{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T15:41:29Z","timestamp":1780414889729,"version":"3.54.1"},"reference-count":65,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,5,31]],"date-time":"2017-05-31T00:00:00Z","timestamp":1496188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000844","name":"European Space Agency","doi-asserted-by":"publisher","award":["40001043721\/11\/NL\/KML"],"award-info":[{"award-number":["40001043721\/11\/NL\/KML"]}],"id":[{"id":"10.13039\/501100000844","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2017,6]]},"abstract":"New Findings<\/jats:title>\nWhat is the central question of this study?<\/jats:bold><\/jats:p>\nWhat are the distinct and interactive effects of a 10\u00a0day exposure to hypoxia and horizontal bedrest on the whole\u2010body peak oxygen uptake and on the regional cerebral and skeletal muscle tissue oxygenation during upright cycle ergometry in male lowlanders?<\/jats:p>\n<\/jats:list-item>\nWhat is the main finding and its importance?<\/jats:bold><\/jats:p>\nA 10\u00a0day sustained exposure to hypoxia aggravates the bedrest\u2010induced reduction in peak oxygen uptake during dynamic exercise engaging large muscle groups, but mitigates the skeletal muscle oxidative capacity impairment elicited by bedrest.<\/jats:p>\n<\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>The study examined the interactive effects of a 10\u00a0day exposure to hypoxia and bedrest on the whole\u2010body peak oxygen uptake () during maximal exercise and on skeletal muscle and cerebral oxygenation during submaximal exercise. Nine males underwent three 10\u00a0day confinements, in a Latin\u2010square order, as follows: (i) a normoxic bedrest [NBR; partial pressure of inspired O2<\/jats:sub> ()\u00a0=\u00a0134.2\u00a0\u00b1\u00a00.7\u00a0mmHg]; (ii) a hypoxic bedrest (HBR; \u00a0=\u00a0102.9\u00a0\u00b1\u00a00.1\u00a0mmHg at day\u00a01, 91.5\u00a0\u00b1\u00a01.2\u00a0mmHg at days\u00a03\u201310); and (iii) a hypoxic ambulation (HAMB; as in HBR). Before, 1 (R+1) and 3\u00a0days (R+3) after each confinement, subjects performed exhaustive, incremental\u2010load and moderate\u2010intensity constant\u2010load (CLTs) cycle\u2010ergometry trials, while breathing either room air or a hypoxic gas mixture. During the CLTs, changes in the regional oxygenation of the cerebral frontal cortex and the vastus lateralis and intercostal muscles were monitored with near\u2010infrared spectroscopy. At R+1, the confinement\u2010related impairment in was greater after HBR than after NBR or HAMB, regardless of whether the trial was performed in room air or hypoxia (HBR, \u221216.2%; NBR, \u22128.3%; HAMB, \u22124.1%; P<\/jats:italic>\u00a0=\u00a00.001). During the CLTs, bedrest aggravated the exercise\u2010induced reduction in locomotor and respiratory muscle oxygenation (P\u00a0\u2264\u00a0<\/jats:italic>0.05); an effect that was less after HBR than after NBR (P\u00a0\u2264\u00a0<\/jats:italic>0.05). The hypoxic exercise\u2010induced cerebral vasodilatory response was blunted by HBR, probably because of the marked hyperventilation\u2010dependent hypocapnia, attendant to the sustained hypoxic stimulus. Hence, short\u2010term exposure to hypoxia potentiates the reduction in , but it mitigates the impairment in skeletal muscle oxidative capacity induced by bedrest.<\/jats:p><\/jats:sec>","DOI":"10.1113\/ep086167","type":"journal-article","created":{"date-parts":[[2017,4,10]],"date-time":"2017-04-10T03:52:47Z","timestamp":1491796367000},"page":"694-710","source":"Crossref","is-referenced-by-count":6,"title":["LunHab: interactive effects of a 10\u00a0day sustained exposure to hypoxia and bedrest on aerobic exercise capacity in male lowlanders"],"prefix":"10.1113","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7440-2171","authenticated-orcid":false,"given":"Michail E.","family":"Keramidas","sequence":"first","affiliation":[{"name":"Department of Environmental Physiology Swedish Aerospace Physiology Center School of Technology and Health Royal Institute of Technology Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor 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