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It was observed, for the first time, that BMMC transplantation restores expression of nephrin, a component of the glomerular filtration barrier related to podocytes and the glomerular basal membrane.<\/jats:p>\n<\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Stem cell therapy has emerged as a potential treatment for renal diseases owing to the regenerative potential of stem cells. However, a better understanding of the morphological and functional changes of damaged renal cells in the presence of transplanted stem cells is needed. The aim of this study was to investigate cell\u2013cell communication and adhesion in renal parenchyma, with analysis of fibrosis, to evaluate renal morphology and function after bone marrow mononuclear cell (BMMC) transplantation in two\u2010kidney\u2013one\u2010clip rats. The BMMC therapy significantly decreased blood pressure and renin expression, improved renal morphology and restored the glomerular filtration barrier, with remodelling of podocytes. In addition, there was a reduction in fibrosis, and connexin\u00a040 and nephrin expression were significantly increased after 7 and 15 days of transplantation. Plasma creatinine, urea and total protein levels were restored, and proteinuria was reduced. Furthermore, N\u2010 and E\u2010cadherin expression was increased soon after BMMC therapy. Green fluorescent protein\u2010positive BMMCs were found in the renal cortex 24 and 48\u00a0h after transplantation into the renal subcapsule, and at 7 and 15 days after transplantation, these cells were observed throughout the renal medulla, indicating cellular migration. Therefore, these data suggest that transplanted BMMCs improve cell\u2013cell communication and adhesion between damaged cells, which is accompanied by a recovery of renal morphology and function.<\/jats:p><\/jats:sec>","DOI":"10.1113\/ep087330","type":"journal-article","created":{"date-parts":[[2019,2,21]],"date-time":"2019-02-21T12:08:11Z","timestamp":1550750891000},"page":"740-754","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Bone marrow mononuclear cell transplantation rescues the glomerular filtration barrier and epithelial cellular junctions in a renovascular hypertension model"],"prefix":"10.1113","volume":"104","author":[{"given":"Mariana","family":"Oliveira","sequence":"first","affiliation":[{"name":"Laboratory of Stem Cell Research Histology and Embryology Department Biology Institute State University of Rio de Janeiro, Rio de Janeiro, RJ, 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