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Our previous study shows that the MR redox signalling pathway is associated with angiontensin II (AngII)\u2010induced production of reactive oxygen species (ROS) and endothelial dysfunction in rat mesenteric arteries. In the present study, we hypothesized that this signalling pathway is involved in blood pressure increase, endothelial dysfunction and vascular remodelling in an AngII\u2010induced hypertensive animal model. Sixteen\u2010week\u2010old male Sprague\u2013Dawley rats were subjected to AngII infusion for 2\u00a0weeks with or without treatment with the lysosome fusion inhibitor bafilomycin A1 and ASMase inhibitor amitriptyline. After treatments, aortas were harvested for further study. The results showed that the MR redox signalling pathway was activated as indicated by the increase of MR formation, ASMase activity and ROS production in aorta from AngII\u2010infused rats compared with that from control rats. MR formation and ROS production were significantly inhibited in thoracic aorta from AngII\u2010induced rats treated with bafilomycin A1 and amitriptyline. Both treatments significantly attenuated blood pressure increase, endothelial dysfunction and vascular remodelling including medial hypertrophy, and increased collagen and fibronectin deposition in thoracic aortas from AngII\u2010infused rats. Finally, both treatments significantly prevented the increase of inflammatory factors including monocyte chemotactic protein 1, intercellular adhesion molecule 1 and tumour necrosis factor \u03b1 in thoracic aorta from AngII\u2010infused rats. In conclusion, the present study demonstrates that the MR redox signalling pathway was involved in endothelial dysfunction and medial remodelling in AngII\u2010induced hypertension.<\/jats:p><\/jats:sec>","DOI":"10.1113\/ep087335","type":"journal-article","created":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T08:35:47Z","timestamp":1553848547000},"page":"946-956","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Membrane raft redox signalling contributes to endothelial dysfunction and vascular remodelling of thoracic aorta in angiotensin II\u2010infused rats"],"prefix":"10.1113","volume":"104","author":[{"given":"Jian","family":"Wei","sequence":"first","affiliation":[{"name":"Shanghai Key Laboratory of Hypertension Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Shanghai Institute of Hypertension  Shanghai 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