{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:10:59Z","timestamp":1790964659600,"version":"4.1.0"},"reference-count":56,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,2,29]],"date-time":"2016-02-29T00:00:00Z","timestamp":1456704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec>\n                    <jats:title>New Findings<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>\n                            <jats:bold>What is the central question of this study?<\/jats:bold>\n                          <\/jats:p>\n                          <jats:p>Head\u2010to\u2010head comparison of the therapeutic efficacy among commercial iron chelators and a dual T\u2010 (TTCC) and L\u2010type calcium channel (LTCC) blocker on cardiac function, mitochondrial function and the protein expression of cardiac iron transporters in thalassaemic mice in iron\u2010overloaded conditions has not been assessed.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            <jats:bold>What is the main finding and its importance?<\/jats:bold>\n                          <\/jats:p>\n                          <jats:p>The dual TTCC and LTCC blocker efonidipine could provide broad beneficial effects in the heart, liver, plasma and mitochondria in both wild\u2010type and thalassaemic mice in iron\u2010overloaded conditions. Its beneficial effects are of the same degree as the three commercial iron chelators currently used clinically. It is possible that efonidipine could be an alternative choice in patients unable to take iron chelators for the treatment of iron\u2010overload conditions.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Iron chelation therapy is a standard treatment in thalassaemia patients; however, its poor cardioprotective efficacy and serious side\u2010effects are a cause for concern. Previous studies have shown that treatment with L\u2010type calcium channel (LTCC) blockers or dual T\u2010type calcium channel (TTCC) and LTCC blockers decreases cardiac iron and improves cardiac dysfunction in an iron\u2010overloaded rodent model. Currently, the head\u2010to\u2010head comparison of therapeutic efficacy among commercial iron chelators, a dual TTCC and LTCC blocker and an LTCC blocker on cardiac function, mitochondrial function and the protein expression of cardiac iron transporters in thalassaemic mice in an iron\u2010overloaded state has never been investigated. An iron\u2010overloaded state was induced in \u03b2\u2010thalassaemic and wild\u2010type mice. Cardiac iron overload was induced to a greater extent than in a previous study by feeding the mice with an iron\u2010enriched diet for 4\u00a0months. Then, an LTCC blocker (amlodipine) or a dual TTCC and LTCC blocker (efonidipine) or one of the commercial iron chelators (deferoxamine, deferasirox or deferiprone) was administered for 1\u00a0month with continuous iron feeding. All treatments reduced cardiac iron deposition and improved mitochondrial and cardiac dysfunction in both types of mice. Only efonidipine and the iron chelators reduced liver iron accumulation, liver malondialdehyde and plasma malondialdehyde in these mice. Although all pharmacological interventions reduced cardiac iron deposition, they did not alter the protein expression levels of cardiac iron transporter. These findings indicated that efonidipine provided all benefits to the same degree as the three commercial iron chelators. These findings indicate that a dual TTCC and LTCC blocker could be beneficial for treatment of an iron\u2010overloaded state.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1113\/ep085517","type":"journal-article","created":{"date-parts":[[2016,1,29]],"date-time":"2016-01-29T09:54:52Z","timestamp":1454061292000},"page":"521-539","source":"Crossref","is-referenced-by-count":45,"title":["Dual T\u2010type and L\u2010type calcium channel blocker exerts beneficial effects in attenuating cardiovascular dysfunction in iron\u2010overloaded thalassaemic mice"],"prefix":"10.1113","volume":"101","author":[{"given":"Sirinart","family":"Kumfu","sequence":"first","affiliation":[{"name":"Cardiac Electrophysiology Research and Training Center, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"},{"name":"Cardiac Electrophysiology Unit, Department of Physiology, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"},{"name":"Center of Excellence in Cardiac Electrophysiology 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