{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T07:10:26Z","timestamp":1782889826249,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,11,2]],"date-time":"2017-11-02T00:00:00Z","timestamp":1509580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001596","name":"Irish Research Council for Science, Engineering and Technology","doi-asserted-by":"publisher","award":["R13742"],"award-info":[{"award-number":["R13742"]}],"id":[{"id":"10.13039\/501100001596","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec><jats:title>New Findings<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p><jats:bold>What is the central question of this study?<\/jats:bold><\/jats:p>\n<jats:p>Dietary sodium manipulation alters the magnitude of angiotensin\u2010(1\u20137) [Ang\u2010(1\u20137)]\u2010induced natriuresis. The present study sought to determine whether this was related to relative changes in the activity of intrarenal Mas and\/or AT<jats:sub>1<\/jats:sub> receptors.<\/jats:p>\n<\/jats:list-item>\n<jats:list-item><jats:p><jats:bold>What is the main finding and its importance?<\/jats:bold><\/jats:p>\n<jats:p>Angiotensin\u2010(1\u20137)\u2010induced diuresis and natriuresis is mediated by intrarenal Mas receptors. However, intrarenal AT<jats:sub>1<\/jats:sub> receptor blockade also had an inhibitory effect on Ang\u2010(1\u20137)\u2010induced natriuresis and diuresis. Thus, Ang\u2010(1\u20137)\u2010induced increases in sodium and water excretion are dependent upon functional Mas and AT<jats:sub>1<\/jats:sub> receptors.<\/jats:p>\n<\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>We investigated whether angiotensin\u2010(1\u20137) [Ang\u2010(1\u20137)]\u2010induced renal haemodynamic and excretory actions were solely dependent upon intrarenal Mas receptor activation or required functional angiotensin\u00a0II type 1 (AT<jats:sub>1<\/jats:sub>) receptors. The renin\u2013angiotensin system was enhanced in anaesthetized rats by prior manipulation of dietary sodium intake. Angiotensin\u2010(1\u20137) and AT<jats:sub>1<\/jats:sub> and Mas receptor antagonists were infused into the kidney at the corticomedullary border. Mas receptor expression was measured in the kidney. Mean arterial pressure, urine flow and fractional sodium excretion were 93\u00a0\u00b1\u00a04\u00a0mmHg, 46.1\u00a0\u00b1\u00a015.7\u00a0\u03bcl\u00a0min<jats:sup>\u22121<\/jats:sup>\u00a0kg<jats:sup>\u22121<\/jats:sup> and 1.4\u00a0\u00b1\u00a00.3%, respectively, in the normal\u2010sodium group and 91\u00a0\u00b1\u00a02\u00a0mmHg, 19.1\u00a0\u00b1\u00a03.3\u00a0\u03bcl\u00a0min<jats:sup>\u22121<\/jats:sup>\u00a0kg<jats:sup>\u22121<\/jats:sup> and 0.7\u00a0\u00b1\u00a00.2%, respectively, in the low\u2010sodium group. Angiotensin\u2010(1\u20137) infusion had no effect on mean arterial pressure in rats receiving a normal\u2010sodium diet but decreased it by 4\u00a0\u00b1\u00a05% in rats receiving a low\u2010sodium diet (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Interstitial Ang\u2010(1\u20137) infusion increased urine flow twofold and fractional sodium excretion threefold (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) in rats receiving a normal\u2010sodium diet and to a greater extent, approximately three\u2010 and fourfold, respectively, in rats receiving the low\u2010sodium diet (both <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Angiotensin\u2010(1\u20137)\u2010induced increases in urine flow and fractional sodium excretion were absent in both dietary groups during intrarenal AT<jats:sub>1<\/jats:sub> or Mas receptor inhibition after either losartan or A\u2010779, respectively. Thus, AT<jats:sub>1<\/jats:sub> receptor activation, as well as Mas receptor activation, plays an essential role in mediating Ang\u2010(1\u20137)\u2010induced natriuresis and diuresis. Whether this is because Ang\u2010(1\u20137) partly antagonizes AT<jats:sub>1<\/jats:sub> receptors or whether Ang\u2010(1\u20137)\u2010induced natriuresis is mediated through AT<jats:sub>1<\/jats:sub>\u2013Mas receptor dimerization remains unclear.<\/jats:p><\/jats:sec>","DOI":"10.1113\/ep086513","type":"journal-article","created":{"date-parts":[[2017,9,21]],"date-time":"2017-09-21T11:53:00Z","timestamp":1505994780000},"page":"1700-1715","source":"Crossref","is-referenced-by-count":15,"title":["Intrarenal Mas and AT<sub>1<\/sub> receptors play a role in mediating the excretory actions of renal interstitial angiotensin\u2010(1\u20137) infusion in anaesthetized rats"],"prefix":"10.1113","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9045-5230","authenticated-orcid":false,"given":"Julie","family":"O'Neill","sequence":"first","affiliation":[{"name":"Department of Physiology University College Cork  Cork Republic of 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