{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T03:14:02Z","timestamp":1781925242108,"version":"3.54.5"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,9]],"date-time":"2018-12-09T00:00:00Z","timestamp":1544313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP16KK0201"],"award-info":[{"award-number":["JP16KK0201"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["NSERC RGPIN\u20102017\u201003749"],"award-info":[{"award-number":["NSERC RGPIN\u20102017\u201003749"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec>\n                    <jats:title>New Findings<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>\n                            <jats:bold>What is the central question of this study?<\/jats:bold>\n                          <\/jats:p>\n                          <jats:p>Increased respiratory muscle activation is associated with neural and cardiovascular consequences via the respiratory muscle metaboreflex. Does increased sympathetic vasoconstriction originating from the respiratory musculature elicit a reduction in blood flow to an inactive limb in order to maintain blood flow to an active limb?<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            <jats:bold>What is the main finding and its importance?<\/jats:bold>\n                          <\/jats:p>\n                          <jats:p>Arm blood flow was reduced whereas leg blood flow was preserved during mild leg exercise with inspiratory resistance. Blood flow to the active limb is maintained via sympathetic control of blood flow redistribution when the respiratory muscle\u2010induced metaboreflex is activated.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      The purpose of this study was to elucidate the effect of increasing inspiratory muscle work on blood flow to inactive and active limbs. Healthy young men (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a010, 20\u00a0\u00b1\u00a02\u00a0years of age) performed two bilateral dynamic knee\u2010extension and knee\u2010flexion exercise tests at 40% peak oxygen uptake for 10\u00a0min. The trials consisted of spontaneous breathing for 5\u00a0min followed by voluntary hyperventilation either with or without inspiratory resistance for 5\u00a0min (40% of maximal inspiratory mouth pressure, inspiratory duty cycle of 50% and a breathing frequency of 40 breaths\u00a0min\n                      <jats:sup>\u22121<\/jats:sup>\n                      ). Mean arterial blood pressure was acquired using finger photoplethysmography. Blood flow in the brachial artery (inactive limb) and in the femoral artery (active limb) were monitored using Doppler ultrasound. Mean arterial blood pressure during exercise was higher (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05) with inspiratory resistance (121\u00a0\u00b1\u00a07\u00a0mmHg) than without resistance (99\u00a0\u00b1\u00a05\u00a0mmHg). Brachial artery blood flow increased during exercise without inspiratory resistance (120\u00a0\u00b1\u00a031\u00a0ml\u00a0min\n                      <jats:sup>\u22121<\/jats:sup>\n                      ) compared with the resting level, whereas it was attenuated with inspiratory resistance (65\u00a0\u00b1\u00a043\u00a0ml\u00a0min\n                      <jats:sup>\u22121<\/jats:sup>\n                      ). Femoral artery blood flow increased at the onset of exercise and was maintained throughout exercise without inspiratory resistance (2576\u00a0\u00b1\u00a0640\u00a0ml\u00a0min\n                      <jats:sup>\u22121<\/jats:sup>\n                      ) and was unchanged when inspiratory resistance was added (2634\u00a0\u00b1\u00a0659\u00a0ml\u00a0min\n                      <jats:sup>\u22121<\/jats:sup>\n                      ;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&gt;\u00a00.05). These results suggest that sympathetic control of blood redistribution to active limbs is facilitated, in part, by the respiratory muscle\u2010induced metaboreflex.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1113\/ep087380","type":"journal-article","created":{"date-parts":[[2018,11,21]],"date-time":"2018-11-21T15:34:02Z","timestamp":1542814442000},"page":"180-188","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Effect of increased inspiratory muscle work on blood flow to inactive and active limbs during submaximal dynamic exercise"],"prefix":"10.1113","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7245-3496","authenticated-orcid":false,"given":"Keisho","family":"Katayama","sequence":"first","affiliation":[{"name":"Research Center of Health Physical Fitness and Sports Nagoya University Nagoya Japan"},{"name":"Graduate School of Medicine Nagoya University Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanako","family":"Goto","sequence":"additional","affiliation":[{"name":"Graduate School of Medicine Nagoya University Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaori","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Graduate School of Education and Human Development Nagoya University Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuru","family":"Saito","sequence":"additional","affiliation":[{"name":"Applied Physiology Laboratory Toyota Technological Institute Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Ishida","sequence":"additional","affiliation":[{"name":"Research Center of Health Physical Fitness and Sports Nagoya University Nagoya Japan"},{"name":"Graduate School of Medicine Nagoya University Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Graduate School of Medicine Nagoya University Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kana","family":"Shiozawa","sequence":"additional","affiliation":[{"name":"Graduate School of Medicine Nagoya University Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5779-5014","authenticated-orcid":false,"given":"A. 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