Biaggioni","year":"2014","journal-title":"Curr Cardiol Rep"},{"issue":"8","key":"R5-20230825","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1097\/HJH.0000000000000235","article-title":"Association between orthostatic hypotension and cardiovascular risk, cerebrovascular risk, cognitive decline and falls as well as overall mortality: a systematic review and meta-analysis","volume":"32","author":"Angelousi","year":"2014","journal-title":"J Hypertens"},{"key":"R7-20230825","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1161\/CIRCULATIONAHA.108.805887","article-title":"Neurogenic orthostatic hypotension: A pathophysiological approach","volume":"119","author":"Goldstein","year":"2009","journal-title":"Circulation"},{"issue":"11","key":"R8-20230825","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1007\/s11606-013-2520-3","article-title":"Midodrine for orthostatic hypotension: A systematic review and meta-analysis of clinical trials","volume":"28","author":"Parsaik","year":"2013","journal-title":"J Gen Intern Med"},{"issue":"1","key":"R9-20230825","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s10286-007-1005-z","article-title":"L-dihydroxyphenylserine (droxidopa) in the treatment of orthostatic hypotension: The european experience","volume":"18","author":"Mathias","year":"2008","journal-title":"Clin Auton Res"},{"issue":"4","key":"R10-20230825","doi-asserted-by":"crossref","first-page":"751","DOI":"10.3233\/JPD-160860","article-title":"Safety and durability of effect with long-term, open-label droxidopa treatment in patients with symptomatic neurogenic orthostatic hypotension","volume":"6","author":"Isaacson","year":"2016","journal-title":"J Parkinsons Dis"},{"issue":"1","key":"R11-20230825","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s10286-007-1002-2","article-title":"L-dihydroxyphenylserine (droxidopa): A new therapy for neurogenic orthostatic hypotension: the US experience","volume":"18","author":"Kaufmann","year":"2008","journal-title":"Clin Auton Res"},{"issue":"11","key":"R12-20230825","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1185\/03007995.2015.1087988","article-title":"Neurogenic orthostatic hypotension: Roles of norepinephrine deficiency and its causes, its treatment, and future research directions","volume":"31","author":"Loavenbruck","year":"2015","journal-title":"Curr Med Res Opin"},{"issue":"8","key":"R13-20230825","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1586\/14779072.2015.1057504","article-title":"Droxidopa in neurogenic orthostatic hypotension","volume":"13","author":"Kaufmann","year":"2015","journal-title":"Expert Rev Cardiovasc Ther"},{"issue":"2","key":"R14-20230825","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s40265-014-0342-1","article-title":"Droxidopa: A review of its use in symptomatic neurogenic orthostatic hypotension","volume":"75","author":"Keating","year":"2015","journal-title":"Drugs"},{"key":"R15-20230825","doi-asserted-by":"crossref","first-page":"915","DOI":"10.2147\/TCRM.S68439","article-title":"Neurogenic orthostatic hypotension: management update and role of droxidopa","volume":"11","author":"Sharma Vijayan","year":"2015","journal-title":"Ther Clin Risk Manag"},{"issue":"12","key":"R16-20230825","first-page":"S258","article-title":"Managed Care Approach to the Treatment of Neurogenic Orthostatic Hypotension","volume":"21","author":"Isaacson","year":"2015","journal-title":"Am J Manag Care"},{"issue":"1","key":"R18-20230825","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/0002-9343(93)90230-M","article-title":"Neurogenic orthostatic hypotension: a double-blind, placebo-controlled study with midodrine","volume":"95","author":"Jankovic","year":"1993","journal-title":"Am J Med"},{"issue":"10","key":"R19-20230825","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1097\/HJH.0000000000001043","article-title":"Droxidopa for orthostatic hypotension: A systematic review and meta-analysis","volume":"34","author":"Strassheim","year":"2016","journal-title":"J Hypertens"},{"issue":"1","key":"R20-20230825","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s10286-007-1003-1","article-title":"Current pharmacologic treatment for orthostatic hypotension","volume":"18","author":"Freeman","year":"2008","journal-title":"Clin Auton Res"},{"issue":"3","key":"R22-20230825","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1097\/XEB.0000000000000065","article-title":"Fixed or random effects meta-analysis? Common methodological issues in systematic review of effectiveness","volume":"13","author":"Tufanaru","year":"2015","journal-title":"Int J Evid Based Healthc"}],"container-title":["JBI Database of Systematic Reviews and Implementation Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01938924-201709000-00011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T12:57:16Z","timestamp":1786453036000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01938924-201709000-00011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":19,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.11124\/jbisrir-2016-003306","relation":{},"ISSN":["2202-4433"],"issn-type":[{"value":"2202-4433","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9]]}}}