{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:34:57Z","timestamp":1762079697157,"version":"3.40.5"},"reference-count":57,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T00:00:00Z","timestamp":1559433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/06077\u20105"],"award-info":[{"award-number":["2013\/06077\u20105"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec><jats:title>New Findings<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p><jats:bold>What is the central question of this study?<\/jats:bold><\/jats:p>\n<jats:p>Chronic intermittent hypoxia (CIH) causes increased arterial pressure (AP), sympathetic overactivity and changes in expiratory modulation of sympathetic activity. However, changes in the short\u2010term sleep\u2013wake cycle pattern after CIH and their potential impact on cardiorespiratory parameters have not been reported previously.<\/jats:p>\n<\/jats:list-item>\n<jats:list-item><jats:p><jats:bold>What is the main finding and its importance?<\/jats:bold><\/jats:p>\n<jats:p>Exposure to CIH for 10 days elevates AP in wakefulness and sleep but does not cause major changes in short\u2010term sleep\u2013wake cycle pattern. A higher incidence of muscular expiratory activity was observed in rats exposed to CIH only during wakefulness, indicating that active expiration is not required for the increase in AP in rats submitted to CIH.<\/jats:p>\n<\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Chronic intermittent hypoxia (CIH) increases arterial pressure (AP) and changes sympathetic\u2013respiratory coupling. However, the alterations in the sleep\u2013wake cycle after CIH and their potential impact on cardiorespiratory parameters remain unknown. Here, we evaluated whether CIH\u2010exposed rats present changes in their short\u2010term sleep\u2013wake cycle pattern and in cardiorespiratory parameters. Male Wistar rats (\u223c250\u00a0g) were divided into CIH and control groups. The CIH rats were exposed to 8\u00a0h\u00a0day<jats:sup>\u22121<\/jats:sup> of cycles of normoxia (fraction of inspired O<jats:sub>2<\/jats:sub>\u00a0=\u00a00.208, 5\u00a0min) followed by hypoxia (fraction of inspired O<jats:sub>2<\/jats:sub>\u00a0=\u00a00.06, 30\u201340 s) for 10 days. One day after CIH, electrocorticographic activity, cervical EMG, AP and heart rate were recorded for 3\u00a0h. Plethysmographic recordings were collected for 2\u00a0h. A subgroup of control and CIH rats also had the diaphragm and oblique abdominal muscle activities recorded. Chronic intermittent hypoxia did not alter the time for sleep onset, total time awake, durations of rapid eye movement (REM) and non\u2010REM (NREM) sleep and number of REM episodes in the 3\u00a0h recordings. However, a significant increase in the duration of REM episodes was observed. The AP and heart rate were increased in all phases of the cycle in rats exposed to CIH. Respiratory frequency and ventilation were similar between groups in all phases, but tidal volume was increased during NREM and REM sleep in rats exposed to CIH. An increase in the incidence of active expiration during wakefulness was observed in rats exposed to CIH. The data show that CIH\u2010related hypertension is not caused by changes in the sleep\u2013wake cycle and suggest that active expiration is not required for the increase in AP in freely moving rats exposed to CIH.<\/jats:p><\/jats:sec>","DOI":"10.1113\/ep087784","type":"journal-article","created":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T13:02:25Z","timestamp":1558098145000},"page":"1408-1419","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Cardiovascular and respiratory profiles during the sleep\u2013wake cycle of rats previously submitted to chronic intermittent hypoxia"],"prefix":"10.1113","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1835-040X","authenticated-orcid":false,"given":"Darlan S.","family":"Bazilio","sequence":"first","affiliation":[{"name":"Department of Physiology School of Medicine of Ribeir\u00e3o Preto, University of S\u00e3o Paulo  Ribeir\u00e3o Preto SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leni G. 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