{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T15:04:24Z","timestamp":1786460664298,"version":"build-2736575974"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The objective of this review was to identify associations between premorbid neuropsychological conditions and pediatric mild traumatic brain injury\/concussion recovery time and symptom severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>There is a lack of evidence-based clinical guidelines for the care of children with a premorbid neuropsychological condition who have sustained a mild traumatic brain injury, also known as concussion. This necessitates inquiry for any associations that may exist, which may contribute to an enhanced understanding of injury recovery patterns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Inclusion criteria:<\/jats:title>\n                    <jats:p>Participants included children ages six through 18 years with any diagnosed or self-reported premorbid neuropsychological condition(s) and mild traumatic brain injury\/concussion. Participants with concomitant intracranial or extra-axial head injury found on diagnostic imaging were excluded. Outcomes for this review included recovery time or symptom(s) severity post-concussion. Studies considered for review were analytical observational studies, including retrospective, prospective, cross-sectional or longitudinal cohort studies or case-control studies, as well as descriptive observational study designs, including case series, individual case reports and descriptive cross-sectional studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      A comprehensive search was undertaken in January 2018 for both published and unpublished studies utilizing an\n                      <jats:italic toggle=\"yes\">a priori<\/jats:italic>\n                      protocol. Major databases searched included CINAHL, Embase, PubMed, Psychology and Behavioral Sciences Collection and PsycINFO. Other sources searched for unpublished and gray literature included the Cochrane Central Register of Controlled Trials, ClinicalTrials.gov, Google Scholar, ProQuest Dissertations and Theses Global: Sciences and Engineering Collection and MedNar. Additional searches of government websites and reports targeting healthcare or sports-related concussions included Australian Sports Commission, Canadian Institutes for Health Research, the National Health Service of the United Kingdom, the U.S. Department of Health and Human Services: Agency for Healthcare Research and Quality, and the U.S. Department of Health and Human Services: Centers for Disease Control and Prevention. Critical appraisal and data extraction were completed by two independent reviewers. Validation of methodologic quality was performed utilizing standardized tools from the Joanna Briggs Institute, and any disputes were resolved through discussion. Due to significant heterogeneity among studies, a meta-analysis could not be conducted. Therefore, extracted data are reported in a narrative synthesis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 12 studies (one analytical cross-sectional, two case-control and nine cohort) with 2,973 participants met inclusion criteria. Results of the findings among premorbid conditions varied. However, statistically significant associations with prolonged recovery or increased symptom severity were identified in children with pre-concussion histories of learning disabilities or poor academic achievement; anxiety, depression, mood disorders or other psychiatric illnesses; prior head injuries; somatization (in females); sleep disorders (in males); and the presence of multiple neuropsychological conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Due to heterogeneity among studies and limitations of the review, findings suggest that clinicians providing post-concussive care may consider the presence of premorbid neuropsychological conditions, specifically learning disabilities or poor academic achievement; anxiety, depression, mood disorders or other psychiatric illnesses; prior head injuries; somatization; sleep disorders; or the presence of multiple neuropsychological conditions as potential contributors to prolonged recovery times or increased symptom severity in children and adolescents with mild traumatic brain injuries.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.11124\/jbisrir-2017-004008","type":"journal-article","created":{"date-parts":[[2019,7,12]],"date-time":"2019-07-12T16:55:13Z","timestamp":1562950513000},"page":"1464-1493","source":"Crossref","is-referenced-by-count":20,"title":["Association between premorbid neuropsychological conditions and pediatric mild traumatic brain injury\/concussion recovery time and symptom severity: a systematic review"],"prefix":"10.11124","volume":"17","author":[{"given":"Michelle Borzik","family":"Goreth","sequence":"first","affiliation":[{"name":"School of Nursing, University of Mississippi Medical Center, Jackson, USA"},{"name":"Mississippi Centre for Evidence Based Practice: a Joanna Briggs Institute Centre of Excellence"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Palokas","sequence":"additional","affiliation":[{"name":"School of Nursing, University of Mississippi Medical Center, Jackson, USA"},{"name":"Mississippi Centre for Evidence Based Practice: a Joanna Briggs Institute Centre of Excellence"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"(4)","key":"R2-20230825","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nrneurol.2013.22","article-title":"Changing patterns in the epidemiology of traumatic brain injury","volume":"9","author":"Roozenbeek","year":"2013","journal-title":"Nat Rev Neurol"},{"issue":"(6)","key":"R3-20230825","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1017\/cjn.2016.290","article-title":"The international incidence of traumatic brain injury: a systematic review and meta-analysis","volume":"43","author":"Nguyen","year":"2016","journal-title":"Can J Neurol Sci"},{"issue":"(6)","key":"R6-20230825","first-page":"267","article-title":"Mild traumatic brain injury in children","volume":"39","author":"Mason","year":"2013","journal-title":"Pediatr Nurs"},{"issue":"(6)","key":"R7-20230825","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1017\/S1355617710000986","article-title":"Mild traumatic brain injury and postconcussive symptoms in children and adolescents","volume":"16","author":"Yeates","year":"2010","journal-title":"Int Neuropsychol Soc"},{"issue":"(9)","key":"R8-20230825","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1001\/jamapediatrics.2014.361","article-title":"Isolated loss of consciousness in children with minor blunt head trauma","volume":"168","author":"Lee","year":"2014","journal-title":"JAMA Pediatr"},{"issue":"(17)","key":"R9-20230825","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1089\/neu.2015.4292","article-title":"Health-related quality of life after pediatric mild traumatic brain injury\/concussion: a systematic review","volume":"33","author":"Fineblit","year":"2016","journal-title":"J Neurotrauma"},{"issue":"(3)","key":"R10-20230825","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1001\/archpedi.160.3.252","article-title":"Health-related quality of life during the first year after traumatic brain injury","volume":"160","author":"McCarthy","year":"2006","journal-title":"Arch Pediatr Adolesc Med"},{"issue":"(3)","key":"R11-20230825","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1001\/2013.jamapediatrics.216","article-title":"Prognosticators of persistent symptoms following pediatric concussion: a systematic review","volume":"167","author":"Zemek","year":"2013","journal-title":"JAMA Pediatr"},{"issue":"(5)","key":"R12-20230825","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1080\/13854040701543700","article-title":"Management of pediatric mild traumatic brain injury: a neuropsychological review from injury: review from injury through recovery","volume":"22","author":"Kirkwood","year":"2008","journal-title":"Clin Neuropsychol"},{"issue":"(7)","key":"R13-20230825","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1093\/jpepsy\/jsr087","article-title":"Quality of life in pediatric mild traumatic brain injury and its relationship to postconcussive symptoms","volume":"37","author":"Moran","year":"2012","journal-title":"J Pediatr Psychol"},{"issue":"(150)","key":"R14-20230825","first-page":"1","article-title":"Injury-related emergency department visits by children and adolescents: United States, 2009\u20132010","author":"Albert","year":"2014","journal-title":"NCHS Data Brief"},{"issue":"(2)","key":"R15-20230825","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1542\/peds.2005-2588","article-title":"Incidence of pediatric traumatic brain injury and associated hospital resource utilization in the United States","volume":"118","author":"Schneier","year":"2006","journal-title":"Pediatrics"},{"issue":"(11)","key":"R16-20230825","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1136\/bjsports-2017-097699","article-title":"Consensus statement on concussion in sport\u2014the 5th international conference on concussion in sport held in Berlin, October 2016","volume":"51","author":"McCrory","year":"2017","journal-title":"Br J Sports Med"},{"issue":"(3)","key":"R18-20230825","first-page":"594","article-title":"The association of premorbid neuropsychological conditions with pediatric mild traumatic brain injury\/concussion recovery time and symptom severity: a systematic review protocol","volume":"16","author":"Goreth","year":"2018","journal-title":"JBI Database System Rev Implement Rep"},{"issue":"(4)","key":"R19-20230825","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/JSM.0000000000000151","article-title":"Relationship of attention deficit hyperactivity disorder and postconcussion recovery in youth athletes","volume":"25","author":"Mautner","year":"2015","journal-title":"Clin J Sport Med"},{"issue":"(3)","key":"R20-20230825","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1097\/XEB.0000000000000064","article-title":"Conducting systematic reviews of association (etiology): The Joanna Briggs Institute's Approach","volume":"13","author":"Moola","year":"2015","journal-title":"Int J Evid Based Healthc"},{"issue":"(7)","key":"R21-20230825","doi-asserted-by":"crossref","first-page":"e1000097","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLoS Med"},{"issue":"(6)","key":"R23-20230825","doi-asserted-by":"crossref","first-page":"589","DOI":"10.3171\/2014.10.PEDS14356","article-title":"Predictors of postconcussion syndrome after sports-related concussion in young athletes: a matched case-control study","volume":"15","author":"Morgan","year":"2015","journal-title":"J Neurosurg Pediatr"},{"issue":"(8)","key":"R25-20230825","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1089\/neu.2015.4082","article-title":"Additional post-concussion impact exposure may affect recovery in adolescent athletes","volume":"33","author":"Terwilliger","year":"2016","journal-title":"J Neurotrauma"},{"issue":"(10)","key":"R26-20230825","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1017\/S1355617716000916","article-title":"Applying an evidence-based assessment model to identify students at risk for perceived academic problems following concussion","volume":"22","author":"Ransom","year":"2016","journal-title":"J Int Neuropsychol Soc"},{"key":"R27-20230825","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jpeds.2016.03.020","article-title":"History of somatization is associated with prolonged recovery from concussion","volume":"174","author":"Root","year":"2016","journal-title":"J Pediatr"},{"issue":"(14)","key":"R28-20230825","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1089\/neu.2016.4842","article-title":"Trajectories and risk factors for post-traumatic stress symptoms following pediatric concussion","volume":"34","author":"Truss","year":"2017","journal-title":"J Neurotrauma"},{"issue":"(2)","key":"R29-20230825","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1017\/S135561771200104X","article-title":"Predictors of 1-month and 1-year neurocognitive functioning from the UCLA longitudinal mild, uncomplicated, pediatric traumatic brain injury study","volume":"19","author":"Babikian","year":"2013","journal-title":"J Int Neuropsychol Soc"},{"issue":"(9)","key":"R30-20230825","doi-asserted-by":"crossref","first-page":"e426","DOI":"10.1111\/apa.13486","article-title":"Initial somatic symptoms are associated with prolonged symptom duration following concussion in adolescents","volume":"105","author":"Howell","year":"2016","journal-title":"Acta Paediatrica"},{"issue":"(1)","key":"R31-20230825","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/02699052.2012.722251","article-title":"Risk factors for concussive symptoms 1 week or longer in high school athletes","volume":"27","author":"Chrisman","year":"2013","journal-title":"Brain Inj"}],"container-title":["JBI Database of Systematic Reviews and Implementation Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01938924-201907000-00014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T13:00:51Z","timestamp":1786453251000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01938924-201907000-00014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":25,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.11124\/jbisrir-2017-004008","relation":{},"ISSN":["2202-4433"],"issn-type":[{"value":"2202-4433","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7]]}}}