{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T18:43:02Z","timestamp":1785523382332,"version":"3.56.0"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T00:00:00Z","timestamp":1516320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2012\/01417\u20100"],"award-info":[{"award-number":["2012\/01417\u20100"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2015\/24950\u20103"],"award-info":[{"award-number":["2015\/24950\u20103"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2016\/17681\u20109"],"award-info":[{"award-number":["2016\/17681\u20109"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec><jats:title>New Findings<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p><jats:bold>What is the central question of this study?<\/jats:bold><\/jats:p>\n<jats:p>In fever, the most striking response in the acute phase\n reaction of systemic inflammation, plasma H<jats:sub>2<\/jats:sub>S concentration increases. However, the role of endogenous peripheral H<jats:sub>2<\/jats:sub>S in fever is unknown.<\/jats:p>\n<\/jats:list-item>\n<jats:list-item><jats:p><jats:bold>What is the main finding and its importance?<\/jats:bold><\/jats:p>\n<jats:p>Endogenous peripheral H<jats:sub>2<\/jats:sub>S is permissive for increased brown adipose tissue thermogenesis to maintain thermal homeostasis in cold environments as well as to mount fever. This finding expands the physiological role of the gaseous modulator as a key regulator of thermal control in health (thermal homeostasis) and disease (fever in systemic inflammation).<\/jats:p>\n<\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>In recent years, hydrogen sulfide (H<jats:sub>2<\/jats:sub>S) has been reported as a gaseous modulator acting in several tissues in health and disease. In animal models of systemic inflammation, the plasma H<jats:sub>2<\/jats:sub>S concentration increases in response to endotoxin (bacterial lipopolysaccharide, LPS). The most striking response in the acute phase reaction of systemic inflammation is fever, but we found no reports of the peripheral action of H<jats:sub>2<\/jats:sub>S on this thermoregulatory response. We aimed at investigating whether endogenous systemic H<jats:sub>2<\/jats:sub>S modulates LPS\u2010induced fever. A temperature datalogger capsule was inserted in the abdominal cavity of male Wistar rats (220\u2013270\u00a0g) to record body core temperature. These animals received an <jats:sc>i.p<\/jats:sc>. injection of a systemic H<jats:sub>2<\/jats:sub>S inhibitor (propargylglycine; 50 or 75\u00a0mg kg<jats:sup>\u22121<\/jats:sup>), immediately followed by an <jats:sc>i.p<\/jats:sc>. injection of LPS (50 or 2500\u00a0\u03bcg kg<jats:sup>\u22121<\/jats:sup>), and were exposed to different ambient temperatures (16, 22 or 27\u00b0C). At 22\u00b0C, but not at 27\u00b0C, propargylglycine at 75\u00a0mg kg<jats:sup>\u22121<\/jats:sup> significantly attenuated (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001) the fever induced by LPS (50\u00a0\u03bcg kg<jats:sup>\u22121<\/jats:sup>), indicating a modulatory (permissive) action of endogenous peripheral H<jats:sub>2<\/jats:sub>S on brown adipose tissue (BAT) thermogenesis. Evidence on the modulatory role of peripheral H<jats:sub>2<\/jats:sub>S in BAT thermogenesis was strengthened when we discarded (i) the possible influence of the gas on febrigenic signalling (when measuring plasma cytokines), and (ii) its interaction with the nitric oxide pathway, and mainly when (iii) we carried out physiological and pharmacological activations of BAT. Endogenous peripheral H<jats:sub>2<\/jats:sub>S modulates (permits) BAT activity not only in fever but also during maintenance of thermal homeostasis in cold environments.<\/jats:p><\/jats:sec>","DOI":"10.1113\/ep086775","type":"journal-article","created":{"date-parts":[[2017,12,6]],"date-time":"2017-12-06T08:26:55Z","timestamp":1512548815000},"page":"397-407","source":"Crossref","is-referenced-by-count":15,"title":["Endogenous peripheral hydrogen sulfide is propyretic: its permissive role in brown adipose tissue thermogenesis in rats"],"prefix":"10.1113","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3295-8120","authenticated-orcid":false,"given":"Renato N.","family":"Soriano","sequence":"first","affiliation":[{"name":"Division of Physiology and Biophysics, Department of Basic Life Sciences Federal University of Juiz de Fora  Governador Valadares MG Brazil"},{"name":"Nursing School of Ribeir\u00e3o Preto Physiology University of S\u00e3o Paulo  Ribeir\u00e3o Preto SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara P.","family":"Braga","sequence":"additional","affiliation":[{"name":"Student of Physical Therapy Federal University of Juiz de Fora  Governador Valadares MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9ssica S. C.","family":"Breder","sequence":"additional","affiliation":[{"name":"Nursing School of Ribeir\u00e3o Preto Physiology University of S\u00e3o Paulo  Ribeir\u00e3o Preto SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo E.","family":"Batalhao","sequence":"additional","affiliation":[{"name":"Nursing School of Ribeir\u00e3o Preto Physiology University of S\u00e3o Paulo  Ribeir\u00e3o Preto SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela R.","family":"Oliveira\u2010Pelegrin","sequence":"additional","affiliation":[{"name":"Department of Morphology, Physiology and Basic Pathology, Dental School of Ribeir\u00e3o Preto University of S\u00e3o Paulo  Ribeir\u00e3o Preto SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Fernando R.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Tiradentes University  Aracaju SE Brazil"},{"name":"Institute of Technology and Research  Aracaju SE Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Jos\u00e9 A.","family":"Rocha","sequence":"additional","affiliation":[{"name":"Department of Morphology, Physiology and Basic Pathology, Dental School of Ribeir\u00e3o Preto University of S\u00e3o Paulo  Ribeir\u00e3o Preto SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelin C.","family":"Carnio","sequence":"additional","affiliation":[{"name":"Nursing School of Ribeir\u00e3o Preto Physiology University of S\u00e3o Paulo  Ribeir\u00e3o Preto SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz G. S.","family":"Branco","sequence":"additional","affiliation":[{"name":"Department of Morphology, Physiology and Basic Pathology, Dental School of Ribeir\u00e3o Preto University of S\u00e3o Paulo  Ribeir\u00e3o Preto SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-03-01066.1996"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2006.04854.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706696"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00463.2011"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1108581"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2005.10.013"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1086\/317522"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c130053"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00015.2003"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706367"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2016.08.047"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1139\/y79-039"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1991.71.1.93"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00158.2010"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2012.11.008"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-3583fje"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2009.04.014"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00023.2012"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1006\/niox.1997.0116"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.shk.0000183393.83272.de"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(95)02020-R"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.138.2.676"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00360-015-0907-7"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2012.01.021"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705713"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1162667"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00489.2005"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-009-0250-9"}],"container-title":["Experimental Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2FEP086775","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/EP086775","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T08:38:07Z","timestamp":1695631087000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/EP086775"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,19]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1113\/EP086775"],"URL":"https:\/\/doi.org\/10.1113\/ep086775","archive":["Portico"],"relation":{},"ISSN":["0958-0670","1469-445X"],"issn-type":[{"value":"0958-0670","type":"print"},{"value":"1469-445X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,19]]}}}