{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T10:29:33Z","timestamp":1783420173027,"version":"3.54.6"},"reference-count":49,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004263","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio Grande do Sul","doi-asserted-by":"publisher","award":["11\/2031\u20102"],"award-info":[{"award-number":["11\/2031\u20102"]}],"id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["307850"],"award-info":[{"award-number":["307850"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["23038.007213"],"award-info":[{"award-number":["23038.007213"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2017,11]]},"abstract":"New Findings<\/jats:title>\nWhat is the central question of this study?<\/jats:bold><\/jats:p>\nTo the best of our knowledge, no studies have evaluated oxygen uptake, carbon dioxide production and exercise tolerance in rats that have undergone myocardial infarction classified by myocardial infarct (MI) size.<\/jats:p>\n<\/jats:list-item>\nWhat is the main finding and its importance?<\/jats:bold><\/jats:p>\nOxygen uptake and exercise intolerance are MI size dependent, and classification based on MI size can distinguish rats with functional capacity impairment. Rats with a large MI (>40% of the left ventricle) might provide a good model for the testing of new therapies that have the potential to modify the variables of functional capacity.<\/jats:p>\n<\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>Oxygen uptake () and exercise tolerance in rats classified by myocardial infarct (MI) size are underexplored. The aim of this study was to evaluate , carbon dioxide production () and exercise tolerance in rats that had undergone myocardial infarction. Fourteen weeks after myocardial infarction or sham surgery, rats underwent an integrated approach to evaluation of left ventricular function and , exercise tolerance and skeletal muscle weight. Based on determination of MI size, rats were assigned to sham\u2010operated controls (Sham, n<\/jats:italic>\u00a0=\u00a012), small myocardial infarction (SMI, n<\/jats:italic>\u00a0=\u00a08) and large myocardial infarction (LMI, n<\/jats:italic>\u00a0=\u00a05) groups. The LMI rats showed lower systolic (ejection fraction and fractional shortening) and diastolic (E\/A ratio) left ventricular function compared with SMI. Maximal (\u223c24%, P<\/jats:italic>\u00a0<\u00a00.05), reserve (\u223c30%, P<\/jats:italic>\u00a0<\u00a00.05), time to exhaustion (\u223c36%, P<\/jats:italic>\u00a0<\u00a00.05) and maximal velocity (\u223c30%, P<\/jats:italic>\u00a0<\u00a00.05) were lower in LMI compared with sham\u2010operated control animals, with no difference between SMI rats and sham\u2010operated controls. Maximal and respiratory exchange ratio showed no significant difference between MI rats and sham\u2010operated control rats. The LMI rats demonstrated lower gastrocnemius weight (\u223c12%, P<\/jats:italic>\u00a0<\u00a00.05) and soleus weight (\u223c19%, P<\/jats:italic>\u00a0=\u00a00.07) compared with sham\u2010operated control rats. Significant correlations between MI size, left ventricular end\u2010diastolic pressure, right ventricle hypertrophy, pulmonary congestion, ejection fraction and fractional shortening with maximal and distance run were observed. Oxygen uptake and exercise intolerance are MI size dependent.<\/jats:p><\/jats:sec>","DOI":"10.1113\/ep086076","type":"journal-article","created":{"date-parts":[[2017,8,25]],"date-time":"2017-08-25T12:46:39Z","timestamp":1503665199000},"page":"1448-1458","source":"Crossref","is-referenced-by-count":11,"title":["Functional capacity in a rat model of heart failure: impact of myocardial infarct size"],"prefix":"10.1113","volume":"102","author":[{"given":"V\u00edtor Scotta","family":"Hentschke","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Fisiologia Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre (UFCSPA) Porto Alegre Rio Grande do Sul Brazil"},{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre (UFCSPA) Porto Alegre Rio Grande do Sul 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