{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T18:21:28Z","timestamp":1769970088396,"version":"3.49.0"},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,10,31]],"date-time":"2016-10-31T00:00:00Z","timestamp":1477872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81460112"],"award-info":[{"award-number":["81460112"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31440053"],"award-info":[{"award-number":["31440053"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>New Findings<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p><jats:bold>What is the central question of this study?<\/jats:bold><\/jats:p>\n<jats:p>Duodenal ulcer is a common disease. A sex\u2010based difference in the incidence of duodenal ulcer has long been observed clinically, but the cause is unclear.<\/jats:p>\n<\/jats:list-item>\n<jats:list-item><jats:p><jats:bold>What is the main finding and its importance?<\/jats:bold><\/jats:p>\n<jats:p>Duodenal mucosal bicarbonate secretion is the most important protective factor in duodenal mucosa against acid\u2010induced damage. The cystic fibrosis transmembrane conductance regulator (CFTR) and the solute\u2010linked carrier 26 gene family A6 (SLC26A6) are two key bicarbonate transport proteins that mediate duodenal mucosal bicarbonate secretion. We demonstrate that endogenous oestrogen upregulates the expression levels and functional activities of duodenal mucosal CFTR and SLC26A6, which contributes to the sex difference in the prevalence of duodenal ulcer.<\/jats:p>\n<\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>The incidence of duodenal ulcer is markedly lower in women than men, but the cause of the sex difference is not clear. The cystic fibrosis transmembrane conductance regulator (CFTR) and the solute\u2010linked carrier 26 gene family A6 (SLC26A6) are two key bicarbonate transport proteins that mediate duodenal mucosal bicarbonate secretion, which is an important protective factor against acid\u2010induced duodenal injury. The aim of this study was to investigate the effect of oestrogen on the expressions and functional activities of CFTR and SLC26A6 in duodenal mucosa. We found that the expression levels of duodenal CFTR and SLC26A6 were markedly higher in young (20\u2010 to 30\u2010year\u2010old) women than in young men and old (60\u2010 to 70\u2010year\u2010old) women and men. The expression levels of CFTR and SLC26A6 in young women were markedly higher in preovulatory phases than in premenstrual phases, which was consistent with the changes of serum estradiol concentrations. Further results showed that duodenal CFTR and SLC26A6 expression levels in female mice were markedly decreased after ovariectomy, and supplementation with estradiol reversed the changes in CFTR and SLC26A6. 17\u03b2\u2010Estradiol increased <jats:italic>CFTR<\/jats:italic> and <jats:italic>SLC26A6<\/jats:italic> expression levels of human duodenocytes in experiments <jats:italic>in vitro<\/jats:italic>. Functional experiments showed that basal and forskolin\u2010 and prostaglandin E<jats:sub>2<\/jats:sub>\u2010stimulated duodenal bicarbonate secretion in ovariectomized mice was markedly decreased and, likewise, supplementation with 17\u03b2\u2010estradiol reversed the changes. In conclusion, endogenous oestrogen upregulates the expressions and functional activities of CFTR and SLC26A6 in duodenal mucosa, which could contribute to protection of the duodenum and explain the sex difference in the prevalence of duodenal ulcer.<\/jats:p><\/jats:sec>","DOI":"10.1113\/ep085803","type":"journal-article","created":{"date-parts":[[2016,9,12]],"date-time":"2016-09-12T10:23:43Z","timestamp":1473675823000},"page":"1371-1382","source":"Crossref","is-referenced-by-count":17,"title":["Oestrogen upregulates the expression levels and functional activities of duodenal mucosal CFTR and SLC26A6"],"prefix":"10.1113","volume":"101","author":[{"given":"Hai","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Affiliated Hospital Zunyi Medical College  Zunyi China"},{"name":"Digestive Disease Institute of Guizhou Province  Zunyi China"},{"name":"Research Center of Medicine and Biology Zunyi Medical College  Zunyi 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