{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:10:09Z","timestamp":1747188609754,"version":"3.40.5"},"reference-count":58,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,2,10]],"date-time":"2019-02-10T00:00:00Z","timestamp":1549756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec><jats:title>New Findings<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p><jats:bold>What is the central question of this study?<\/jats:bold><\/jats:p>\n<jats:p>Does oestrous cycle synchronization influence myoelectrical activity of porcine myometrium?<\/jats:p>\n<\/jats:list-item>\n<jats:list-item><jats:p><jats:bold>What is the main finding and its importance?<\/jats:bold><\/jats:p>\n<jats:p>Exogenous hormones used to synchronize oestrus in pigs altered myoelectrical activity, which was effectively modelled. Higher\u2010order multivariate statistic modelling provided evidence of similar activity in both types of oestrus, but a larger order of EMG signals during induced oestrus. Higher\u2010order statistical analysis of the probabilistic model suggests the beginning of the early follicular phase and the mid\u2010luteal phase to be most important in evaluation of the natural patterns of myoelectrical activity. Higher\u2010order multivariate cumulants are more informative than classical statistics in characterization of myoelectrical activity changes in porcine myometrium.<\/jats:p>\n<\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>In pig production units, control of the oestrous cycle and synchronization of ovulation have become routine herd management procedures. During the oestrous cycle, in both induced and spontaneous conditions, the ovaries and the uterus undergo hormone\u2010dominated physiological changes, which are consistent with the hypothesis that there is a functional role of uterine contractions in promoting fertilization. We have used electromyography to determine whether the use of exogenous hormones, such as equine chorionic gonadotrophin and human chorionic gonadotrophin, which have the potential to control the timing of ovulation in female pigs, changes the multivariate relationships between parameters of electrical bursts and modulates the patterns of myoelectrical activity. We used the mathematical approach of higher\u2010order multivariate cumulants in complex modelling of the myometrial electrical activity. The experiment was conducted on 12 mature Polish Landrace sows, and uterine activity was recorded during both spontaneous and induced oestrous cycles. The burst parameters were determined using six features in the time domain and, after Fast Fourier transformation, in the frequency domain. Evaluation of myoelectrical activity patterns was conducted based on classical univariate statistical methods and multivariate probabilistic modelling. The classical statistical approach indicated weaker myoelectrical activity after hormonal stimulation, whereas the higher\u2010order multivariate statistical model showed evidence of similar status of activity and a larger order of signals during induced oestrus. Routine oestrous cycle synchronization affects the multivariate probabilistic model of myometrial electrical activity.<\/jats:p><\/jats:sec>","DOI":"10.1113\/ep087451","type":"journal-article","created":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T21:50:25Z","timestamp":1546984225000},"page":"322-333","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Computational multivariate modelling of electrical activity of the porcine uterus during spontaneous and hormone\u2010induced oestrus"],"prefix":"10.1113","volume":"104","author":[{"given":"Malgorzata","family":"Domino","sequence":"first","affiliation":[{"name":"Department of Large Animal Diseases with Clinic Faculty of Veterinary Medicine Warsaw University of Life Sciences \u2013 Szkola Glowna Gospodarstwa Wiejskiego  Nowoursynowska 100, 02\u2010797 Warsaw Poland"},{"name":"Veterinary Research Centre and Center for Biomedical Research, Faculty of Veterinary Medicine WULS \u2013 SGGW  Nowoursynowska 100, 02\u2010797 Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7386-5441","authenticated-orcid":false,"given":"Krzysztof","family":"Domino","sequence":"additional","affiliation":[{"name":"Institute of Theoretical and Applied Informatics Polish Academy of Sciences  Ba\u0142tycka 5, 44\u2010100 Gliwice Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bartosz","family":"Pawlinski","sequence":"additional","affiliation":[{"name":"Department of Large Animal Diseases with Clinic Faculty of Veterinary Medicine Warsaw University of Life Sciences \u2013 Szkola Glowna Gospodarstwa Wiejskiego  Nowoursynowska 100, 02\u2010797 Warsaw Poland"},{"name":"Veterinary Research Centre and Center for Biomedical Research, Faculty of Veterinary Medicine WULS \u2013 SGGW  Nowoursynowska 100, 02\u2010797 Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Sady","sequence":"additional","affiliation":[{"name":"Department of Large Animal Diseases with Clinic Faculty of Veterinary Medicine Warsaw University of Life Sciences \u2013 Szkola Glowna Gospodarstwa Wiejskiego  Nowoursynowska 100, 02\u2010797 Warsaw Poland"},{"name":"Veterinary Research Centre and Center for Biomedical Research, Faculty of Veterinary Medicine WULS \u2013 SGGW  Nowoursynowska 100, 02\u2010797 Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Gajewska","sequence":"additional","affiliation":[{"name":"Veterinary Research Centre and Center for Biomedical Research, Faculty of Veterinary Medicine WULS \u2013 SGGW  Nowoursynowska 100, 02\u2010797 Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8779-5050","authenticated-orcid":false,"given":"Zdzislaw","family":"Gajewski","sequence":"additional","affiliation":[{"name":"Department of Large Animal Diseases with Clinic Faculty of Veterinary Medicine Warsaw University of Life Sciences \u2013 Szkola Glowna Gospodarstwa Wiejskiego  Nowoursynowska 100, 02\u2010797 Warsaw Poland"},{"name":"Veterinary Research Centre and Center for Biomedical Research, Faculty of Veterinary Medicine WULS \u2013 SGGW  Nowoursynowska 100, 02\u2010797 Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,2,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eswa.2011.06.043"},{"key":"e_1_2_7_3_1","first-page":"187","article-title":"Studies on fixed\u2010time ovulation induction in the pig","volume":"66","author":"Brussow K. 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