{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T04:01:07Z","timestamp":1768449667833,"version":"3.49.0"},"reference-count":49,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,7,17]],"date-time":"2016-07-17T00:00:00Z","timestamp":1468713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:sec><jats:title>New Findings<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item>\n<jats:p><jats:bold>What is the central question of this study<\/jats:bold>?<\/jats:p>\n<jats:p>We investigated the effects of physical training on phenotypic (fibre\u2010type content) and myogenic features (MyoD and myogenin expression) in skeletal muscle during the transition from cardiac hypertrophy to heart failure.<\/jats:p>\n<\/jats:list-item>\n<jats:list-item>\n<jats:p><jats:bold>What is the main finding and its importance<\/jats:bold>?<\/jats:p>\n<jats:p>We provide new insight into skeletal muscle adaptations by showing that physical training increases the type I fibre content during the transition from cardiac hypertrophy to heart failure, without altering MyoD and myogenin expression. These results have important clinical implications for patients with heart failure, because this population has reduced muscle oxidative capacity.<\/jats:p>\n<\/jats:list-item><\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>The purpose of this study was to investigate the effects of physical training (PT) on phenotypic features (fibre\u2010type content) and myogenic regulatory factors (MyoD and myogenin) in rat skeletal muscle during the transition from cardiac hypertrophy to heart failure. We used the model of ascending aortic stenosis (AS) to induce heart failure in male Wistar rats. Sham\u2010operated animals were used as age\u2010matched controls. At 18\u00a0weeks after surgery, rats with ventricular dysfunction were randomized into the following four groups: sham\u2010operated, untrained (Sham\u2010U; <jats:italic>n<\/jats:italic>\u00a0=\u00a08); sham\u2010operated, trained (Sham\u2010T; <jats:italic>n<\/jats:italic>\u00a0=\u00a06); aortic stenosis, untrained (AS\u2010U; <jats:italic>n<\/jats:italic>\u00a0=\u00a06); and aortic stenosis, trained (AS\u2010T; <jats:italic>n<\/jats:italic>\u00a0=\u00a08). The AS\u2010T and Sham\u2010T groups were submitted to a 10\u00a0week aerobic PT programme, while the AS\u2010U and Sham\u2010U groups remained untrained for the same period of time. After the PT programme, the animals were killed and the soleus muscles collected for phenotypic and molecular analyses. Physical training promoted type IIa\u2010to\u2010I fibre conversion in the trained groups (Sham\u2010T and AS\u2010T) compared with the untrained groups (Sham\u2010U and AS\u2010U). No significant (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05) differences were found in type I or IIa fibre content in the AS\u2010U group compared with the Sham\u2010U group. Additionally, there were no significant (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05) differences in the myogenic regulatory factors <jats:italic>MyoD<\/jats:italic> and <jats:italic>myogenin<\/jats:italic> (gene and protein) expression between the groups. Therefore, our results indicate that PT may be a suitable strategy to improve the oxidative phenotype in skeletal muscle during the transition from cardiac hypertrophy to heart failure, without altering <jats:italic>MyoD<\/jats:italic> and <jats:italic>myogenin<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1113\/ep085552","type":"journal-article","created":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T22:05:59Z","timestamp":1464127559000},"page":"1075-1085","source":"Crossref","is-referenced-by-count":7,"title":["Training improves the oxidative phenotype of muscle during the transition from cardiac hypertrophy to heart failure without altering MyoD and myogenin"],"prefix":"10.1113","volume":"101","author":[{"given":"Francis Lopes","family":"Pacagnelli","sequence":"first","affiliation":[{"name":"Department of Physiotherapy UNOESTE  Presidente Prudente S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreo 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