{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:01:58Z","timestamp":1785420118841,"version":"3.56.0"},"reference-count":60,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,10,5]],"date-time":"2016-10-05T00:00:00Z","timestamp":1475625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007772","name":"Agir Pour les Maladies Chroniques","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007772","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>New Findings<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p><jats:bold>What is the central question of this study?<\/jats:bold><\/jats:p>\n<jats:p>This study addresses the relative impact of obesity and intermittent hypoxia in the pathophysiological process of obstructive sleep apnoea by investigating the metabolic, inflammatory and cardiovascular consequences of intermittent hypoxia in lean and obese Zucker rats.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p><jats:bold>What is the main finding and its importance?<\/jats:bold><\/jats:p>\n<jats:p>We found that obesity and intermittent hypoxia have mainly distinct consequences on the investigated inflammatory and cardiometabolic parameters in Zucker rats. This suggests that, for a given severity of sleep apnea, the association of obesity and obstructive sleep apnoea may not necessarily be deleterious.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>Obstructive sleep apnoea is associated with obesity with a high prevalence, and both co\u2010morbidities are independent cardiovascular risk factors. Intermittent hypoxia (IH) is thought to be the main factor responsible for the obstructive sleep apnoea\u2010related cardiometabolic alterations. The aim of this study was to assess the respective impact of obesity and IH on the inflammatory and cardiometabolic state in rats. Lean and obese Zucker rats were exposed to normoxia or chronic IH, and we assessed metabolic and inflammatory parameters, such as plasma lipids and glucose, serum leptin and adiponectin, liver cytokines, nuclear factor\u2010\u03baB activity and cardiac endothelin\u20101 levels. Myocardial infarct size was also evaluated following <jats:italic>in vitro<\/jats:italic> ischaemia\u2013reperfusion. Circulating lipids, insulin, homeostasis model assessment of insulin resistance (HOMA\u2010IR), leptin and adiponectin levels were higher in obese <jats:italic>versus<\/jats:italic> lean rats. Chronic IH did not have a significant impact on metabolic parameters in lean rats. In obese rats, IH increased glycaemia and HOMA\u2010IR. Liver interleukin\u20106 and tumour necrosis factor\u2010\u03b1 levels were elevated in lean rats exposed to IH; obesity prevented the increase in interleukin\u20106 but not in tumour necrosis factor\u2010\u03b1. Finally, IH exposure enhanced myocardial sensitivity to infarction in both lean and obese rats and increased cardiac endothelin\u20101 in lean but not obese rats. In conclusion, this study shows that the dyslipidaemia and insulin resistance induced by obesity of genetic origin does not enhance the deleterious cardiovascular response to IH and may even partly protect against IH\u2010induced inflammation.<\/jats:p><\/jats:sec>","DOI":"10.1113\/ep085783","type":"journal-article","created":{"date-parts":[[2016,9,12]],"date-time":"2016-09-12T10:22:53Z","timestamp":1473675773000},"page":"1432-1442","source":"Crossref","is-referenced-by-count":20,"title":["Intermittent hypoxia in obese Zucker rats: cardiometabolic and inflammatory effects"],"prefix":"10.1113","volume":"101","author":[{"given":"Anne","family":"Brian\u00e7on\u2010Marjollet","sequence":"first","affiliation":[{"name":"Univ Grenoble Alpes  HP2, F\u201038041 Grenoble Cedex France"},{"name":"INSERM U1042  F\u201038041 Grenoble Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Monneret","sequence":"additional","affiliation":[{"name":"Univ Grenoble 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