{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:50:29Z","timestamp":1788281429947,"version":"build-2803163510"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,2,14]],"date-time":"2018-02-14T00:00:00Z","timestamp":1518566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["12Pre\u201012080242"],"award-info":[{"award-number":["12Pre\u201012080242"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32\u20105T32AR048523\u201009"],"award-info":[{"award-number":["T32\u20105T32AR048523\u201009"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["RO1\u2010HL 093167"],"award-info":[{"award-number":["RO1\u2010HL 093167"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:title>New Findings<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p><jats:bold>What is the central question of this study?<\/jats:bold><\/jats:p>\n<jats:p>To understand better the effects of acute hyperglycaemia on arterial stiffness in healthy young individuals, we assessed arterial stiffness in physically active men before and after reduced ambulatory physical activity to decrease insulin sensitivity.<\/jats:p>\n<\/jats:list-item>\n<jats:list-item><jats:p><jats:bold>What is the main finding and its importance?<\/jats:bold><\/jats:p>\n<jats:p>During an oral glucose tolerance test, we identified an increase in leg arterial stiffness (i.e. reduced femoral artery compliance) only when subjects were inactive for 5\u00a0days (&lt;5000\u00a0steps\u00a0day<jats:sup>\u22121<\/jats:sup>) and not when they were engaging in regular physical activity (&gt;10,000\u00a0steps\u00a0day<jats:sup>\u22121<\/jats:sup>). These results demonstrate the deleterious consequence of acute reductions in daily physical activity on the response of the peripheral vasculature to acute hyperglycaemia.<\/jats:p>\n<\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Acute hyperglycaemia has been shown to augment indices of arterial stiffness in patients with insulin resistance and other co\u2010morbidities; however, conflicting results exist in healthy young individuals. We examined whether acute hyperglycaemia after an oral glucose tolerance test (OGTT) increases arterial stiffness in healthy active men before and after reduced ambulatory physical activity to decrease insulin sensitivity. High\u2010resolution arterial diameter traces acquired from Doppler ultrasound allowed an arterial blood pressure (BP) waveform to be obtained from the diameter trace within a cardiac cycle. In 24 subjects, this method demonstrated sufficient agreement with the traditional approach for assessing arterial compliance using applanation tonometry. In 10\u00a0men, continuous recordings of femoral and brachial artery diameter and beat\u2010to\u2010beat BP (Finometer) were acquired at rest, 60 and 120\u00a0min of an OGTT before and after 5\u00a0days of reduced activity (from &gt;10,000 to\u00a0&lt;5000\u00a0steps\u00a0day<jats:sup>\u22121<\/jats:sup>). Compliance and \u03b2\u2010stiffness were quantified. Before the reduction in activity, the OGTT had no effect on arterial compliance or \u03b2\u2010stiffness. However, after the reduction in activity, femoral compliance was decreased (rest, 0.10\u00a0\u00b1\u00a00.03\u00a0mm<jats:sup>2<\/jats:sup>\u00a0mmHg<jats:sup>\u22121<\/jats:sup> <jats:italic>versus<\/jats:italic> 120\u00a0min OGTT, 0.06\u00a0\u00b1\u00a00.02\u00a0mm<jats:sup>2<\/jats:sup>\u00a0mmHg<jats:sup>\u22121<\/jats:sup>; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and femoral \u03b2\u2010stiffness increased (rest, 8.7\u00a0\u00b1\u00a02.7\u00a0a.u. <jats:italic>versus<\/jats:italic> 120\u00a0min OGTT, 15.3\u00a0\u00b1\u00a06.5\u00a0a.u.; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) during OGTT, whereas no changes occurred in brachial artery compliance (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.182) or stiffness (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.892). Insulin sensitivity (Matsuda index) was decreased after the reduction in activity (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.002). In summary, in young healthy men the femoral artery becomes susceptible to acute hyperglycaemia after 5\u00a0days of reduced activity and the resultant decrease in insulin sensitivity, highlighting the strong influence of daily physical activity levels on vascular physiology.<\/jats:p><\/jats:sec>","DOI":"10.1113\/ep086713","type":"journal-article","created":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T12:38:26Z","timestamp":1515587906000},"page":"483-494","source":"Crossref","is-referenced-by-count":9,"title":["Influence of physical inactivity on arterial compliance during a glucose challenge"],"prefix":"10.1113","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5084-2666","authenticated-orcid":false,"given":"Daniel P.","family":"Credeur","sequence":"first","affiliation":[{"name":"School of Kinesiology University of Southern Mississippi  Hattiesburg MS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leryn J.","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Department of Human Movement Sciences Old Dominion University  Norfolk VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth W.","family":"Holwerda","sequence":"additional","affiliation":[{"name":"Department of Health and Human Physiology University of Iowa  Iowa City IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer R.","family":"Vranish","sequence":"additional","affiliation":[{"name":"Department of Kinesiology University of Texas at Arlington  Arlington TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin E.","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Kinesiology University of Texas at Arlington  Arlington TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Nursing University of Texas at Arlington  Arlington TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7920-7466","authenticated-orcid":false,"given":"John P.","family":"Thyfault","sequence":"additional","affiliation":[{"name":"Department of Molecular and Integrative Physiology University of Kansas Medical Center  Kansas City KS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Fadel","sequence":"additional","affiliation":[{"name":"Department of Kinesiology University of Texas at Arlington  Arlington TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1258\/ebm.2009.009186"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-097X.1985.tb00747.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3181dc2e54"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST0330354"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/096228029900800204"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00837.2013"},{"key":"e_1_2_8_8_1","unstructured":"Centers for Disease Control and Prevention. 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