{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:22:20Z","timestamp":1762917740738,"version":"3.37.3"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,3,5]],"date-time":"2017-03-05T00:00:00Z","timestamp":1488672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["FS\/13\/5\/29927"],"award-info":[{"award-number":["FS\/13\/5\/29927"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec><jats:title>New Findings<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p><jats:bold>What is the central question of this study?<\/jats:bold><\/jats:p>\n<jats:p>Arterial hypertension is associated with impaired neurovascular coupling in the somatosensory cortex. Abnormalities in activity\u2010dependent oxygen consumption in brainstem regions involved in the control of cardiovascular reflexes have not been explored previously.<\/jats:p>\n<\/jats:list-item>\n<jats:list-item><jats:p><jats:bold>What is the main finding and its importance?<\/jats:bold><\/jats:p>\n<jats:p>Using fast\u2010cyclic voltammetry, we found that changes in local tissue <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/eph12059-math-0001.png\" xlink:title=\"urn:x-wiley:09580670:media:eph12059:eph12059-math-0001\"\/> in the nucleus tractus solitarii induced by electrical stimulation of the vagus nerve are significantly impaired in spontaneously hypertensive rats. This is consistent with previous observations showing that brainstem hypoxia plays an important role in the pathogenesis of arterial hypertension.<\/jats:p>\n<\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>The effects of arterial hypertension on cerebral blood flow remain poorly understood. Haemodynamic responses within the somatosensory cortex have been shown to be impaired in the spontaneously hypertensive rat (SHR) model. However, it is unknown whether arterial hypertension affects oxygen homeostasis in vital brainstem areas that control cardiovascular reflexes. In this study, we assessed vagus nerve stimulation\u2010induced changes in local tissue <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/eph12059-math-0002.png\" xlink:title=\"urn:x-wiley:09580670:media:eph12059:eph12059-math-0002\"\/> (<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/eph12059-math-0003.png\" xlink:title=\"urn:x-wiley:09580670:media:eph12059:eph12059-math-0003\"\/>) in the caudal nucleus tractus solitarii (cNTS) of SHRs and normotensive Wistar rats. Measurements of <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/eph12059-math-0004.png\" xlink:title=\"urn:x-wiley:09580670:media:eph12059:eph12059-math-0004\"\/> were performed using a novel application of fast\u2010cyclic voltammetry, which allows higher temporal resolution of O<jats:sub>2<\/jats:sub> changes than traditional optical fluorescence techniques. Electrical stimulation of the central cut end of the vagus nerve (ESVN) caused profound reductions in arterial blood pressure along with biphasic changes in <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/eph12059-math-0005.png\" xlink:title=\"urn:x-wiley:09580670:media:eph12059:eph12059-math-0005\"\/> in the cNTS, characterized by a rapid decrease in <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/eph12059-math-0006.png\" xlink:title=\"urn:x-wiley:09580670:media:eph12059:eph12059-math-0006\"\/> (\u2018initial dip\u2019) followed by a post\u2010stimulus overshoot above baseline. The initial dip was found to be significantly smaller in SHRs compared with normotensive Wistar rats even after ganglionic blockade. The post\u2010ESVN overshoot was similar in both groups but was reduced in Wistar rats after ganglionic blockade. In conclusion, neural activity\u2010dependent changes in tissue oxygen in brainstem cardiovascular autonomic centres are significantly impaired in animals with arterial hypertension.<\/jats:p><\/jats:sec>","DOI":"10.1113\/ep086023","type":"journal-article","created":{"date-parts":[[2017,1,25]],"date-time":"2017-01-25T07:23:01Z","timestamp":1485328981000},"page":"389-396","source":"Crossref","is-referenced-by-count":5,"title":["Abnormal oxygen homeostasis in the nucleus tractus solitarii of the spontaneously hypertensive rat"],"prefix":"10.1113","volume":"102","author":[{"given":"Patrick S.","family":"Hosford","sequence":"first","affiliation":[{"name":"Center for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology and Pharmacology University College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian","family":"Millar","sequence":"additional","affiliation":[{"name":"Barts and the London School of Medicine and Dentistry  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