{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T02:27:07Z","timestamp":1787970427808,"version":"build-2784847793"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,6,8]],"date-time":"2015-06-08T00:00:00Z","timestamp":1433721600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Department of Physiology and the Otago School of Medical Sciences - University of Otago"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec><jats:title>New Findings<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item>\n<jats:p><jats:bold>What is the central question of this study?<\/jats:bold><\/jats:p>\n<jats:p>Can bilateral renal denervation, an effective antihypertensive treatment in clinical and experimental studies, improve cardiac \u03b2\u2010adrenoceptor responsiveness in a diabetic model with underlying hypertension?<\/jats:p>\n<\/jats:list-item>\n<jats:list-item>\n<jats:p><jats:bold>What is the main finding and its importance?<\/jats:bold><\/jats:p>\n<jats:p>Bilateral renal denervation did not affect \u03b2\u2010adrenergic responsiveness in the diabetic hypertensive rat heart, but denervation reduced the hypertension\u2010induced concentric hypertrophic remodelling. This suggests that the positive haemodynamic changes induced by renal denervation are most likely to reflect an attenuation of sympathetic effects on the systemic vasculature and\/or the renal function rather than direct sympathetic modulation of the heart.<\/jats:p>\n<\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>Bilateral renal denervation (BRD) has been shown to normalise blood pressure in clinical and experimental studies of hypertension by reducing systemic sympathetic output. This study determined the effect of BRD on cardiac \u03b2\u2010adrenoceptor (AR) responsiveness in a diabetic model with underlying hypertension using the transgenic (mRen\u20102)27 rats. Bilateral renal denervation or sham surgeries were conducted repeatedly at 3, 6 and 9\u00a0weeks in Ren\u20102 rats with or without streptozotocin (STZ)\u2010induced diabetes (4\u00a0\u00d7\u00a0<jats:italic>n<\/jats:italic>\u00a0=\u00a07); Sprague\u2013Dawley rats (<jats:italic>n<\/jats:italic>\u00a0=\u00a06) served as control animals. Cardiac function was determined in isolated hearts at 18\u00a0weeks of age. Normalised left ventricular developed pressure and relaxation was recorded in response to incremental concentrations of the \u03b2\u2010AR agonist isoprenaline (from 10\u221210 to 10\u22127\u00a0m) or the \u03b2<jats:sub>3<\/jats:sub>\u2010AR agonist BRL37344 (from 10<jats:sup>\u221213<\/jats:sup> to 10<jats:sup>\u22126\u00a0<\/jats:sup><jats:sc>m<\/jats:sc>). Expression levels of \u03b2<jats:sub>1<\/jats:sub>\u2010AR were determined by Western blot. Both inotropic and lusitropic \u03b2\u2010AR responsiveness was reduced in the hypertensive diabetic hearts, but these responses were unaltered after BRD. Expression levels of \u03b2<jats:sub>1<\/jats:sub>\u2010AR were increased after BRD (Sham, 0.85\u00a0\u00b1\u00a00.11\u00a0<jats:italic>versus<\/jats:italic> 1.01\u00a0\u00b1\u00a00.05\u00a0a.u.; BRD, 1.45\u00a0\u00b1\u00a00.11\u00a0<jats:italic>versus<\/jats:italic> 1.46\u00a0\u00b1\u00a00.07\u00a0a.u.; Ren\u20102\u00a0<jats:italic>versus<\/jats:italic> Ren\u20102 STZ, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05\u00a0<jats:italic>versus<\/jats:italic> Sham). No effect of \u03b2<jats:sub>3<\/jats:sub>\u2010AR agonist stimulation with BRL37344 was observed. Interestingly, BRD increased left ventricular diastolic volume in both the Ren\u20102 and the Ren\u20102 STZ groups. Bilateral renal denervation did not restore the attenuated cardiac \u03b2\u2010AR responsiveness in the diabetic hypertensive rats, but it reduced the extent of hypertension\u2010induced concentric hypertrophic remodelling. Thus, the haemodynamic protection offered by renal denervation appears to reflect an attenuated sympathetic innervation of the systemic vasculature and\/or kidney rather than a direct cardiac effect.<\/jats:p><\/jats:sec>","DOI":"10.1113\/ep085021","type":"journal-article","created":{"date-parts":[[2015,4,16]],"date-time":"2015-04-16T09:23:00Z","timestamp":1429176180000},"page":"628-639","source":"Crossref","is-referenced-by-count":10,"title":["Chronic bilateral renal denervation reduces cardiac hypertrophic remodelling but not \u03b2\u2010adrenergic responsiveness in hypertensive type 1 diabetic rats"],"prefix":"10.1113","volume":"100","author":[{"given":"H. P. Aye","family":"Thaung","sequence":"first","affiliation":[{"name":"Department of Physiology \u2013 HeartOtago, Otago School of Medical Sciences University of Otago  Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yimin","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Otago School of Medical Sciences University of Otago  Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol T.","family":"Bussey","sequence":"additional","affiliation":[{"name":"Department of Physiology \u2013 HeartOtago, Otago School of Medical Sciences University of Otago  Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian","family":"Hughes","sequence":"additional","affiliation":[{"name":"Department of Physiology \u2013 HeartOtago, Otago School of Medical Sciences University of Otago  Dunedin New 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