{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:55:54Z","timestamp":1777416954300,"version":"3.51.4"},"reference-count":54,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,2,28]],"date-time":"2017-02-28T00:00:00Z","timestamp":1488240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["FRN: MOP\u2010136923"],"award-info":[{"award-number":["FRN: MOP\u2010136923"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010619","name":"University of Ottawa Heart Institute Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008572","name":"University of Ottawa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008572","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec><jats:title>New Findings<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p><jats:bold>What is the central question of this study?<\/jats:bold><\/jats:p>\n<jats:p>Exercise training increases brain\u2010derived neurotrophic factor (BDNF) in the hippocampus, which depends on a myokine, fibronectin type III domain\u2010containing protein 5 (FNDC5). Whether exercise training after myocardial infarction induces parallel increases in FNDC5 and BDNF expression in skeletal muscle and the heart has not yet been studied.<\/jats:p>\n<\/jats:list-item>\n<jats:list-item><jats:p><jats:bold>What is the main finding and its importance?<\/jats:bold><\/jats:p>\n<jats:p>Exercise training after myocardial infarction increases BDNF protein in skeletal muscle and the non\u2010infarct area of the LV without changes in FNDC5 protein, suggesting that BDNF is not regulated by FNDC5 in skeletal muscle and heart. An increase in cardiac BDNF may contribute to the improvement of cardiac function by exercise training.<\/jats:p>\n<\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>Exercise training after myocardial infarction (MI) attenuates progressive left ventricular (LV) remodelling and dysfunction, but the peripheral stimuli induced by exercise that trigger these beneficial effects are still unclear. We investigated as possible mediators fibronectin type III domain\u2010containing protein 5 (FNDC5) and brain\u2010derived neurotrophic factor (BDNF) in the skeletal muscle and heart. Male Wistar rats underwent either sham surgery or ligation of the left descending coronary artery, and surviving MI rats were allocated to either a sedentary (Sed\u2010MI) or an exercise group (ExT\u2010MI). Exercise training was done for 4\u00a0weeks on a motor\u2010driven treadmill. At the end, LV function was evaluated, and <jats:italic>FNDC5<\/jats:italic> and <jats:italic>BDNF<\/jats:italic> mRNA and protein were assessed in soleus muscle, quadriceps and non\u2010, peri\u2010 and infarct areas of the LV. At 5\u00a0weeks post MI, <jats:italic>FNDC5<\/jats:italic> mRNA was decreased in soleus muscle and all areas of the LV, but FNDC5 protein was increased in the soleus muscle and the infarct area. Mature BDNF (mBDNF) protein was decreased in the infarct area without a change in mRNA. Exercise training attenuated the decrease in ejection fraction and the increase in LV end\u2010diastolic pressure post MI. Exercise training had no effect on <jats:italic>FNDC5<\/jats:italic> mRNA and protein, but increased mBDNF protein in soleus muscle, quadriceps and the non\u2010infarct area of the LV. The mBDNF protein in the non\u2010infarct area correlated positively with ejection fraction and inversely with LV end\u2010diastolic pressure. In conclusion, mBDNF is induced by exercise training in skeletal muscle and the non\u2010infarct area of the LV, which may contribute to improvement of muscle dysfunction and cardiac function post MI.<\/jats:p><\/jats:sec>","DOI":"10.1113\/ep086049","type":"journal-article","created":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T04:53:01Z","timestamp":1484023981000},"page":"314-328","source":"Crossref","is-referenced-by-count":30,"title":["Effects of exercise training on brain\u2010derived neurotrophic factor in skeletal muscle and heart of rats post myocardial infarction"],"prefix":"10.1113","volume":"102","author":[{"given":"Heow Won","family":"Lee","sequence":"first","affiliation":[{"name":"Hypertension Unit University of Ottawa Heart Institute  Ottawa ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monir","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Hypertension Unit University of Ottawa Heart Institute  Ottawa ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong\u2010Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Hypertension Unit University of Ottawa Heart Institute  Ottawa ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8497-4416","authenticated-orcid":false,"given":"Frans H. 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