{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T06:54:55Z","timestamp":1767164095258,"version":"build-2238731810"},"reference-count":123,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T00:00:00Z","timestamp":1594857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["#201900987"],"award-info":[{"award-number":["#201900987"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec>\n                    <jats:title>New Findings<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>\n                            <jats:bold>What<\/jats:bold>\n                            <jats:bold>is the topic of this review?<\/jats:bold>\n                          <\/jats:p>\n                          <jats:p>This review explores the modulatory role of lung vagal afferents and intra\u2010neuraxial and carotid body chemoreceptors upon hypoglossal pre\u2010inspiratory activity.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            <jats:bold>What advances does it highlight?<\/jats:bold>\n                          <\/jats:p>\n                          <jats:p>Pre\u2010inspiratory activity manifesting in hypoglossal neural efferent discharge may be potentiated by mechanical interruption of vagal continuity and challenge with administration of a hypoxic and\/or hypercapnic gas mixture and attenuated by static and\/or dynamic pulmonary stretch. Differential excitability of, or premotoneuronal volleys exhibiting distinct spatiotemporal patterns of discharge arriving at, motoneurons residing within the hypoglossal motor nucleus may emergently generate phase\u2010spanning pre\u2010inspiratory inspiratory activity of hypoglossal neural efferent discharge manifest at the population level.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>The hypoglossal nerve (XII) innervates muscles mediating excursive movements of the tongue. The population discharge of hypoglossalmotoneuronal axons constituting the hypoglossal nerve precedes and extends through the inspiratory epoch. The epoch subtended between the onsets of hypoglossal and phrenic neural discharge constitutes so\u2010called pre\u2010inspiration. Hypoglossal pre\u2010inspiratory neural discharge serendipitously displaces the tongue along a tensor reducing upper airway resistance anticipative of succeeding inspiratory efforts. Hypoglossal motoneurons exhibiting discharge onset during pre\u2010inspiration experience successive hyperpolarization of membrane voltage and attenuation of unitary spiking frequency, although a subset may, paradoxically and state\u2010dependently, exhibit depolarization of membrane voltage and augmentation of neuronal spiking frequency, by dynamic stretch placed upon the alveolar walls and interstitium. Marked static elevation of positive\u2010end expiratory pressure may induce hypoglossal bursting decoupled from phasic rhythmic phrenic discharge. Augmentation of the amplitude and\/or duration of hypoglossal inspiratory discharge during successive pre\u2010inspiratory and inspiratory epochs by inhalation of a hypoxic and\/or hypercapnic gas mixture remains restrained in the presence of intact vagal inputs and is potentiated by interruptions of vagal continuity. Unravelling the mechanisms underlying the genesis of pre\u2010inspiratory activity will inform our understanding of respiratory rhythm generation and pattern shaping. In the present work, I seek to explore the mechanisms underlying modulation of hypoglossal pre\u2010inspiratory discharge by hypercapnia, hypoxia and static and dynamic lung stretch placed upon hypoglossal pre\u2010inspiratory activity, the mechanisms underlying the generation of hypoglossal pre\u2010inspiratory activity, and the extent of microanatomical and functional overlap between propriobulbar interneuronal microcircuits generating hypoglossal pre\u2010inspiratory activity and propriobulbar interneuronal microcircuit oscillators generating pre\u2010inspiratory activity inaugurally inducing respiratory rhythmic activity and thus use experimental data from previous work and that developed by other investigators to explore the modulatory role of lung vagal afferents and intra\u2010neuraxial and carotid body chemoreceptors upon hypoglossal pre\u2010inspiratory activity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1113\/ep087329","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T08:45:36Z","timestamp":1592210736000},"page":"1232-1255","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Retracted: Control of hypoglossal pre\u2010inspiratory discharge"],"prefix":"10.1113","volume":"105","author":[{"given":"Michael George Zaki","family":"Ghali","sequence":"first","affiliation":[{"name":"Departments of Neurological Surgery, Internal Medicine, General Surgery, and Neuroscience Karolinska Institutet  Huddinge Stockholm Sweden"},{"name":"Departments of Neurological Surgery, Neurophysiology, Neuroscience University of Oslo  Oslo Norway"},{"name":"Departments of Neurological Surgery and Neurochemistry University of Helsinki  Helsinki Finland"},{"name":"Departments of Neurological Surgery, Internal Medicine, Cardiothoracic Surgery, and Neuroscience University of California Francisco  San Francisco CA USA"},{"name":"Departments of Neurological Surgery and Neuroscience Barrow Neurological Institute  Phoenix AZ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,16]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2008.167502"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.10193.1"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature18944"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.10193.1"},{"key":"e_1_2_13_6_1","first-page":"647","article-title":"Termination areas of corticobulbar and corticospinal fibres in the rat","volume":"25","author":"Antal M.","year":"1984","journal-title":"Journal f\u00fcr Hirnforschung"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2020.02.005"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1006148"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.43587"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00298.2019"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00499.2017"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(75)90093-6"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2020.103410"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.05.032"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1990.sp018171"},{"key":"e_1_2_13_16_1","first-page":"909","article-title":"Die Selbststeurung der Athmung durch den Nervus Vagus","volume":"58","author":"Breuer J.","year":"1868","journal-title":"Akademie der Wissenschaften Wien (II)"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2018.00030"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2008.05.001"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.08.026"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00514.2010"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1991.sp018597"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(92)90137-L"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1979.59.4.1105"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1984.51.4.753"},{"key":"e_1_2_13_25_1","first-page":"L33","article-title":"Respiratory activity in retrotrapezoid nucleus in cat","volume":"258","author":"Connelly C. A.","year":"1990","journal-title":"The American Journal of Physiology"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(80)90042-0"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(81)90111-0"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00196.2016"},{"key":"e_1_2_13_29_1","first-page":"420","article-title":"The time course of action current in the phrenic nerve and diaphragm with normal innervation","volume":"58","author":"Dittler R.","year":"1912","journal-title":"Zentrum Biologie"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903570305"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1982.sp014041"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2006.04981.x"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2007.06.004"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2006.04.020"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.032805"},{"key":"e_1_2_13_36_1","first-page":"2096","article-title":"Point:Counterpoint: The parafacial respiratory group (pFRG)\/pre\u2010B\u00f6tzinger complex (preBotC) is the primary site of respiratory rhythm generation in the mammal. Counterpoint: The preB\u00f6tC is the primary site of respiratory rhythm generation in the mammal","volume":"100","author":"Feldman J. L.","year":"2006","journal-title":"Journal of Applied Physiology"},{"key":"e_1_2_13_37_1","first-page":"803","article-title":"Nouveaux d\u00e9tails sur le n\u0153ud vital","volume":"47","author":"Flourens P.","year":"1858","journal-title":"Compte Rendu des S\u00e9ances de l'Acad\u00e9mie des Sciences"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5595-07.2008"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(97)00095-9"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.2170\/jjphysiol.32.689"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1998.265bu.x"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2005.03.015"},{"key":"e_1_2_13_43_1","doi-asserted-by":"crossref","unstructured":"Ghali M. Fuller D. &Marchenko V.(2014).State\u2010 and vagal\u2010dependent modulation of augmenting pattern of phrenic nerve discharge during eupnea in rats (726.8). The FASEB Journal. Experimental Biology Conference San Diego CA April 1 2014.","DOI":"10.1096\/fasebj.28.1_supplement.726.8"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2015.05.002"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.31083\/j.jin.2019.04.188"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.31083\/j.jin.2019.03.189"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2013.03.010"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2015.4034"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2016.05.009"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00705.2015"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1987.sp016372"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.90452.2008"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.4088\/PCC.16l02057"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1990.63.5.955"},{"key":"e_1_2_13_55_1","first-page":"672","article-title":"Die Selbststeurung der Athmung durch den Nervus Vagus","volume":"57","author":"Hering E.","year":"1868","journal-title":"Akademie der Wissenschaften Wien (II)"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.179739"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(92)90979-J"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.098848"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.023408"},{"key":"e_1_2_13_60_1","volume-title":"Principles of neural science","author":"Kandel E. R.","year":"2000"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.37.1.41"},{"key":"e_1_2_13_62_1","first-page":"875","article-title":"Executed or attempted strangulation by underage persons","volume":"6","author":"Karsowska J.","year":"1956","journal-title":"Neurologia, Neurochirurgia I Psychiatria Polska"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(97)00085-7"},{"key":"e_1_2_13_64_1","unstructured":"Kristensen M. P. Rector D. M. Poe G. P. &Harper R. M.(1994)Reflectance imaging of the hypothalamic paraventricular region demonstrates biphasic cellular activation patterns in freely behaving cats during noise exposure. First World Congress on Stress 117 (abstract)."},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00252.2006"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(99)00058-4"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01285.2009"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2010.06.015"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00031.2012"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00505.2007"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00982.2005"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00934.2006"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02256322"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(00)00204-8"},{"key":"e_1_2_13_75_1","volume-title":"Exp\u00e9riences sur le principe de la vie, notamment sure celui des mouvements du c\u0153ur, et le si\u00e8ge de ce principe; suivies du rapport fait \u00e0 la premi\u00e8re classe de l'institute sur celles relatives aux mouvements du c\u0153ur","author":"Legallois J. C.","year":"1802"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2004.06.008"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)91871-6"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1996.sp021181"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1923.sp002103"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1923.sp002108"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00292.2012"},{"key":"e_1_2_13_82_1","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0011-16.2016"},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00217.2006"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00218.2006"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00472.2007"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)02377-X"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.6.9903001"},{"key":"e_1_2_13_88_1","first-page":"402","article-title":"Inhibitory mechanism of CO2 inhalation on slowly adapting pulmonary stretch receptors in the anesthetized rabbit","volume":"279","author":"Matsumoto S.","year":"1996","journal-title":"The Journal of Pharmacology and Experimental Therapeutics"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.1002\/wsbm.1371"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-62817-2_9"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01324.2009"},{"key":"e_1_2_13_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2020.103401"},{"key":"e_1_2_13_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.23528"},{"key":"e_1_2_13_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(88)91194-8"},{"key":"e_1_2_13_95_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-04-01478.2003"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2012.03.037"},{"key":"e_1_2_13_97_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01175.2005"},{"key":"e_1_2_13_98_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00554.2014"},{"key":"e_1_2_13_99_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00262.2010"},{"key":"e_1_2_13_100_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1973.53.1.159"},{"key":"e_1_2_13_101_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11897-017-0322-3"},{"key":"e_1_2_13_102_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1996.sp021425"},{"key":"e_1_2_13_103_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1997.623bj.x"},{"key":"e_1_2_13_104_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004240000502"},{"key":"e_1_2_13_105_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.100.1.93"},{"key":"e_1_2_13_106_1","first-page":"109","article-title":"How is the respiratory rhythm generated? A model","volume":"1","author":"Richter D. W.","year":"1986","journal-title":"News in Physiological Sciences"},{"key":"e_1_2_13_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(88)90701-9"},{"key":"e_1_2_13_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-63274-6.00001-1"},{"key":"e_1_2_13_109_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.022566"},{"key":"e_1_2_13_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2012.11.004"},{"key":"e_1_2_13_111_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2009.0081"},{"key":"e_1_2_13_112_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1683005"},{"key":"e_1_2_13_113_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2000.83.5.2854"},{"key":"e_1_2_13_114_1","first-page":"167","article-title":"GABAergic neurons in K\u00f6lliker\u2010Fuse nucleus and B\u00f6tzinger complex with axons projecting to phrenic nucleus","volume":"52","author":"Song G.","year":"2000","journal-title":"Sheng Li Xue Bao [Acta Physiologica Sinica]"},{"key":"e_1_2_13_115_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4168-08.2008"},{"key":"e_1_2_13_116_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-73693-8_66"},{"key":"e_1_2_13_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(98)00872-5"},{"key":"e_1_2_13_118_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00322.2007"},{"key":"e_1_2_13_119_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1975.229.5.1410"},{"key":"e_1_2_13_120_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00492.2010"},{"key":"e_1_2_13_121_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00493.2010"},{"key":"e_1_2_13_122_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.me.39.020188.002443"},{"key":"e_1_2_13_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(00)00201-2"},{"key":"e_1_2_13_124_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00591.2016"}],"updated-by":[{"DOI":"10.1113\/ep089093","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T00:00:00Z","timestamp":1602547200000},"record-id":"24520"},{"DOI":"10.1113\/ep089093","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T00:00:00Z","timestamp":1602547200000}}],"container-title":["Experimental Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2FEP087329","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/EP087329","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1113\/EP087329","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/EP087329","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T12:53:20Z","timestamp":1693227200000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/EP087329"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,16]]},"references-count":123,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1113\/EP087329"],"URL":"https:\/\/doi.org\/10.1113\/ep087329","archive":["Portico"],"relation":{},"ISSN":["0958-0670","1469-445X"],"issn-type":[{"value":"0958-0670","type":"print"},{"value":"1469-445X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,16]]},"assertion":[{"value":"2018-08-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}