{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T20:28:40Z","timestamp":1793305720458,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,7,5]],"date-time":"2018-07-05T00:00:00Z","timestamp":1530748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs","doi-asserted-by":"publisher","award":["F16\u201002798"],"award-info":[{"award-number":["F16\u201002798"]}],"id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["F14\u201004752"],"award-info":[{"award-number":["F14\u201004752"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec><jats:title>New Findings<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p><jats:bold>What is the central question of this study<\/jats:bold>?<\/jats:p>\n<jats:p>How does oxygen therapy influence cerebral blood flow, cerebral oxygen delivery and neurovascular function in chronic obstructive pulmonary disease patients?<\/jats:p>\n<\/jats:list-item>\n<jats:list-item><jats:p><jats:bold>What is the main finding and its importance<\/jats:bold>?<\/jats:p>\n<jats:p>Oxygen therapy improves cerebral oxygen delivery and neurovascular function in chronic obstructive pulmonary disease patients. This improvement in cerebral oxygen delivery and neurovascular function might provide a physiological link between oxygen therapy and a reduced risk of cerebrovascular disease (e.g. stroke, mild cognitive impairment and dementia) in chronic obstructive pulmonary disease.<\/jats:p>\n<\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>We investigated the role of hypoxaemia in cerebral blood flow (CBF), oxygen delivery (CDO<jats:sub>2<\/jats:sub>) and neurovascular coupling (coupling of CBF to neural activity; NVC) in hypoxaemic chronic obstructive pulmonary disease (COPD) patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a014). Resting CBF (duplex ultrasound), peripheral oxyhaemoglobin saturation (<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/eph12310-math-0001.png\" xlink:title=\"urn:x-wiley:09580670:media:eph12310:eph12310-math-0001\"\/>; pulse\u2010oximetry) and NVC (transcranial Doppler) were assessed before and after a 20\u00a0min wash\u2010in of supplemental oxygen (\u223c3\u00a0l\u00a0min<jats:sup>\u22121<\/jats:sup>). The peripheral oxyhaemoglobin saturation increased from 91.0\u00a0\u00b1\u00a03.3 to 97.4\u00a0\u00b1\u00a03.0% (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01), whereas CBF was unaltered (593.0\u00a0\u00b1\u00a0162.8 <jats:italic>versus<\/jats:italic> 590.1\u00a0\u00b1\u00a0138.5\u00a0ml\u00a0min<jats:sup>\u22121<\/jats:sup>; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.91) with supplemental O<jats:sub>2<\/jats:sub>. In contrast, both CDO<jats:sub>2<\/jats:sub> (98.1\u00a0\u00b1\u00a025.7\u00a0<jats:italic>versus<\/jats:italic> 108.7\u00a0\u00b1\u00a028.4\u00a0ml\u00a0dl<jats:sup>\u22121<\/jats:sup>; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.02) and NVC were improved. Specifically, the posterior cerebral artery cerebrovascular conductance was increased to a greater extent after O<jats:sub>2<\/jats:sub> normalization (+40%, from 20.4\u00a0\u00b1\u00a09.9 to 28.0\u00a0\u00b1\u00a010.4% increase in conductance; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.04), whereas the posterior cerebral artery cerebrovascular resistance decreased to a greater extent during O<jats:sub>2<\/jats:sub> normalization (+22%, from \u221216.7\u00a0\u00b1\u00a07.3 to \u221221.4\u00a0\u00b1\u00a06.6% decrease in resistance; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.04). The cerebral vasculature of COPD patients appears insensitive to oxygen, because CBF was unaltered in response to O<jats:sub>2<\/jats:sub> supplementation leading to improved CDO<jats:sub>2<\/jats:sub>. In patients, the improvements in CDO<jats:sub>2<\/jats:sub> and neurovascular function with supplemental O<jats:sub>2<\/jats:sub> may underlie the cognitive benefits associated with O<jats:sub>2<\/jats:sub> therapy.<\/jats:p><\/jats:sec>","DOI":"10.1113\/ep086994","type":"journal-article","created":{"date-parts":[[2018,7,6]],"date-time":"2018-07-06T00:48:19Z","timestamp":1530838099000},"page":"1170-1177","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Oxygen therapy improves cerebral oxygen delivery and neurovascular function in hypoxaemic chronic obstructive pulmonary disease patients"],"prefix":"10.1113","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5657-0059","authenticated-orcid":false,"given":"Ryan L.","family":"Hoiland","sequence":"first","affiliation":[{"name":"Centre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences University of British Columbia \u2013 Okanagan Campus  Kelowna BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzana","family":"Mladinov","sequence":"additional","affiliation":[{"name":"Clinic for Pulmonary Diseases University Hospital Centre Split  Split Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otto F.","family":"Barak","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine University of Novi Sad  Novi Sad Serbia"},{"name":"Department of Integrative Physiology University of Split School of Medicine  Split Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher K.","family":"Willie","sequence":"additional","affiliation":[{"name":"Centre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences University of British Columbia \u2013 Okanagan Campus  Kelowna BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Mijacika","sequence":"additional","affiliation":[{"name":"Department of Integrative Physiology University of Split School of Medicine  Split Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0818-6420","authenticated-orcid":false,"given":"Mike","family":"Stembridge","sequence":"additional","affiliation":[{"name":"Cardiff Centre for Exercise and Health, Cardiff School of Sport and Health Sciences Cardiff Metropolitan University  Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeljko","family":"Dujic","sequence":"additional","affiliation":[{"name":"Department of Integrative Physiology University of Split School of Medicine  Split Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip N.","family":"Ainslie","sequence":"additional","affiliation":[{"name":"Centre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences University of British Columbia \u2013 Okanagan Campus  Kelowna BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00854.2014"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2006.01.015"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20160043"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2013.10.004"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00352.2017"},{"key":"e_1_2_7_7_1","first-page":"9","article-title":"Correction of hypoxia and hypercapnia in COPD patients: Effects on cerebrovascular flow","volume":"52","author":"Cannizzaro G.","year":"1997","journal-title":"Monaldi Archives for Chest Disease"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2009.128082"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.15.1.129"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP271981"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00270.2015"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-010-0718-6"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI101995"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2015.07.014"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12573"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1604344"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)91970-X"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-93-3-391"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(52)90219-2"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X15617954"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201505-0962OC"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-155-3-201108020-00008"},{"key":"e_1_2_7_23_1","first-page":"263","article-title":"COPD and cognitive impairment: The role of hypoxemia and oxygen therapy","volume":"5","author":"Thakur N.","year":"2010","journal-title":"International Journal of Chronic Obstructive Pulmonary Disease"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00211.2015"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200512-1957OC"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201204-0596PP"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2011.01.011"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2015.4"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.91.2.929"}],"container-title":["Experimental Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2FEP086994","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/EP086994","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T02:15:06Z","timestamp":1695003306000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/EP086994"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,5]]},"references-count":28,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1113\/EP086994"],"URL":"https:\/\/doi.org\/10.1113\/ep086994","archive":["Portico"],"relation":{},"ISSN":["0958-0670","1469-445X"],"issn-type":[{"value":"0958-0670","type":"print"},{"value":"1469-445X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,5]]},"assertion":[{"value":"2018-03-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}