{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:02:39Z","timestamp":1790125359259,"version":"4.0.1"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T00:00:00Z","timestamp":1553472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec><jats:title>New Findings<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p><jats:bold>What is the central question of this study?<\/jats:bold><\/jats:p>\n<jats:p>Visceral ischaemia is one of the most feared complications during use of an intra\u2010aortic balloon pump. Using an animal model, we measured the flows at the abdominal level directly and examined flow patterns to enable investigation of flow patterns during the use of the intra\u2010aortic balloon pump.<\/jats:p>\n<\/jats:list-item>\n<\/jats:list><\/jats:p><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p><jats:bold>What is the main finding and its importance?<\/jats:bold><\/jats:p>\n<jats:p>We show that there is a significant balloon\u2010related reduction in superior mesenteric flow in both early and mid\u2010diastole.<\/jats:p>\n<\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>A number of previous studies have shown that blood flow in the visceral arteries is altered during intra\u2010aortic balloon pump (IABP) treatment. We used a porcine model to analyse the pattern of blood flow into the visceral arteries during IABP use. For this purpose, we measured the superior mesenteric, right renal and left renal flows before and during IABP support, using surgically placed flowmeters surrounding these visceral arteries. The superior mesenteric flow significantly decreased in early diastole (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and in mid\u2010diastole (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.003\u00a0<jats:italic>versus<\/jats:italic> early diastole), whereas in late diastole it increased again (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001\u00a0<jats:italic>versus<\/jats:italic> mid\u2010diastole). During systole, the flow was not significantly increased compared with late diastole (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.51), but it was significantly lower than at baseline (both <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Flows did not differ between right and left kidneys. Perfusion of either kidney did not change significantly in early diastole (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05), whereas it decreased significantly in mid\u2010diastole (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), rising dramatically in late diastole (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and with an additional slight increase in systole (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.054). This study provides important insights into abdominal flows during intra\u2010aortic pump counterpulsation. Furthermore, it supports the need to rethink the balloon design to avoid visceral ischaemia during circulatory assistance.<\/jats:p><\/jats:sec>","DOI":"10.1113\/ep086810","type":"journal-article","created":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T04:45:15Z","timestamp":1551415515000},"page":"643-653","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Superior mesenteric and renal flow patterns during intra\u2010aortic counterpulsation"],"prefix":"10.1113","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7376-7101","authenticated-orcid":false,"given":"Daniel M.","family":"Johnson","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery Maastricht University Hospital  Maastricht The Netherlands"},{"name":"Institute of Cardiovascular Sciences University of Birmingham  Birmingham 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Campus  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Matteucci","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Maastricht University Hospital  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana","family":"Luc\u00e0","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Maastricht University Hospital  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos G.","family":"Maessen","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Maastricht University Hospital  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7746-989X","authenticated-orcid":false,"given":"Sandro","family":"Gelsomino","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery 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