{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:28:39Z","timestamp":1790731719648,"version":"4.1.0"},"reference-count":79,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,8,18]],"date-time":"2018-08-18T00:00:00Z","timestamp":1534550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec><jats:title>New Findings<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p><jats:bold>What<\/jats:bold> <jats:bold>is the topic of this review?<\/jats:bold><\/jats:p>\n<jats:p>The aim of this review is to discuss the potential involvement of exercise\u2010induced acidosis in the commonly reported complications in sickle cell disease.<\/jats:p>\n<\/jats:list-item>\n<jats:list-item><jats:p><jats:bold>What advances does it highlight?<\/jats:bold><\/jats:p>\n<jats:p>Blood acidosis appears clearly to be a risk factor for HbS polymerization, red blood cell sickling and the occurrence of vaso\u2010occlusive crisis and could induce hyperkalaemia\u2010related complications. It could be of great interest to try to avoid blood acidosis during exercise, which could be done using some alkalinizing solutions or adapted endurance training interventions.<\/jats:p>\n<\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Sickle cell disease (SCD) is an inherited haemoglobin (Hb) disorder and the most common monogenic disease in the world. The root cause of this pathology is the synthesis of an abnormal Hb (HbS) that polymerizes in deoxygenated conditions, leading to the sickling of red blood cells. Acidosis is well recognized as a promoter of HbS polymerization and therefore red blood cell sickling. Indeed, it has been shown <jats:italic>in vitro<\/jats:italic> that the relative amount of sickled red blood cells increases markedly from 1% at pH 7.4 to &gt;90% at pH 7.0. Nevertheless, no study has directly tested whether exercise\u2010induced acidosis could favour SCD complications. Greater knowledge of the effects of metabolic acidosis during exercise could be of importance given the conclusions reached in several studies that proposed regular physical exercise as a therapeutic strategy in the management of SCD. In this review, we discuss the potential consequences of exercise\u2010induced acidosis for the pathophysiology of SCD. We also propose some potential therapeutic interventions with the aim of reducing the metabolic acidosis related to exercise.<\/jats:p><\/jats:sec>","DOI":"10.1113\/ep087169","type":"journal-article","created":{"date-parts":[[2018,7,19]],"date-time":"2018-07-19T11:01:45Z","timestamp":1531998105000},"page":"1213-1220","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Do we have to consider acidosis induced by exercise as deleterious in sickle cell disease?"],"prefix":"10.1113","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8197-1903","authenticated-orcid":false,"given":"Benjamin","family":"Chatel","sequence":"first","affiliation":[{"name":"Laboratoire Interuniversitaire de Biologie de la Motricit\u00e9 Universit\u00e9 Savoie Mont Blanc  EA 7424 F\u201073000 Chamb\u00e9ry France"},{"name":"CNRS, CRMBM Aix\u2010Marseille Universit\u00e9  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent A.","family":"Messonnier","sequence":"additional","affiliation":[{"name":"Laboratoire Interuniversitaire de Biologie de la Motricit\u00e9 Universit\u00e9 Savoie Mont Blanc  EA 7424 F\u201073000 Chamb\u00e9ry France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Bendahan","sequence":"additional","affiliation":[{"name":"CNRS, CRMBM Aix\u2010Marseille Universit\u00e9  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,18]]},"reference":[{"issue":"1","key":"e_1_2_9_2_1","first-page":"214","article-title":"Sport participation in adolescents with sickle cell disease","volume":"6","author":"Al\u2010Rimawi H.","year":"2008","journal-title":"Pediatric Endocrinology Reviews"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/64.10.1520"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3233\/CH-2010-1270","article-title":"Sickle cell disease: Selected aspects of pathophysiology","volume":"44","author":"Alexy T.","year":"2010","journal-title":"Clinical Hemorheology and Microcirculation"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2011040414"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-10-534982"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3233\/CH-2009-1167","article-title":"Using serial haemorheological parameters to assess clinical status in sickle cell anaemia patients in vaso\u2010occlussive crisis","volume":"41","author":"Awodu O. 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