{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:14:04Z","timestamp":1740136444045,"version":"3.37.3"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T00:00:00Z","timestamp":1553040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007744","name":"Association pour le D\u00e9veloppement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007744","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec><jats:title>New Findings<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p><jats:bold>What is the central question of this study?<\/jats:bold><\/jats:p>\n<jats:p>Moving to supine induces upper airway modifications and a fluid shift to the neck, which represent inspiratory load that predisposes to upper airway collapse.\u00a0Is there cortical participation in the response to the load induced by transition to a supine posture\u00a0in awake healthy subjects?<\/jats:p>\n<\/jats:list-item>\n<jats:list-item><jats:p><jats:bold>What is the main finding and its importance?<\/jats:bold><\/jats:p>\n<jats:p>Moving to supine induces transient cortical activation in awake healthy subjects, with greater fluid shift, supporting possible cortical participation in the response to upper airway load induced by transition to a supine posture. Our findings open new perspectives in the understanding of the pathogenesis of obstructive sleep apnoea.<\/jats:p>\n<\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Moving from sitting upright to lying supine causes anatomical modifications and a fluid shift to the neck, which represent inspiratory loads that predispose to upper airway collapse. The pre\u2010inspiratory potential (PIP) corresponds to the cortical activity observed during inspiratory load. In the sitting position during wakefulness, some obstructive sleep apnoea patients exhibit PIP, probably in relationship to upper airway abnormalities. The aim of this study was to investigate whether moving to the supine position induces respiratory\u2010related cortical activation (PIP) in awake healthy subjects. The ECG was analysed to detect PIP, and EMG activity of the genioglossus muscle and ventilation were measured in the sitting position, immediately after moving to the supine position, and during application of leg positive pressure in the supine position to promote fluid shift, which was measured by bioelectrical impedance. Twenty\u2010four subjects were included. From sitting to lying, PIP prevalence increased from 1\/24 to 11\/24 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.002), and ventilation decreased with no change in genioglossus activity. The fluid shift from sitting to supine was higher in the subjects exhibiting PIP while supine compared with the subjects without PIP [median (25th; 75th centiles) 440\u00a0(430; 520) <jats:italic>versus<\/jats:italic> 320\u00a0(275; 385)\u00a0ml, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.018], without any other differences. From before to during leg positive pressure, PIP disappeared (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.006). These results indicate that moving from sitting to lying induces transient respiratory\u2010related cortical activity in awake healthy subjects with greater fluid shift, supporting possible cortical participation in the response to upper airway loading induced by moving from sitting upright to lying supine. This study offers new perspectives in the understanding of obstructive sleep apnoea pathogenesis.<\/jats:p><\/jats:sec>","DOI":"10.1113\/ep087468","type":"journal-article","created":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T05:45:22Z","timestamp":1551419122000},"page":"887-895","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Postural respiratory\u2010related cortical activation and rostral fluid shift in awake healthy humans"],"prefix":"10.1113","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6429-666X","authenticated-orcid":false,"given":"Claire","family":"Launois","sequence":"first","affiliation":[{"name":"Sorbonne Universit\u00e9 INSERM UMRS 1158 Neurophysiologie Respiratoire Exp\u00e9rimentale et Clinique  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Perger","sequence":"additional","affiliation":[{"name":"AP\u2010HP Groupe Hospitalier Piti\u00e9\u2010Salp\u00eatri\u00e8re Charles Foix Service de Pathologies du Sommeil D\u00e9partement R3S  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5444-9223","authenticated-orcid":false,"given":"Val\u00e9rie","family":"Attali","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9 INSERM UMRS 1158 Neurophysiologie Respiratoire Exp\u00e9rimentale et Clinique  Paris France"},{"name":"AP\u2010HP Groupe Hospitalier Piti\u00e9\u2010Salp\u00eatri\u00e8re Charles Foix Service de Pathologies du Sommeil D\u00e9partement R3S  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u2010C\u00e9cile","family":"Nierat","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9 INSERM UMRS 1158 Neurophysiologie Respiratoire Exp\u00e9rimentale et Clinique  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathieu","family":"Raux","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9 INSERM UMRS 1158 Neurophysiologie Respiratoire Exp\u00e9rimentale et Clinique  Paris France"},{"name":"AP\u2010HP Groupe Hospitalier Piti\u00e9\u2010Salp\u00eatri\u00e8re Charles Foix D\u00e9partement d'Anesth\u00e9sie R\u00e9animation  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Arnulf","sequence":"additional","affiliation":[{"name":"AP\u2010HP Groupe Hospitalier Piti\u00e9\u2010Salp\u00eatri\u00e8re Charles Foix Service de Pathologies du Sommeil D\u00e9partement R3S  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Similowski","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9 INSERM UMRS 1158 Neurophysiologie Respiratoire Exp\u00e9rimentale et Clinique  Paris France"},{"name":"AP\u2010HP Groupe Hospitalier Piti\u00e9\u2010Salp\u00eatri\u00e8re Charles Foix Service de Pneumologie M\u00e9decine Intensive et R\u00e9animation D\u00e9partement R3S  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Redolfi","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9 INSERM UMRS 1158 Neurophysiologie Respiratoire Exp\u00e9rimentale et Clinique  Paris France"},{"name":"AP\u2010HP Groupe Hospitalier Piti\u00e9\u2010Salp\u00eatri\u00e8re Charles Foix Service de Pathologies du Sommeil D\u00e9partement R3S  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1152\/jappl.1982.53.5.1158","article-title":"Supraglottic airway resistance in normal subjects and patients with occlusive sleep apnea","volume":"53","author":"Anch A. 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