{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T23:39:39Z","timestamp":1789947579354,"version":"4.0.1"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T00:00:00Z","timestamp":1574899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002830","name":"Centre National d\u2019Etudes Spatiales","doi-asserted-by":"publisher","award":["48\/846"],"award-info":[{"award-number":["48\/846"]}],"id":[{"id":"10.13039\/501100002830","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec><jats:title>New Findings<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p><jats:bold>What is the central question of this study?<\/jats:bold><\/jats:p>\n<jats:p>A heterogeneous cerebral blood flow (CBF) response in the cerebral arteries has been demonstrated in several physiological conditions, and it might be attributable to different physiological properties. However, the whole cerebral haemodynamic response to weightlessness remains unknown.<\/jats:p>\n<\/jats:list-item>\n<jats:list-item><jats:p><jats:bold>What is the main finding and its importance?<\/jats:bold><\/jats:p>\n<jats:p>Long\u2010term head\u2010down bed rest caused a heterogeneous CBF response between the anterior and posterior cerebral arteries and between the cerebral arteries and veins. Especially, in contrast to the anterior cerebral circulation, the posterior arterial and venous CBFs were well maintained throughout weightlessness.<\/jats:p>\n<\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>In this study, we investigated the whole cerebral haemodynamic response to long\u2010term head\u2010down bed rest (HDBR). We hypothesized that long\u2010term exposure to weightlessness influences cerebral blood flow (CBF) or CBF distribution among cerebral arteries and veins because of the different physiological roles of each cerebral vessel. To test this hypothesis, 10 male volunteers were exposed to \u22126\u00a0deg HDBR for 60\u00a0days. Blood flows in the internal carotid artery, external carotid artery and vertebral artery or internal jugular vein and vertebral vein were measured using ultrasonography before and on days\u00a030 and 57 of the HDBR. The internal carotid artery blood flow was reduced on day\u00a030 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.019) and had returned to the baseline level by day\u00a057. In contrast, the vertebral artery blood flow remained unaltered throughout the HDBR (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.626). The internal jugular vein blood flow was reduced on day\u00a030 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.009), whereas the vertebral vein blood flow remained unaltered (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.397). These findings suggest that long\u2010term HDBR causes a heterogeneous CBF response between the anterior and posterior cerebral circulation in the both arteries and veins. The posterior arterial and venous CBFs were well maintained throughout HDBR, and these CBF responses to HDBR were different from the anterior cerebral circulation.<\/jats:p><\/jats:sec>","DOI":"10.1113\/ep088057","type":"journal-article","created":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T09:33:52Z","timestamp":1573032832000},"page":"44-52","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Arterial and venous cerebral blood flow responses to long\u2010term head\u2010down bed rest in male volunteers"],"prefix":"10.1113","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5297-6468","authenticated-orcid":false,"given":"Shigehiko","family":"Ogoh","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Toyo University  Kawagoe\u2010Shi Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Sato","sequence":"additional","affiliation":[{"name":"Tokyo Gakugei University  Koganei Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"de Abreu","sequence":"additional","affiliation":[{"name":"Normandie Universit\u00e9, Unicaen; 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