{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T09:23:35Z","timestamp":1785835415099,"version":"3.56.0"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,10,26]],"date-time":"2019-10-26T00:00:00Z","timestamp":1572048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000245","name":"Michael Smith Foundation for Health Research","doi-asserted-by":"publisher","award":["16806"],"award-info":[{"award-number":["16806"]}],"id":[{"id":"10.13039\/501100000245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000196","name":"Canada Foundation for Innovation","doi-asserted-by":"publisher","award":["32158"],"award-info":[{"award-number":["32158"]}],"id":[{"id":"10.13039\/501100000196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN\u20102014\u201005643"],"award-info":[{"award-number":["RGPIN\u20102014\u201005643"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2020,2]]},"abstract":"New Findings<\/jats:title>\nWhat is the central question of this study?<\/jats:bold><\/jats:p>\nAcetazolamide and methazolamide both reduce hypoxic pulmonary vasoconstriction equally, but methazolamide does not impair skeletal muscle function. The effect of methazolamide on respiratory control in humans is not yet known.<\/jats:p>\n<\/jats:list-item>\nWhat is the main finding and its importance?<\/jats:bold><\/jats:p>\nSimilar to acetazolamide after chronic oral administration, methazolamide causes a metabolic acidosis and shifts the ventilatory CO2<\/jats:sub> response curve leftwards without reducing O2<\/jats:sub> sensitivity. The change in ventilation over the change in log provides a more accurate measure of hypoxic sensitivity than the change in ventilation over the change in arterial oxyhaemoglobin saturation.<\/jats:p>\n<\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>Abstract<\/jats:title>Acetazolamide is used to prevent\/treat acute mountain sickness and both central and obstructive sleep apnoea. Methazolamide, like acetazolamide, reduces hypoxic pulmonary vasoconstriction, but has fewer side\u2010effects, including less impairment of skeletal muscle function. Given that the effects of methazolamide on respiratory control in humans are unknown, we compared the effects of oral methazolamide and acetazolamide on ventilatory control and determined the ventilation\u2013log\u00a0 relationship in humans. In a double\u2010blind, placebo\u2010controlled, randomized cross\u2010over design, we studied the effects of acetazolamide (250\u00a0mg three times daily), methazolamide (100\u00a0mg twice daily) and placebo in 14 young male subjects who were exposed to 7\u00a0min of normoxic hypercapnia and to three levels of eucapnia and hypercapnic hypoxia. With placebo, methazolamide and acetazolamide, the CO2<\/jats:sub> sensitivities were 2.39\u00a0\u00b1\u00a01.29, 3.27\u00a0\u00b1\u00a01.82 and 2.62\u00a0\u00b1\u00a01.79 l\u00a0min\u22121<\/jats:sup>\u00a0mmHg\u22121<\/jats:sup> (n.s.) and estimated apnoeic thresholds 32\u00a0\u00b1\u00a03, 28\u00a0\u00b1\u00a03 and 26\u00a0\u00b1\u00a03\u00a0mmHg, respectively (P<\/jats:italic>\u00a0<\u00a00.001, placebo versus<\/jats:italic> methazolamide and acetazolamide). The relationship between ventilation () and log\u00a0 (using arterialized venous in hypoxia) was linear, and neither agent influenced the relationship between hypoxic sensitivity () and arterial [H+<\/jats:sup>]. Using rather than \u0394\/\u0394 arterial oxyhaemoglobin saturation enables a more accurate estimation of oxygenation and ventilatory control in metabolic acidosis\/alkalosis when right\u2010 or leftward shifts of the oxyhaemoglobin saturation curve occur. Given that acetazolamide and methazolamide have similar effects on ventilatory control, methazolamide might be preferred for indications requiring the use of a carbonic anhydrase inhibitor, avoiding some of the negative side\u2010effects of acetazolamide.<\/jats:p><\/jats:sec>","DOI":"10.1113\/ep088058","type":"journal-article","created":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T08:44:26Z","timestamp":1570610666000},"page":"293-301","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Influence of methazolamide on the human control of breathing: A comparison to acetazolamide"],"prefix":"10.1113","volume":"105","author":[{"given":"Luc J.","family":"Teppema","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0477-6511","authenticated-orcid":false,"given":"Lindsey M.","family":"Boulet","sequence":"additional","affiliation":[{"name":"Centre for Heart, Lung, and Vascular Health School of Health and Exercise Science University of British Columbia Kelowna BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather K.","family":"Hackett","sequence":"additional","affiliation":[{"name":"Centre for Heart, Lung, and Vascular Health School of Health and Exercise Science University of British Columbia Kelowna BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5575-4043","authenticated-orcid":false,"given":"Paolo B.","family":"Dominelli","sequence":"additional","affiliation":[{"name":"Centre for Heart, Lung, and Vascular Health School of Health and Exercise Science University of British Columbia Kelowna BC Canada"},{"name":"Department of Kinesiology University of Waterloo Waterloo ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William S.","family":"Cheyne","sequence":"additional","affiliation":[{"name":"Centre for Heart, Lung, and Vascular Health School of Health and Exercise Science University of British Columbia Kelowna BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio S.","family":"Dominelli","sequence":"additional","affiliation":[{"name":"Southern Medical Program University of British Columbia Kelowna BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik R.","family":"Swenson","sequence":"additional","affiliation":[{"name":"Division of Pulmonary & Critical Care Medicine VA Puget Sound Health Care System University of Washington Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4110-9574","authenticated-orcid":false,"given":"Glen E.","family":"Foster","sequence":"additional","affiliation":[{"name":"Centre for Heart, Lung, and Vascular Health School of Health and Exercise Science University of British Columbia Kelowna BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,26]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"1086","article-title":"Acetazolamide use in severe chronic obstructive pulmonary disease. 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