{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T01:08:19Z","timestamp":1787620099974,"version":"build-2736575974"},"reference-count":54,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,7,5]],"date-time":"2017-07-05T00:00:00Z","timestamp":1499212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006162","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Ci\u00eancia e Tecnologia do Estado de Pernambuco","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006162","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec><jats:title>New Findings<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p><jats:bold>What is the central question of this study?<\/jats:bold><\/jats:p>\n<jats:p>Hyperglycaemia during pregnancy induces vascular dysfunction and hypertension in male offspring. Given that female offspring from other fetal programming models are protected from the effects of fetal insult, the present study investigated whether there are sex differences in blood pressure and vascular function in hyperglycaemia\u2010programmed offspring.<\/jats:p>\n<\/jats:list-item>\n<jats:list-item><jats:p><jats:bold>What is the main finding and its importance?<\/jats:bold><\/jats:p>\n<jats:p>We demonstrated that hyperglycaemia in pregnant rats induced vascular dysfunction and hypertension only in male offspring. We found sex differences in oxidative stress and cyclooxygenase\u20102\u2010derived prostanoid production that might underlie the vascular dysfunction. These differences, particularly in resistance arteries, may in part explain the absence of hypertension in female offspring born to hyperglycaemic dams.<\/jats:p>\n<\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>Exposure to maternal hyperglycaemia induces hypertension and vascular dysfunction in adult male offspring. Given that female offspring from several fetal programming models are protected from the effects of fetal insult, in this study we analysed possible differences relative to sex in blood pressure and vascular function in hyperglycaemia\u2010programmed offspring. Hyperglycaemia was induced on day 7 of gestation (streptozotocin, 50\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup>). Blood pressure, acetylcholine and phenylephrine or noradrenaline responses were analysed in the aorta and mesenteric resistance arteries of 3\u2010, 6\u2010 and 12\u2010month\u2010old male and female offspring. Thromboxane\u00a0A<jats:sub>2<\/jats:sub> release was analysed with commercial kits and superoxide anion (O<jats:sub>2<\/jats:sub><jats:sup>\u2212<\/jats:sup>) production by dihydroethidium\u2010emitted fluorescence. Male but not female offspring of hyperglycaemic dams (O\u2010DR) had higher blood pressure than control animals (O\u2010CR). Contraction in response to phenylephrine increased and relaxation in response to acetylcholine decreased only in the aorta from 12\u2010month\u2010old male O\u2010DR and not in age\u2010matched O\u2010CR. Contractile and vasodilator responses were preserved in both the aorta and mesenteric resistance arteries from female O\u2010DR of all ages. Pre\u2010incubation with tempol, superoxide dismutase, indomethacin, NS\u2010398, furegrelate or SQ29548 decreased contraction in response to phenylephrine and potentiated relaxation in response to acetylcholine in 12\u2010month\u2010old male O\u2010DR aorta. In this artery, thromboxane\u00a0A<jats:sub>2<\/jats:sub> release and O<jats:sub>2<\/jats:sub><jats:sup>\u2212<\/jats:sup> generation were greater in O\u2010DR than O\u2010CR groups. In conclusion, exposure to hyperglycaemia <jats:italic>in utero<\/jats:italic> results in sex\u2010specific and age\u2010dependent hypertension. The fact that vascular function is preserved in female O\u2010DR may in part explain the absence of hypertension in this group. In contrast, the peripheral artery dysfunction associated with increased cyclooxygenase\u20102\u2010derived production of vasoconstrictor prostanoids could underlie the increased blood pressure in male O\u2010DR.<\/jats:p><\/jats:sec>","DOI":"10.1113\/ep086132","type":"journal-article","created":{"date-parts":[[2017,5,30]],"date-time":"2017-05-30T13:52:15Z","timestamp":1496152335000},"page":"1019-1036","source":"Crossref","is-referenced-by-count":13,"title":["Hyperglycaemia in pregnant rats causes sex\u2010related vascular dysfunction in adult offspring: role of cyclooxygenase\u20102"],"prefix":"10.1113","volume":"102","author":[{"given":"Francine Gomes","family":"de S\u00e1","sequence":"first","affiliation":[{"name":"Departamento de Fisiologia e Farmacologia Universidade Federal de Pernambuco  Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego Barbosa","family":"de Queiroz","sequence":"additional","affiliation":[{"name":"Departamento de Fisiologia e 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