{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:21:10Z","timestamp":1787016070244,"version":"build-2736575974"},"reference-count":91,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T00:00:00Z","timestamp":1544400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Wellcome Trust-Health Research Board, Ireland-Science Foundation Ireland Seed","award":["WT108228MA"],"award-info":[{"award-number":["WT108228MA"]}]},{"name":"APC Microbiome Ireland Science Foundation Ireland centre","award":["12\/RC\/2273"],"award-info":[{"award-number":["12\/RC\/2273"]}]},{"name":"Translational Research Access Programme University College Cork, Ireland","award":["2015"],"award-info":[{"award-number":["2015"]}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec>\n                    <jats:title>New Findings<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>\n                            <jats:bold>What is the topic of this review?<\/jats:bold>\n                          <\/jats:p>\n                          <jats:p>Pathophysiological changes linked to irritable bowel syndrome (IBS) include stress and immune activation, changes in gastrointestinal microbial and bile acid profiles and sensitization of extrinsic and intrinsic gut neurons. This review explores the potential role for L\u2010cells in these pathophysiological changes.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            <jats:bold>What advances does it highlight?<\/jats:bold>\n                          <\/jats:p>\n                          <jats:p>L\u2010cells, which secrete glucagon\u2010like peptide\u20101 in response to nutrients, microbial factors, bile acids and short\u2010chain fatty acids, may sense IBS\u2010related changes in the luminal environment. Glucagon\u2010like peptide\u20101 can act as a hormone, a paracrine factor or a neuromodulatory factor and, through its actions on central or peripheral neurons, may play a role in gastrointestinal dysfunction.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>The prevalent and debilitating functional bowel disorder, irritable bowel syndrome (IBS), is characterized by symptoms that include abdominal pain, bloating, diarrhoea and\/or constipation. The heterogeneity of IBS underscores a complex multifactorial pathophysiology, which is not completely understood but involves dysfunction of the bi\u2010directional signalling axis between the brain and the gut. This axis incorporates efferent and afferent branches of the autonomic nervous system, circulating endocrine hormones and immune factors, local paracrine and neurocrine factors and microbial metabolites. L\u2010cells, which are electrically excitable biosensors embedded in the gastrointestinal epithelium, secrete glucagon\u2010like peptide\u20101 (GLP\u20101) in response to nutrients in the small intestine. However, they appear to function in a different manner more distally in the gastrointestinal tract, where they are activated by luminal factors including short\u2010chain fatty acids, bile acids and microbial metabolic products, all of which are altered in IBS patients. Glucagon\u2010like peptide\u20101 can also interact with the hypothalamic\u2013pituitary\u2013adrenal stress axis and the immune system, both of which are activated in IBS. Given that a GLP\u20101 mimetic has been found to alleviate acute pain symptoms in IBS patients, GLP\u20101 might be important in the manifestation of IBS symptoms. This review assesses the current knowledge about the role of GLP\u20101 in IBS pathophysiology and its potential role as a signal transducer in the microbiome\u2013gut\u2013brain signalling axis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1113\/ep087443","type":"journal-article","created":{"date-parts":[[2018,11,16]],"date-time":"2018-11-16T10:19:41Z","timestamp":1542363581000},"page":"3-10","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Endocrine regulation of gut function \u2013 a role for glucagon\u2010like peptide\u20101 in the pathophysiology of irritable bowel syndrome"],"prefix":"10.1113","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7031-4879","authenticated-orcid":false,"given":"Dervla","family":"O'Malley","sequence":"first","affiliation":[{"name":"Department of Physiology University College Cork  Cork 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