{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T07:14:01Z","timestamp":1763018041169,"version":"3.45.0"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The objective of this review is to evaluate the effect of prior aspiration vs no aspiration during intramuscular injection on the occurrence of adverse effects in adult patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Aspiration is a procedure conducted prior to the administration of intramuscular medications that aims to ensure that the needle tip is inserted in the proper place. Although aspiration is a common procedure, questions have been raised about adverse effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Inclusion criteria:<\/jats:title>\n                    <jats:p>This review will consider experimental and observational studies that include or evaluate the occurrence of any adverse effects following intramuscular injection, either with or without prior syringe aspiration, in adult patients. Adverse effects will include local pain, induration, puncture of blood vessels, decreased drug effect, hematoma, or abscess. The review will exclude studies on venipuncture, aspiration biopsies, or other invasive punctures of a diagnostic nature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This review will be conducted in accordance with the JBI methodology for systematic reviews of effectiveness. Databases to be searched will include PubMed, Embase, CINAHL, Scopus, LILACS, and Web of Science Core Collection, as well as sources of unpublished\/gray literature, with no date or language limitations. Two independent reviewers will conduct study selection, critical appraisal, and data extraction. Studies will, where possible, be pooled in statistical meta-analysis. The grading of the certainty of evidence will be determined using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Registration number:<\/jats:title>\n                    <jats:p>PROSPERO CRD42021270432<\/jats:p>\n                  <\/jats:sec>","DOI":"10.11124\/jbies-23-00225","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T04:07:48Z","timestamp":1736222868000},"page":"394-400","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Effect of aspiration during intramuscular injection on the occurrence of adverse effects in adults: a systematic review protocol"],"prefix":"10.11124","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6570-4645","authenticated-orcid":false,"given":"Marluce Rodrigues","family":"Godinho","sequence":"first","affiliation":[{"name":"Faculty of Nursing, Universidade Federal of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2065-5998","authenticated-orcid":false,"given":"F\u00e1bio da Costa","family":"Carbogim","sequence":"additional","affiliation":[{"name":"Faculty of Nursing, Universidade Federal of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil"},{"name":"Brazilian Centre of Evidence-based Healthcare: A JBI Centre of Excellence, S\u00e3o Paulo, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7526-900X","authenticated-orcid":false,"given":"Ang\u00e9lica da Concei\u00e7\u00e3o Oliveira","family":"Coelho","sequence":"additional","affiliation":[{"name":"Faculty of Nursing, Universidade Federal of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3924-1587","authenticated-orcid":false,"given":"Gabriela Do Nascimento Martins de","family":"Araujo","sequence":"additional","affiliation":[{"name":"Faculty of Nursing, Universidade Federal of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6859-4333","authenticated-orcid":false,"given":"Amanda Damasceno de","family":"Souza","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Information and Communication Technology and Knowledge Management (PPGTICGC) - University FUMEC, Belo Horizonte, Minas Gerais, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9053-8749","authenticated-orcid":false,"given":"Helen Vaz da Silva","family":"Gomes","sequence":"additional","affiliation":[{"name":"Faculty of Nursing, Universidade Federal of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2866-8830","authenticated-orcid":false,"given":"Alice Maria Das Gra\u00e7as de","family":"Sousa","sequence":"additional","affiliation":[{"name":"Faculty of Nursing, Universidade Federal of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9256-3702","authenticated-orcid":false,"given":"Herlander Jesus Borges Tom\u00e1s","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"CINTESIS - Center for Health Technology and Services Research, University of Porto, Faculty of Medicine, Porto, Portugal"},{"name":"Faculty of Science and Technology - University of Cabo Verde, Praia, Cabo Verde"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8423-9147","authenticated-orcid":false,"given":"Kelli Borges Dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Faculty of Nursing, Universidade Federal of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil"},{"name":"Brazilian Centre of Evidence-based Healthcare: A JBI Centre of Excellence, S\u00e3o Paulo, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4811-6753","authenticated-orcid":false,"given":"Rui Pedro Gomes","family":"Pereira","sequence":"additional","affiliation":[{"name":"School of Nursing of the University of Minho, Health Sciences Research Unit: Nursing (UICISA: E), Nursing School of Coimbra (Esenfc), Coimbra, Portugal"}]}],"member":"276","published-online":{"date-parts":[[2025,2,12]]},"reference":[{"issue":"6","key":"R2-20251113","doi-asserted-by":"crossref","first-page":"350","DOI":"10.12968\/bjon.2021.30.6.350","article-title":"COVID-19 vaccination: intramuscular injection technique","volume":"30","author":"Gordon","year":"2021","journal-title":"Br J Nurs"},{"key":"R3-20251113","doi-asserted-by":"crossref","first-page":"157","DOI":"10.12688\/f1000research.1113.1","article-title":"Aspiration in injections: should we continue or abandon the practice?","volume":"3","author":"Sepah","year":"2014","journal-title":"F1000Res"},{"issue":"1","key":"R4-20251113","doi-asserted-by":"crossref","first-page":"228","DOI":"10.9789\/2175-5361.2019.v11i1.228-236","article-title":"(Re)discussing 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Common methodological issues in systematic reviews of effectiveness","volume":"13","author":"Tufanaru","year":"2015","journal-title":"Int J Evid Based Healthc"}],"container-title":["JBI Evidence Synthesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.11124\/JBIES-23-00225","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T07:00:11Z","timestamp":1763017211000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.11124\/JBIES-23-00225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.11124\/jbies-23-00225","relation":{},"ISSN":["2689-8381"],"issn-type":[{"type":"electronic","value":"2689-8381"}],"subject":[],"published":{"date-parts":[[2025,2]]}}}