{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:33:00Z","timestamp":1791261180832,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T00:00:00Z","timestamp":1495497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000924","name":"Multiple Sclerosis Research Australia","doi-asserted-by":"publisher","award":["14\u2010009"],"award-info":[{"award-number":["14\u2010009"]}],"id":[{"id":"10.13039\/501100000924","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003521","name":"Department of Education, Australian Governement","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003521","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec><jats:title>New Findings<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p><jats:bold>What is the central question of this study?<\/jats:bold><\/jats:p>\n<jats:p>Between 60 and 80% of multiple sclerosis (MS) patients experience transient worsening of symptoms with increased body temperature (heat sensitivity). As sensory abnormalities are common in MS, we asked whether afferent thermosensory function is altered in MS following exercise\u2010induced increases in body temperature.<\/jats:p>\n<\/jats:list-item>\n<jats:list-item><jats:p><jats:bold>What is the main finding and its importance?<\/jats:bold><\/jats:p>\n<jats:p>Increases in body temperature of as little as \u223c0.4\u00b0C were sufficient to decrease cold, but not warm, skin thermosensitivity (\u223c10%) in MS, across a wider temperature range than in age\u2010matched healthy individuals. These findings provide new evidence on the impact of heat sensitivity on afferent function in MS, which could be useful for clinical evaluation of this neurological disease.<\/jats:p>\n<\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>In multiple sclerosis (MS), increases in body temperature result in transient worsening of clinical symptoms (heat sensitivity or Uhthoff's phenomenon). Although the impact of heat sensitivity on efferent physiological function has been investigated, the effects of heat stress on afferent sensory function in MS are unknown. Hence, we quantified afferent thermosensory function in MS following exercise\u2010induced increases in body temperature with a new quantitative sensory test. Eight relapsing\u2013remitting MS patients (three men and five women; 51.4\u00a0\u00b1\u00a09.1\u00a0years of age; Expanded Disability Status Scale score 2.8\u00a0\u00b1\u00a01.1) and eight age\u2010matched control (CTR) subjects (five men and three women; 47.4\u00a0\u00b1\u00a09.1\u00a0years of age) rated the perceived magnitude of two cold (26 and 22\u00b0C) and two warm stimuli (34 and 38\u00b0C) applied to the dorsum of the hand before and after 30\u00a0min cycling in the heat (30\u00b0C air; 30% relative humidity). Exercise produced similar increases in mean body temperature in MS [+0.39\u00b0C (95% CI: +0.21, +0.53) <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001] and CTR subjects [+0.41\u00b0C (95% CI: +0.25, +0.58) <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001]. These changes were sufficient to decrease thermosensitivity significantly to all cold [26\u00b0C stimulus, \u22129.1% (95% CI: \u221217.0, \u22121.5), <jats:italic>P<\/jats:italic>\u00a0=\u00a00.006; 22\u00b0C stimulus, \u221210.6% (95% CI: \u221217.3, \u22123.7), <jats:italic>P<\/jats:italic>\u00a0=\u00a00.027], but not warm, stimuli in MS. Contrariwise, CTR subjects showed sensitivity reductions to colder stimuli only [22\u00b0C stimulus, \u22129.7% (95% CI: \u221216.4, \u22123.1), <jats:italic>P<\/jats:italic>\u00a0=\u00a00.011]. The observation that reductions in thermal sensitivity in MS were confined to the myelinated cold\u2010sensitive pathway and extended across a wider (including milder and colder) temperature range than what is observed in CTR subjects provides new evidence on the impact of rising body temperature on afferent neural function in MS. Also, our findings support the use of our new approach to investigate afferent sensory function in MS during heat stress.<\/jats:p><\/jats:sec>","DOI":"10.1113\/ep086320","type":"journal-article","created":{"date-parts":[[2017,5,10]],"date-time":"2017-05-10T06:53:15Z","timestamp":1494399195000},"page":"887-893","source":"Crossref","is-referenced-by-count":28,"title":["Afferent thermosensory function in relapsing\u2013remitting multiple sclerosis following exercise\u2010induced increases in body temperature"],"prefix":"10.1113","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5652-395X","authenticated-orcid":false,"given":"Davide","family":"Filingeri","sequence":"first","affiliation":[{"name":"Thermal Ergonomics Laboratory, Faculty of Health Sciences University of Sydney  Sydney NSW Australia"},{"name":"Environmental Ergonomics Research Centre, Loughborough Design School Loughborough University  Loughborough UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia","family":"Chaseling","sequence":"additional","affiliation":[{"name":"Thermal Ergonomics Laboratory, Faculty of Health Sciences University of Sydney  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phu","family":"Hoang","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia  Randwick NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Barnett","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre University of Sydney  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott L.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Applied Physiology &amp; Wellness Southern Methodist University  Dallas TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6076-6337","authenticated-orcid":false,"given":"Ollie","family":"Jay","sequence":"additional","affiliation":[{"name":"Thermal Ergonomics Laboratory, Faculty of Health Sciences University of Sydney  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,23]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00897.2016"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000291009.69226.4d"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00460.2010"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1996.76.6.3656"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.3758\/BF03193146"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c150040"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00120.2014"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP085955"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00845.2016"},{"key":"e_1_2_2_11_1","volume-title":"Compr Physiol 2011, Supplement 14: Handbook of Physiology, Environmental Physiology: 45\u201384","author":"Gagge AP","year":"1996"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-014-2875-0"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00393.2002"},{"key":"e_1_2_2_14_1","doi-asserted-by":"publisher","DOI":"10.1123\/japa.5.1.39"},{"key":"e_1_2_2_15_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP273963"},{"key":"e_1_2_2_16_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP274183"},{"key":"e_1_2_2_17_1","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-200029020-00002"},{"key":"e_1_2_2_18_1","doi-asserted-by":"publisher","DOI":"10.1191\/1352458503ms908oa"},{"key":"e_1_2_2_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200009283431307"},{"key":"e_1_2_2_20_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI43766"},{"key":"e_1_2_2_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtherbio.2012.06.003"},{"key":"e_1_2_2_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458513488230"},{"key":"e_1_2_2_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2011.02.002"},{"key":"e_1_2_2_24_1","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-200434150-00005"}],"container-title":["Experimental Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2FEP086320","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/EP086320","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T12:09:33Z","timestamp":1695989373000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/EP086320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,23]]},"references-count":23,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1113\/EP086320"],"URL":"https:\/\/doi.org\/10.1113\/ep086320","archive":["Portico"],"relation":{},"ISSN":["0958-0670","1469-445X"],"issn-type":[{"value":"0958-0670","type":"print"},{"value":"1469-445X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,23]]}}}